DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and PTPRS

DIOPT Version :10

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:NP_002841.3 Gene:PTPRS / 5802 HGNCID:9681 Length:1948 Species:Homo sapiens


Alignment Length:1696 Identity:391/1696 - (23%)
Similarity:616/1696 - (36%) Gaps:534/1696 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   112 WLTWTVTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVND 176
            |:.....:|...|.|        .|:|.:.|.......:||...:..||:.||.:          
Human   278 WMQGAEDLTPEDDMP--------VGRNVLELTDVKDSANYTCVAMSSLGVIEAVA---------- 324

  Fly   177 NTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPY 241
               |.:||.|                              |..||..:|.....|::.:.|....
Human   325 ---QITVKSL------------------------------PKAPGTPMVTENTATSITITWDSGN 356

  Fly   242 PAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTA 306
            |                 |.|.|                       |.|..::.|:|        
Human   357 P-----------------DPVSY-----------------------YVIEYKSKSQD-------- 373

  Fly   307 QYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAFFDF 371
                   .|..:..|   ||:..:.:     .|:|...:|::.|:........|.|.        
Human   374 -------GPYQIKED---ITTTRYSI-----GGLSPNSEYEIWVSAVNSIGQGPPSE-------- 415

  Fly   372 RDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWE--ADPASTQ 434
                      :|:.:|  |:.....|..:|..|.|           ...|||:.||  .:|....
Human   416 ----------SVVTRT--GEQAPASAPRNVQARML-----------SATTMIVQWEEPVEPNGLI 457

  Fly   435 DEYRIVY-----HEL---ETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESN-ETSI 490
            ..||:.|     |.:   :..|.|.|.||      |:.|||....|::.|.|.:...:.. ...|
Human   458 RGYRVYYTMEPEHPVGNWQKHNVDDSLLT------TVGSLLEDETYTVRVLAFTSVGDGPLSDPI 516

  Fly   491 FVVTR---PSSPIIEDLKS---IRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKE--SR 547
            .|.|:   |..|:  :|::   ....:.:||.........:||:|: |.|.......:|.:  :.
Human   517 QVKTQQGVPGQPM--NLRAEARSETSITLSWSPPRQESIIKYELLF-REGDHGREVGRTFDPTTS 578

  Fly   548 LVIKNLQPGAGYELKVFAVS-------------HDLRSEPHAYFQAVYPNPPRNMTIETVRSNSV 599
            .|:::|:|...|..::.|.|             ..|:|:|.|        ||:::...:|||.::
Human   579 YVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSA--------PPQDVKCVSVRSTAI 635

  Fly   600 LVHWSPP----ESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVE 660
            ||.|.||    .:|....||:|||                                    ..|.|
Human   636 LVSWRPPPPETHNGALVGYSVRYR------------------------------------PLGSE 664

  Fly   661 SPVPQEVNTTVPPNPVSNIIQLVDSRNITLEW--------------PKPEG-----RVESYILKW 706
            .|.|:||| .:||.....:::.::      :|              |.||.     |.:..:   
Human   665 DPEPKEVN-GIPPTTTQILLEALE------KWTQYRITTVAHTEVGPGPESSPVVVRTDEDV--- 719

  Fly   707 WPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGI----LSGITSLYPRT 767
             ||..|.:|:.:       |.:.:.:|||.....||.|:.   |...|.:    :.|..:..|  
Human   720 -PSAPPRKVEAE-------ALNATAIRVLWRSPAPGRQHG---QIRGYQVHYVRMEGAEARGP-- 771

  Fly   768 MPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFT 832
             |.|: ||::|:.:.|.: ||                                    .:.::..|
Human   772 -PRIK-DVMLADAQWETD-DT------------------------------------AEYEMVIT 797

  Fly   833 GLVPGRLYNITV--WTVSG-GVASLP--IQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYN 892
            .|.|...|:|||  :|:.| |..|.|  :..:..:...|...:..|  .:..:..||:.|.|...
Human   798 NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQT--PEGSLLARWEPPAGTAE 860

  Fly   893 D----FDIAYLTADNLLAQNM---TTRNEITISDLRPHRNYTFTVVVRS----GTESSVLRSSSP 946
            |    :.:.:...|:.....:   .:.:..|.|.:.....|.|.:..||    |.|::.:.|   
Human   861 DQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLS--- 922

  Fly   947 LSASFTTNEAVPGRVERFHPT------DVQPSEINFEWSLP-SSEANGVIRQFSIAYTNINNLTD 1004
                      :|....|.||.      :.....:...|..| .:|.||.|.::::|......|..
Human   923 ----------IPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGP 977

  Fly  1005 AGMQDFESEEAFG-----VIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPP-RPAT--- 1060
            |...:..:....|     .::.|||...|..:::|.|..|.||          .:|| |..|   
Human   978 ARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP----------FSPPVRYRTFLR 1032

  Fly  1061 -QVVPTE-----VYRSSSTIQIRFRKNYFS-------------DQNGQVRMYTI----------I 1096
             ||.|..     :.::|..:...|..||.|             |.:|:.....|          .
Human  1033 DQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNF 1097

