DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and PTPRZ1

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:NP_002842.2 Gene:PTPRZ1 / 5803 HGNCID:9685 Length:2315 Species:Homo sapiens


Alignment Length:2156 Identity:457/2156 - (21%)
Similarity:725/2156 - (33%) Gaps:743/2156 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 GASYRLDYSPPFGYPEPNTTIASREIGDEIQFSRALPGTKYNFWLYYTNFTHH------DWLTWT 116
            |....||:.......|..:....:...|.......||.:...:::|..:.|..      ||:.:.
Human   186 GTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFK 250

  Fly   117 VTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVNDNTFQH 181
            .|::.:.                          |..|...:||.:.:  |.|........|.|:.
Human   251 DTVSISE--------------------------SQLAVFCEVLTMQQ--SGYVMLMDYLQNNFRE 287

  Fly   182 SVKELTPGATYQVQAYTIYDGKESV-----AYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPY 241
            ...:      :..|.::.|.|||.:     :....|....|          .|.|:|||.|:.|.
Human   288 QQYK------FSRQVFSSYTGKEEIHEAVCSSEPENVQADP----------ENYTSLLVTWERPR 336

  Fly   242 PAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQ----------AAFKGLVPGRAYNISVQTMS 296
            ..     |...||    ..:|||.:.:||.....:          |....|:|..:|.:.:..:.
Human   337 VV-----YDTMIE----KFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAIC 392

  Fly   297 --------EDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISE----------- 342
                    .|::.:........:.|.|       :.|.:.......|..|.|.|           
Human   393 TNGLYGKYSDQLIVDMPTDNPELDLFP-------ELIGTEEIIKEEEEGKDIEEGAIVNPGRDSA 450

  Fly   343 ---FDKYQVSVATTRRQSTV-PRSNE------PVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPA 397
               ..|.:..::||...:.: .:.||      |....:|   :..|...|..:.:.|..||....
Human   451 TNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEF---SGKGDVPNTSLNSTSQPVTKLAT 512

  Fly   398 TGDVTLRPLPVRNL---------RSIND-----------------DKTNTMIITWEADPASTQDE 436
            ..|::|....|..|         .|:||                 :..||:.||      ..::|
Human   513 EKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSIT------EYEEE 571

  Fly   437 YRIVYHELETFNGDT--STLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRP--- 496
            ..:...:|:|...|:  |:..|....|..|::..|..:|         .|:.||..:.|..|   
Human   572 SLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFS---------SENPETITYDVLIPESA 627

  Fly   497 --------SSPIIEDLKSIRMGLNISWKS--------DVNSKQEQYEVLYSRNGTSDLRTQKTK- 544
                    ||...|.||...|..|:.:.|        ||.|.:|.:           |:|..|: 
Human   628 RNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESF-----------LQTNYTEI 681

  Fly   545 ---ESRLVIKNLQPG---------AGYELKVFAVSHDLRSE--PHA------------------- 576
               ||....|:...|         ...|:..::......:|  |||                   
Human   682 RVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYS 746

  Fly   577 ----------------YFQAVYP--------NPPRNMTIETVRSNSVLVHWSPP-ESGEFTEYSI 616
                            |...|:|        |...|.|.....|:|.| |.:|. .|.:.:..||
Human   747 QTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSAL-HATPVFPSVDVSFESI 810

  Fly   617 RYRTD------------SEQQWVRLPSVRSTEADITDMTKGEKYTIQVN---------------- 653
            ....|            |.:.:..|.:|......:|..|:.:|..:..:                
Human   811 LSSYDGAPLLPFSSASFSSELFRHLHTVSQILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQ 875

  Fly   654 -------------TVSFGVESPVPQEV---NTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESY 702
                         |:.||.||.|..:.   :...||:..:    ::.:|:   ..|:|     ||
Human   876 YSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDA----MMHARS---SGPEP-----SY 928

  Fly   703 ILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRT 767
            .|    |||.|......||.:.:.....:|         ||.|:..:.:....|....:||...|
Human   929 AL----SDNEGSQHIFTVSYSSAIPVHDSV---------GVTYQGSLFSGPSHIPIPKSSLITPT 980

  Fly   768 MPLIQSDVVVA-----NGEKED------ERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKL 821
            ..|:|....::     :|...|      :.|.:|.....:|.|.::|.......||    |.:.|
Human   981 ASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISSPVSVAEFTYTTSVFGD----DNKAL 1041

  Fly   822 A-------NDTDRKV-TFTGLV--------PGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQL 870
            :       |:|:.:: :|..:|        |....|:.....|....|:.|.....::|..:...
Human  1042 SKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQETSVSISSTKGMFPGSLAHT 1106

  Fly   871 HATNITDTEISLRWDLPKGEYN---DFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVV 932
             .|.:.|.|||   .:|:..::   ...::..:.|..|...::..:|...||             
Human  1107 -TTKVFDHEIS---QVPENNFSVQPTHTVSQASGDTSLKPVLSANSEPASSD------------- 1154

  Fly   933 RSGTESSVLRSSSPL-----SASFTTN--------------------EAVPG--------RVERF 964
              ...|.:|..|:.|     ||||:|.                    .|||.        :|::.
Human  1155 --PASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLPAVPSDPILVETPKVDKI 1217

  Fly   965 HPT------------------------DVQPSEINFEWSL------------------------- 980
            ..|                        ||.|:......||                         
Human  1218 SSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSESSHQV 1282

  Fly   981 -PSSEANGVIRQFSIAYTNINN----------------------------------LTD------ 1004
             ||..:|..:  |..|...||.                                  ||.      
Human  1283 VPSLYSNDEL--FQTANLEINQAHPPKGRHVFATPVLSIDEPLNTLINKLIHSDEILTSTKSSVT 1345

