DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and Tnxb

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_006525248.1	Gene:	Tnxb / 81877	MGIID:	1932137	Length:	4361	Species:	Mus musculus

Alignment Length:	1314	Identity:	267/1314 - (20%)
Similarity:	477/1314 - (36%)	Gaps:	318/1314 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LAAFTLKDVRCADLAISIPNNPGLDDGASYRLDYSPPFGYPEPNTTIASREIGDEIQFSRALPGT 96
            |...|:.|.....|::|.....|..|  .:.:.|....|.|:. ..:...|  |::..|...|..
Mouse  2524 LEELTVTDATPDSLSLSWTVPEGQFD--QFVIQYKNGDGQPKV-VRVPGHE--DQVTISGLEPDH 2583

  Fly    97 KYNFWLYYTNFTHHDWLTWTVTITTA-PDPPS------------------------NLSVQVRSG 136
            ||...||.............|.:|.| .:|||                        .|:|...|.
Mouse  2584 KYKMNLYGIYSGQRVGPVSAVGVTAAEEEPPSPTEPRTEAPEPTEAPEPTEEPRLGELTVTGSSP 2648

  Fly   137 KNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIYD 201
            .:..:.|:.| :|.:.:|.::.    :.|....:..:|.....:..|::|.||..|::..|.:::
Mouse  2649 DSLSLSWTIP-KGDFDSFTVQY----KDSDGRPQVIRVRGQEREVIVRDLDPGRKYKMNLYGLHE 2708

  Fly   202 GK-------------ESVAYTSRNF-TTKPNTP------GKFIVWFRNETTLLVLWQPPYPAGIY 246
            |:             |..|.|::.. ||.|..|      |:..|......:|.:.|..|...  :
Mouse  2709 GRRVGPVSTIGVTAPEEEALTTQAVPTTTPEPPPKKPHLGELTVTDATPDSLSLSWTVPEEQ--F 2771

  Fly   247 THYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQ----------------TM 295
            ..:.:..:..|....|:.|     |....|....||.|...|.:::.                |.
Mouse  2772 DQFVIQYKNGDGQPKVVRV-----PGHEDQVTISGLEPDHKYKMNLYGIYSGQRVGPVSVVGVTA 2831

  Fly   296 SEDEISLPTTAQYRTVP-----------LRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVS 349
            :|:|...|..:.....|           |..|.||..    :.:|..:.|..|||  :||.:.|.
Mouse  2832 AEEEPPSPEPSTEAPEPTEAPEPTEEPLLGELTVTGS----SPDSLILSWTIPKG--DFDSFTVQ 2890

  Fly   350 VATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNV---------------IVKTVSGKVTSWPATG 399
            ...:..:..|.|..........||: :||:.:.:               .|.....:.|:..|..
Mouse  2891 YKDSDGRPQVMRVGGQEREVIVRDL-DPGRKYKMNLYGLHEGRRVGPVSTVGVTEEEATTTQAEP 2954

  Fly   400 DVTLRPLPVR---NLRSINDDKTNTMIITWEADPASTQDEYRIVYHELETFNGD----TSTLTTD 457
            .||..|.|.:   .:.::.|...:::.::|.. |.:..|::.|.|.     |||    ...:...
Mouse  2955 IVTTEPPPKKPHLGVLTVTDATPDSLSLSWTV-PEAHFDQFVIQYK-----NGDGQPKVVRVPGH 3013

  Fly   458 RTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVV----------TRPSSPIIEDLKSIRMG-- 510
            ..:.|:..|.|...|.:::..:.........|...|          |.||:...|..:...:|
Mouse  3014 EDQVTISGLEPDHKYKMNLYGIYSGQRVGPVSAVGVTAAEEEPPSPTEPSTEAPESTEEPLLGEL 3078

  Fly   511 ---------LNISW---KSDVNSKQEQYEVLYSRNGTSDLRTQKTK----ESRLVIKNLQPGAGY 559
                     |::||   :.:.:|...||:       .||.|.|..:    |..:::::|.||..|
Mouse  3079 TVTGSSPDSLSLSWTVPQGEFDSFTVQYK-------DSDGRPQVMRVGGQEREVIVRDLDPGRKY 3136

  Fly   560 ELKVFAVSHDLR---------SEPHAYFQAVYPN-----PPR-----NMTIETVRSNSVLVHWSP 605
            ::.::.:....|         :|..|....|.|.     ||:     .:|:....|:|:.:.|:.
Mouse  3137 KMNLYGLHEGRRVGPVSTVGMTEKEALTTQVVPTTTPEPPPKKPHLGELTVTDATSDSLSLSWTV 3201

  Fly   606 PESGEFTEYSIRYRT-DSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVES-----PVP 664
            || |:|.::.|:|:. |.:.:.||:|. ...:..|:.:....||.:.:    :|:.|     ||.
Mouse  3202 PE-GQFEQFVIQYKNGDGQPKVVRVPG-HEDQVTISGLEPDHKYKMNL----YGIHSGQRFGPVS 3260

  Fly   665 QEVNTTV---PPNPVSNIIQLVDSR----------------NITLEWPKPEGRVESYILKWWPSD 710
            ....||.   ||:|....|:..:..                :::|.|..|:|..:|:.:::  .|
Mouse  3261 TVGVTTAVEEPPSPTEPSIEAPEPTEEPLLGELTVTGSSPDSLSLSWTVPQGDFDSFTVQY--KD 3323

  Fly   711 NPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDI----------QTTSYGILSGITS--- 762
            :.||.|...|...:.       .|::.:|.||.:||.::          ..::.|:.:.:|:
Mouse  3324 SDGRPQVMRVGGQER-------EVIVRDLDPGRKYKMNLYGLHEGRRVGPVSTVGVTASLTTEPP 3381