  Fly  1097 VAEDDAKNASGLE--MPSW--------------------------------LDVQSY-SVWLPY- 1125
            |..:...:..||:  :.:|                                :.|||| .|.:|. 
Human  1098 VLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLR 1162

  Fly  1126 -----QAIDPYYPFENRSVEDFTIGTENCDNHKI------------------------------- 1154
                 |.:.|....|:..:|:............:                               
Human  1163 KSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQ 1227

  Fly  1155 --GYCNGPLKSGTTYRVKVRAFTGADK--FTDTAYSFPIQTD----------QDNTSLIVAITVP 1205
              |:.|..|:.|..|.:.|.|.....:  |..:.:|.|.|.|          ::....::...:.
Human  1228 YGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLA 1292

  Fly  1206 LTIILVLLVTLLFYKRRRNNCRKTT------------------KD--SRANDNMSLPDSVIE--- 1247
            :..|:.:::.:|.||.:.::.||.:                  ||  .....|...|||.:.   
Human  1293 VVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPL 1357

  Fly  1248 -----------QNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNR 1301
                       .:.||.|.:.|||...:.|:...:.|:|:|.: ..|:......::|..|:||||
Human  1358 REPGFHFESMLSHPPIPIADMAEHTERLKANDSLKLSQEYESI-DPGQQFTWEHSNLEVNKPKNR 1421

  Fly  1302 FTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRA 1366
            :.|::.|||||..|||::...||||||||||.|:.....:|.|||||..|..|||||.||..|..
Human  1422 YANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSAT 1486

  Fly  1367 IVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRILRHF 1429
            |||:||..||.|.||||||||..... ||.|:|.:|:....|.:.:..|.|.:  .||:|.:|.|
Human  1487 IVMMTRLEEKSRIKCDQYWPNRGTET-YGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQF 1550

  Fly  1430 HFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYV 1494
            .||.|||.|||..|...:.|:|..:.....:..||||||||||||:|.||.:|.:|::|.....|
Human  1551 QFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTV 1615

  Fly  1495 DIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDENGD 1559
            |::|.|..||.:|.:|||||.||..||:.||..: |..|...|||.::   .|..:..|: |.|:
Human  1616 DVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV-GCGNTEVPARSLY---AYIQKLAQV-EPGE 1675

  Fly  1560 VVATIE 1565
            .|..:|
Human  1676 HVTGME 1681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:394996 15/80 (19%)
fn3 220..304 CDD:394996 13/83 (16%)
FN3 278..>734 CDD:442628 102/510 (20%)
FN3 583..671 CDD:238020 23/91 (25%)
fn3 787..850 CDD:394996 11/65 (17%)
fn3 866..935 CDD:394996 14/79 (18%)
fn3 959..1043 CDD:394996 21/95 (22%)
PTP_tm 1083..1187 CDD:465889 26/202 (13%)
R3-PTPc 1301..1522 CDD:350396 109/222 (49%)
PTPRSNP_002841.3 I-set 33..124 CDD:400151
Ig strand B 50..54 CDD:409353
Ig strand C 63..67 CDD:409353
Important for binding to glycosaminoglycan chains. /evidence=ECO:0000250|UniProtKB:B0V2N1 68..72
Ig strand E 86..93 CDD:409353
Ig strand F 104..109 CDD:409353
Ig strand G 117..120 CDD:409353
IgI_2_RPTP_IIa_LAR_like 137..235 CDD:409400
Ig strand A' 143..147 CDD:409400
Ig strand B 150..159 CDD:409400
Ig strand C 164..170 CDD:409400
Ig strand C' 172..174 CDD:409400
Ig strand D 183..187 CDD:409400
Ig strand E 199..204 CDD:409400
Ig strand F 213..220 CDD:409400
Ig strand G 223..234 CDD:409400
IgI_3_RPTP_IIa_LAR_like 248..329 CDD:409401 14/71 (20%)
Ig strand A 248..250 CDD:409401
Ig strand A' 254..258 CDD:409401
Ig strand B 261..269 CDD:409401
Ig strand C 274..280 CDD:409401 1/1 (100%)
Ig strand C' 282..284 CDD:409401 0/1 (0%)
Ig strand D 287..291 CDD:409401 0/3 (0%)
Ig strand E 296..301 CDD:409401 1/4 (25%)
Ig strand F 308..315 CDD:409401 2/6 (33%)
FN3 318..>724 CDD:442628 116/606 (19%)
Ig strand G 319..328 CDD:409401 3/21 (14%)
FN3 <671..>981 CDD:442628 74/386 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 700..724 6/27 (22%)
FN3 1037..>1097 CDD:238020 9/59 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1340 4/28 (14%)
R-PTPc-S-1 1370..1651 CDD:350473 128/283 (45%)
R-PTP-S-2 1653..1942 CDD:350475 10/33 (30%)
Blue background indicates that the domain is not in the aligned region.

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