| Sequence 1: | NP_996413.2 | Gene: | Ptp10D / 32115 | FlyBaseID: | FBgn0004370 | Length: | 1990 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_002841.3 | Gene: | PTPRS / 5802 | HGNCID: | 9681 | Length: | 1948 | Species: | Homo sapiens |
| Alignment Length: | 1696 | Identity: | 391/1696 - (23%) |
|---|---|---|---|
| Similarity: | 616/1696 - (36%) | Gaps: | 534/1696 - (31%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 112 WLTWTVTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVND 176
Fly 177 NTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPY 241
Fly 242 PAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTA 306
Fly 307 QYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAFFDF 371
Fly 372 RDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWE--ADPASTQ 434
Fly 435 DEYRIVY-----HEL---ETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESN-ETSI 490
Fly 491 FVVTR---PSSPIIEDLKS---IRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKE--SR 547
Fly 548 LVIKNLQPGAGYELKVFAVS-------------HDLRSEPHAYFQAVYPNPPRNMTIETVRSNSV 599
Fly 600 LVHWSPP----ESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVE 660
Fly 661 SPVPQEVNTTVPPNPVSNIIQLVDSRNITLEW--------------PKPEG-----RVESYILKW 706
Fly 707 WPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGI----LSGITSLYPRT 767
Fly 768 MPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFT 832
Fly 833 GLVPGRLYNITV--WTVSG-GVASLP--IQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYN 892
Fly 893 D----FDIAYLTADNLLAQNM---TTRNEITISDLRPHRNYTFTVVVRS----GTESSVLRSSSP 946
Fly 947 LSASFTTNEAVPGRVERFHPT------DVQPSEINFEWSLP-SSEANGVIRQFSIAYTNINNLTD 1004
Fly 1005 AGMQDFESEEAFG-----VIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPP-RPAT--- 1060
Fly 1061 -QVVPTE-----VYRSSSTIQIRFRKNYFS-------------DQNGQVRMYTI----------I 1096
Fly 1097 VAEDDAKNASGLE--MPSW--------------------------------LDVQSY-SVWLPY- 1125
Fly 1126 -----QAIDPYYPFENRSVEDFTIGTENCDNHKI------------------------------- 1154
Fly 1155 --GYCNGPLKSGTTYRVKVRAFTGADK--FTDTAYSFPIQTD----------QDNTSLIVAITVP 1205
Fly 1206 LTIILVLLVTLLFYKRRRNNCRKTT------------------KD--SRANDNMSLPDSVIE--- 1247
Fly 1248 -----------QNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNR 1301
Fly 1302 FTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRA 1366
Fly 1367 IVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHF 1429
Fly 1430 HFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYV 1494
Fly 1495 DIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDENGD 1559
Fly 1560 VVATIE 1565 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Ptp10D | NP_996413.2 | fn3 | 124..205 | CDD:278470 | 15/80 (19%) |
| fn3 | 220..304 | CDD:278470 | 13/83 (16%) | ||
| fn3 | 315..391 | CDD:278470 | 12/75 (16%) | ||
| FN3 | 405..494 | CDD:238020 | 25/99 (25%) | ||
| FN3 | 511..574 | CDD:238020 | 16/77 (21%) | ||
| FN3 | 583..671 | CDD:238020 | 23/91 (25%) | ||
| fn3 | 683..753 | CDD:278470 | 17/88 (19%) | ||
| fn3 | 787..850 | CDD:278470 | 11/65 (17%) | ||
| fn3 | 866..935 | CDD:278470 | 14/79 (18%) | ||
| fn3 | 961..1043 | CDD:278470 | 21/93 (23%) | ||
| PTPc | 1272..1525 | CDD:214550 | 119/254 (47%) | ||
| PTPc | 1298..1525 | CDD:238006 | 113/228 (50%) | ||
| PTPRS | NP_002841.3 | Ig | 32..120 | CDD:299845 | |
| I-set | 33..124 | CDD:254352 | |||
| Important for binding to glycosaminoglycan chains. /evidence=ECO:0000250|UniProtKB:B0V2N1 | 68..72 | ||||
| IG_like | 141..234 | CDD:214653 | |||
| Ig2_RPTP_IIa_LAR_like | 152..235 | CDD:143215 | |||
| IG_like | 251..328 | CDD:214653 | 14/70 (20%) | ||
| Ig3_RPTP_IIa_LAR_like | 259..327 | CDD:143216 | 14/69 (20%) | ||
| FN3 | 332..421 | CDD:238020 | 25/169 (15%) | ||
| FN3 | 428..520 | CDD:238020 | 28/108 (26%) | ||
| FN3 | 525..613 | CDD:238020 | 17/90 (19%) | ||
| FN3 | 621..715 | CDD:238020 | 29/136 (21%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 700..724 | 6/27 (22%) | |||
| FN3 | 723..828 | CDD:238020 | 33/155 (21%) | ||
| FN3 | 838..920 | CDD:238020 | 15/83 (18%) | ||
| FN3 | 932..1029 | CDD:238020 | 23/106 (22%) | ||
| FN3 | 1037..>1097 | CDD:238020 | 9/59 (15%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1311..1340 | 4/28 (14%) | |||
| PTPc | 1392..1647 | CDD:214550 | 120/256 (47%) | ||
| PTPc | 1418..1647 | CDD:238006 | 114/229 (50%) | ||
| Substrate binding. /evidence=ECO:0000250 | 1589..1595 | 5/5 (100%) | |||
| PTPc | 1679..1938 | CDD:214550 | 1/3 (33%) | ||
| PTPc | 1708..1938 | CDD:238006 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3031 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.940 | |||||