Protein Alignment Ptp10D and epha5

DIOPT Version :10

• Sequence 1: NP_996413.2
• Gene: Ptp10D / 32115
• FlyBaseID: FBgn0004370
• Length: 1990
• Species: Drosophila melanogaster
• Sequence 2: XP_001338064.4
• Gene: epha5 / 797595
• -ID: -
• Length: 983
• Species: Danio rerio
• Alignment Length: 756
• Identity: 146/756 - (19%)
• Similarity: 269/756 - (35%)
• Gaps: 189/756 - (25%)

  Fly   873 TNITDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNMTT---------------------RN-EI 915
            :|:.:|.:.|.|..|:......|:.|    |:|...::|                     || .:
Zfish   334 SNVNETSVFLEWTAPEDTGGRKDVRY----NILCSKISTDSGHYEPCGSHVRFLPQRTGLRNTSV 394

  Fly   916 TISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSL 980
            .:.||..|.||||.|...:|...........:|.:.|||:|.|..:..........:.|...|..
Zfish   395 MVVDLLAHTNYTFEVEAMNGVSDLTGPPRQYVSLNVTTNQAAPSPITVVKKGKTTKNSITVSWQE 459

  Fly   981 PSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGP-ER 1044
            | ...||:|.::.|.|...:..|...:  .:|:|...::..|||...|:|:|:|:|:.|:|. .|
Zfish   460 P-DRPNGIILEYEIKYFEKDQETSYTI--IKSKETEVLVDGLKPSSAYIFQIRARTSAGYGGFSR 521

  Fly  1045 EYR-QTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAK----N 1104
            .:. :|.|.||......||....|..:...|.|.....:.  .:|:...|:....:.|.:    :
Zfish   522 RFEFETSPYLAASSEQGQVPIIAVAVTVGIILIALVTGFL--MSGRRCGYSKAKQDPDEEKMHFH 584

  Fly  1105 ASGLEMPSWLDVQSYSVWLPYQAIDPY-YPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYR 1168
            ...::.||   |::|        |||: |...|::|.:|....:.|       |
Zfish   585 NGHIKFPS---VRTY--------IDPHTYEDPNQAVHEFAKEIDVC-------C----------- 620

  Fly  1169 VKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAITVP----LTIILVLLVTLLFYKRRRNNCRKT 1229
            :.:....||.:|.:.....              :.:|    :.:.:..|......|:||:...:.
Zfish   621 ITIERVIGAGEFGEVCSGL--------------LRLPGKREIPVAIKTLKAGYTEKQRRDFLGEA 671

  Fly  1230 T-KDSRANDNMSLPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSE-EFEELKHVGRDQPCTFAD 1292
            : .....:.|:.....||.:::|::|  ..|:....|.|:..:.:: :|..::.||.
Zfish   672 SIMGQFEHPNIIHLKGVITKSKPVMI--ITEYMENGSLDTFLKKNDGQFTVIQLVGM-------- 726

  Fly  1293 LPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPG----------HNSPREFIVTQG- 1346
            |.......|:.:.:.|.|.....:.:       .:|:|.|..          .:.|.....|:|
Zfish   727 LRGIASGMRYLSEMGYVHRDLAARNI-------LVNSNLVCKVSDFGLSRVLEDDPEAAYTTRGG 784

  Fly  1347 --PLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYAD 1409
              |:..|..:           ||     .:.|.....| .|.       ||.:..::::......
Zfish   785 KIPIRWTAPE-----------AI-----AYRKFTSASD-VWS-------YGIVMWEVMSYGERPY 825

  Fly  1410 WVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNP---PQTLVRFVRAF--RDRIGAEQRP----IV 1465
            |.|:...:.:..|:            ::.:|.|   |..|...:...  :||   ..||    ||
Zfish   826 WEMSNQDVIKAVEE------------NYRLPGPMDCPTALYHLMMDCWQKDR---NSRPKFEEIV 875

  Fly  1466 VHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEG 1530
                         ..||::::  |.|   .:.|:|....:....:|:......|:.:.:...||.
Zfish   876 -------------SLLDKLIR--NPS---SLKGLVNPSNRVSNLLVEQGSPEGCVFRSVEEWLEA 922

  Fly  1531 KENIVGPAREMHDNEGYEGQQV----QLDENGDVVATIEGH 1567
            .:  :|...|:....||...||    .|::...|..|:.||
Zfish   923 IK--MGRYTELFMESGYTSLQVVTQMTLEDLRRVGVTLAGH 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:394996
		fn3	220..304	CDD:394996
		FN3	278..>734	CDD:442628
		FN3	583..671	CDD:238020
		fn3	787..850	CDD:394996
		fn3	866..935	CDD:394996	20/83 (24%)
		fn3	959..1043	CDD:394996	21/84 (25%)
		PTP_tm	1083..1187	CDD:465889	19/108 (18%)
		R3-PTPc	1301..1522	CDD:350396	39/242 (16%)
epha5	XP_001338064.4	EphR_LBD_A5	28..200	CDD:198451
		FN3	<323..>551	CDD:442628	56/223 (25%)
		FN3	437..527	CDD:238020	23/92 (25%)
		EphA2_TM	543..618	CDD:464211	17/87 (20%)
		PTKc_EphR_A	616..882	CDD:270651	55/366 (15%)
		SAM_superfamily	913..976	CDD:472832	13/51 (25%)