  Fly  1005 ----AGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPAT----- 1060
                ||:....|:.......::..|..:|    |.||:  .|.|:...|...|..|..||     
Human  1346 GKVFAGIPTVASDTFVSTDHSVPIGNGHV----AITAV--SPHRDGSVTSTKLLFPSKATSELSH 1404

  Fly  1061 ------------------------------------QVVPTEVYRSSSTIQIR---FRKNYFSDQ 1086
                                                :.:....||.|....:.   ..:|...||
Human  1405 SAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKVMNDSDTHENSLMDQ 1469

  Fly  1087 NGQVRMYTIIVAEDD--------------------AKNASGLEM-----PSWLDVQSYSVWLPYQ 1126
            |..:.......:|:|                    :.:|:||..     ....|:|:.|..||..
Human  1470 NNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLS 1534

  Fly  1127 AIDPYYPF------------------ENRSVEDFTIGTEN---------CDNHKI--GYCNGPLK 1162
            .....:..                  ||.:..||:....|         ..:.:|  |:...|..
Human  1535 PESKAWAVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTS 1599

  Fly  1163 SGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTII-------LVLLVTLLFYK 1220
            |.|:...:|...:.|:. :::::...|...:...|...|: :||.|:       ||:||.:|.|.
Human  1600 SVTSENSEVFHVSEAEA-SNSSHESRIGLAEGLESEKKAV-IPLVIVSALTFICLVVLVGILIYW 1662

  Fly  1221 RRRNNCRKTT----KDSRANDNMSLPDSVI----EQNRPILIKNFAEHYRLMSADSDFRFSEEFE 1277
            |:   |.:|.    :||.:...:|.|.:.|    :....|.||:|.:|...:.|.|.  |:||||
Human  1663 RK---CFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSG--FTEEFE 1722

  Fly  1278 ELKHVGRD-QPCTFADL---------PCNRPKNRFTNILPYDHSRFKLQPVDDDEG--SDYINAN 1330
            .||...:: |.|| .||         |.|:.|||:.||:.|||||.||..:.:.:|  :||||||
Human  1723 TLKEFYQEVQSCT-VDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINAN 1786

  Fly  1331 YVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYG 1395
            ||.|:|.|:.:|..||||.||.:|||||.||.|...|||:|...||||.|||||||.|.... ||
Human  1787 YVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEE-YG 1850

  Fly  1396 DI-----KVQILNDSHYADWVMTEFMLCRGSEQ-----RILRHFHFTTWPDFGVPNPPQTLVRFV 1450
            :.     .||:|......::.:....:.:||::     |::..:|:|.|||.|||.....::.||
Human  1851 NFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFV 1915

  Fly  1451 R----AFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMV 1511
            |    |.|..:|    |:||||||||||:||:|.||.:||||.....|:|||.:..:|.:|.::|
Human  1916 RKAAYAKRHAVG----PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLV 1976

  Fly  1512 QTEQQYICIHQCLLAVLEGKEN---------------IVGPAREMHDNEGYEGQQVQLDENGDVV 1561
            |||:||:.||..|:..:..||.               |.|||.:....     :|.||       
Human  1977 QTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLE-----KQFQL------- 2029

  Fly  1562 ATIEGHLSHHDLQQAEAEAIDDENAAILHDDQQ--------PLTSSFTGHHTHMPPTTSMSSFGG 1618
                  ||..::||:      |.:||:...:::        |:..|..|          :||..|
Human  2030 ------LSQSNIQQS------DYSAALKQCNREKNRTSSIIPVERSRVG----------ISSLSG 2072

  Fly  1619 GGGGHTN----VDAPDRXHSVVNQS--------------DNNNSVVIVLVD-------------N 1652
            .|..:.|    :........::.|.              |:|..:|:::.|             |
Human  2073 EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPN 2137

  Fly  1653 KPSSMICKDSK 1663
            |...:.|:..|
Human  2138 KDEPINCESFK 2148

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 12/80 (15%)
fn3 220..304 CDD:278470 20/101 (20%)
fn3 315..391 CDD:278470 16/96 (17%)
FN3 405..494 CDD:238020 22/116 (19%)
FN3 511..574 CDD:238020 15/85 (18%)
FN3 583..671 CDD:238020 25/140 (18%)
fn3 683..753 CDD:278470 16/69 (23%)
fn3 787..850 CDD:278470 16/78 (21%)
fn3 866..935 CDD:278470 11/71 (15%)
fn3 961..1043 CDD:278470 24/175 (14%)
PTPc 1272..1525 CDD:214550 125/278 (45%)
PTPc 1298..1525 CDD:238006 111/242 (46%)
PTPRZ1NP_002842.2 PARM 1089..>1255 CDD:293666 31/184 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1123..1160 6/51 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1397..1523 14/125 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1543..1572 4/28 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1584..1621 7/37 (19%)
PTPc 1716..1991 CDD:214550 126/282 (45%)
PTPc 1752..1991 CDD:238006 112/243 (46%)
Substrate binding. /evidence=ECO:0000250 1933..1939 5/5 (100%)
PTPc 2022..2280 CDD:214550 27/161 (17%)
PTPc 2050..2280 CDD:238006 17/109 (16%)
alpha_CARP_receptor_like 45..298 CDD:239396 21/145 (14%)
fn3 313..401 CDD:278470 21/106 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..462 1/19 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..507 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 628..650 6/21 (29%)
MFMR 684..>763 CDD:285072 9/78 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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