DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and PTP1

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_010051.1	Gene:	PTP1 / 851368	SGDID:	S000002389	Length:	335	Species:	Saccharomyces cerevisiae

Alignment Length:	332	Identity:	103/332 - (31%)
Similarity:	159/332 - (47%)	Gaps:	80/332 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1258 AEHYRLMSADSD----FRFSEEFEELKHVGRDQPCTFADL-----------PCNRPKNRFTNILP 1307
            |..:.:...|:|    |:|.:..|:    ||.:..|...:           |.|..:||:.||:|
Yeast     3 AAPWYIRQRDTDLLGKFKFIQNQED----GRLREATNGTVNSRWSLGVSIEPRNDARNRYVNIMP 63

  Fly  1308 YDHSRFKLQPVDDDEGSDYINANY----VPGHN-SPREFIVTQGPLHSTRDDFWRMCWES---NS 1364
            |:.:|..|:.:   .|:|||||:|    |||.: .|..:|.||||...|.|.||:||:.:   ::
Yeast    64 YERNRVHLKTL---SGNDYINASYVKVNVPGQSIEPGYYIATQGPTRKTWDQFWQMCYHNCPLDN 125

  Fly  1365 RAIVMLTRCFEKGREKCDQYWP----NDTVPV---------------FYGDIKVQILNDSHYAD- 1409
            ..|||:|...|..||||.||||    :|||.:               |..|:|::.:|.....|
Yeast   126 IVIVMVTPLVEYNREKCYQYWPRGGVDDTVRIASKWESPGGANDMTQFPSDLKIEFVNVHKVKDY 190

  Fly  1410 WVMTEFMLCRG----SEQRILRHFHFTTWPDFGVPNPPQTLVRFVR--AFRDRIGAEQRPIVVHC 1468
            :.:|:..|...    ...:.:.||:|..|.|.   |.|:.:|..:.  |....:.:...||:|||
Yeast   191 YTVTDIKLTPTDPLVGPVKTVHHFYFDLWKDM---NKPEEVVPIMELCAHSHSLNSRGNPIIVHC 252

  Fly  1469 SAGVGRSGTFITLDRILQQINTSDYVDIF-------------------GIVYAMRKERVWMVQTE 1514
            ||||||:||||.||.::.  :|.|:.:|.                   .||..:|.:|:.||||:
Yeast   253 SAGVGRTGTFIALDHLMH--DTLDFKNITERSRHSDRATEEYTRDLIEQIVLQLRSQRMKMVQTK 315

  Fly  1515 QQYICIH 1521
            .|::.|:
Yeast   316 DQFLFIY 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	99/314 (32%)
		PTPc	1298..1525	CDD:238006	92/277 (33%)
PTP1	NP_010051.1	COG5599	1..335	CDD:227886	103/332 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I1104
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940