  Fly   763 LYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDR 827
            :.||...|...:|.         ..|:.||:|   .:...||.:.....|.:.:.:....:....
Mouse  3382 IEPRLGELAAVEVT---------SSTVHLSWT---VAQGPFDSFLVQYKDTQGQPQMVPVSGDLG 3434

  Fly   828 KVTFTGLVPGRLYNITVWTVSGGVASLPIQRQ------DRLYPEPITQLHATNITDTEISLRWDL 886
            :||.:||.|.|.|...::.:..|....|:..:      .:|.|. :.:|..|:.|...:.|.|.:
Mouse  3435 EVTVSGLEPARKYKFLLFGLKDGKRHGPVSTEAKTVSDAKLLPR-LGELTVTDTTQNSVGLSWTV 3498

  Fly   887 PKGEYNDFDIAY-----------LTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSV 940
            |:||::.|.:.|           ..||         :.|:|||.|.|:|.|.|.:....|
Mouse  3499 PEGEFDSFLVQYKNRGGQVQVVPAAAD---------QREVTISSLEPNRKYRFLLFGLIG----- 3549

  Fly   941 LRSSSPLSASFTTN--EAVP-GRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNL 1002
            |:...|:|...||.  |..| .|:.....|:.....::..||:    |.|....|.:.|.:
Mouse  3550 LKRLGPVSVEGTTAPVEKTPQPRLGELSVTEETSDSMHLSWSV----AQGPFDSFLVQYKD---- 3606

  Fly  1003 TDAGMQ--DFESEEAFGVIKNLKPGETYVFKIQAKT---------AIGF--------GPEREYRQ 1048
            .|..:|  ...:::....|:.|:||..|.|.:...|         |:|.        .|:    .
Mouse  3607 RDGQLQTVSLAADQREVTIEGLQPGRKYKFLLYGLTGGKRLGPISALGVTASEVDISAPD----H 3667

  Fly  1049 TMPILAP---PRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIV-AEDDAKNASGLE 1109
            |.|..||   ....|:..|..:..|.:..:..|.......|:.:.....::| .:.|....||||
Mouse  3668 TEPPHAPGLGTLAVTEATPDSLRLSWAVARGPFDSFVVQYQDTENETQALLVDGDQDKVLISGLE 3732

  Fly  1110 MPSWLDVQSYSVWL 1123
            ..:     ||..:|
Mouse  3733 PKT-----SYKFFL 3741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	19/117 (16%)
		fn3	220..304	CDD:278470	18/105 (17%)
		fn3	315..391	CDD:278470	18/90 (20%)
		FN3	405..494	CDD:238020	17/105 (16%)
		FN3	511..574	CDD:238020	16/78 (21%)
		FN3	583..671	CDD:238020	25/103 (24%)
		fn3	683..753	CDD:278470	16/95 (17%)
		fn3	787..850	CDD:278470	14/62 (23%)
		fn3	866..935	CDD:278470	21/79 (27%)
		fn3	961..1043	CDD:278470	18/100 (18%)
		PTPc	1272..1525	CDD:214550
		PTPc	1298..1525	CDD:238006
Tnxb	XP_006525248.1	EGF_2	172..200	CDD:285248
		EGF_2	203..231	CDD:285248
		EGF_Tenascin	236..262	CDD:376143
		EGF_Tenascin	267..293	CDD:376143
		EGF_Tenascin	298..325	CDD:376143
		EGF_Tenascin	329..356	CDD:376143
		EGF_Tenascin	360..386	CDD:376143
		EGF_2	389..417	CDD:285248
		EGF_Tenascin	422..448	CDD:376143
		EGF_2	451..479	CDD:285248
		EGF_2	482..510	CDD:285248
		DSL	<498..541	CDD:366627
		EGF_2	541..572	CDD:285248
		EGF_Tenascin	577..604	CDD:376143
		EGF_2	608..634	CDD:285248
		EGF_Tenascin	639..665	CDD:376143
		EGF_Tenascin	706..732	CDD:376143
		fn3	737..818	CDD:365830
		fn3	830..906	CDD:365830
		fn3	1074..1142	CDD:365830
		fn3	1295..1369	CDD:365830
		FN3	1386..1466	CDD:238020
		fn3	1484..1558	CDD:365830
		fn3	1599..1674	CDD:365830
		fn3	1707..1782	CDD:365830
		fn3	1804..1874	CDD:365830
		fn3	1904..1971	CDD:365830
		fn3	2000..2067	CDD:365830
		fn3	2102..2164	CDD:365830
		FN3	2211..2279	CDD:238020
		fn3	2315..2393	CDD:365830
		fn3	2426..2496	CDD:365830
		fn3	2525..2600	CDD:365830	17/79 (22%)
		fn3	2639..2709	CDD:365830	15/74 (20%)
		fn3	2748..2823	CDD:365830	14/81 (17%)
		fn3	2861..2931	CDD:365830	17/76 (22%)
		fn3	2970..3043	CDD:365830	13/78 (17%)
		fn3	3076..3146	CDD:365830	16/76 (21%)
		fn3	3183..3258	CDD:365830	19/80 (24%)
		fn3	3291..3361	CDD:365830	16/78 (21%)
		fn3	3387..3462	CDD:365830	17/86 (20%)
		fn3	3480..3542	CDD:365830	20/70 (29%)
		fn3	3569..3649	CDD:365830	18/87 (21%)
		fn3	3679..3752	CDD:365830	14/68 (21%)
		fn3	3776..3855	CDD:365830
		fn3	3875..3953	CDD:365830
		FN3	3962..4048	CDD:238020
		fn3	4052..4129	CDD:365830
		Fibrinogen_C	4143..4352	CDD:278572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910