DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and PTPN5

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_016873923.1	Gene:	PTPN5 / 84867	HGNCID:	9657	Length:	719	Species:	Homo sapiens

Alignment Length:	414	Identity:	101/414 - (24%)
Similarity:	149/414 - (35%)	Gaps:	130/414 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1055 PPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSY 1119
            ||.|.|.:.|                                  ||..::.|  ..||:    :|
Human   169 PPEPPTPLPP----------------------------------EDRRQSVS--RQPSF----TY 193

  Fly  1120 SVWLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTA 1184
            |.|:            ...:||..:..:......:..|...:|            ..||..:.|.
Human   194 SEWM------------EEKIEDDFLDLDPVPETPVFDCVMDIK------------PEADPTSLTV 234

  Fly  1185 YSFPIQTDQ-DNTSLIVAITVPLTIILVLLVTLLFYKRRRNNCRK-------TTKDSRANDNMSL 1241
            .|..:|..: .|.||.:.:..|                   .|.:       :.::..|.:.:..
Human   235 KSMGLQERRGSNVSLTLDMCTP-------------------GCNEEGFGYLMSPREESAREYLLS 280

  Fly  1242 PDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFA-----DLPCNRPKNR 1301
            ...|::          ||.....:.| .|....||.|:       |..|.     |:|....|||
Human   281 ASRVLQ----------AEELHEKALD-PFLLQAEFFEI-------PMNFVDPKEYDIPGLVRKNR 327

  Fly  1302 FTNILPYDHSRFKL-QPVDDDEGSDYINANYVPGHNSPRE-FIVTQGPLHSTRDDFWRMCWESNS 1364
            :..|||..|||..| .|..||..|.||||||:.|:....: :|.||||:.||..|||||.|:.::
Human   328 YKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHT 392

  Fly  1365 RAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFML-CRGSEQRILR- 1427
            ..|||:|. .|:..|||.:|||.:.|.  |..:::.:....|..|:.:....| ||..|.|:|.
Human   393 PIIVMITN-IEEMNEKCTEYWPEEQVA--YDGVEITVQKVIHTEDYRLRLISLKCRDWEDRLLHC 454

  Fly  1428 HFHFTT---------WPDFGVPNP 1442
            |.|...         .|:..||.|
Human   455 HQHLLPAAAAGGCGGHPEDHVPAP 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	68/189 (36%)
		PTPc	1298..1525	CDD:238006	61/158 (39%)
PTPN5	XP_016873923.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910