DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and PTPRR

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_002840.2	Gene:	PTPRR / 5801	HGNCID:	9680	Length:	657	Species:	Homo sapiens

Alignment Length:	733	Identity:	181/733 - (24%)
Similarity:	297/733 - (40%)	Gaps:	161/733 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   820 KLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYP----EPITQLHATNITDTEI 880
            |.:.|.::.:   .:.|.::|..:..:.|....|...|..:..:|    :|...|.|.:..|.|:
Human    45 KHSQDIEKSL---DIAPQKIYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEV 106

  Fly   881 SLRWDLPKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSS 945
            .   :||           :.|.|::...:    ::.::.|    |.|...:.|.|..:::    .
Human   107 E---NLP-----------IPAANVIVVTL----QMDVNKL----NITLLRIFRQGVAAAL----G 145

  Fly   946 PLSASFTTNEAV--PGRVERFHPTDVQP--SEINFEWSLPSSEANGVIRQFSIAYTNI--NNLTD 1004
            .|......|..:  ...:|.|    |.|  .:.....:|||.|   |:|..:|   |:  .:|:.
Human   146 LLPQQVHINRLIGKKNSIELF----VSPINRKTGISDALPSEE---VLRSLNI---NVLHQSLSQ 200

  Fly  1005 AGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYR 1069
            .|:.:...|      ||:..|:....||.:|.  ||.....:.....|:.       .....:||
Human   201 FGITEVSPE------KNVLQGQHEADKIWSKE--GFYAVVIFLSIFVIIV-------TCLMILYR 250

  Fly  1070 SSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGL----EMPSWLDVQSYSVWLPYQAIDP 1130
            .....|:..|::...:|...:...|:..|..:||....:    :.|..|:|          .:||
Human   251 LKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNV----------VVDP 305

  Fly  1131 YYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDN 1195
                :.|...:....|..      ..|..|.|...   :.::...|::          :....|.
Human   306 ----QGRGAPEIKATTAT------SVCPSPFKMKP---IGLQERRGSN----------VSLTLDM 347

  Fly  1196 TSL-----IVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIK 1255
            :||     .|:|..|               |.:.........||......|.|.|
Human   348 SSLGNIEPFVSIPTP---------------REKVAMEYLQSASRILTRSQLRDVV---------- 387

  Fly  1256 NFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFA-----DLPCNRPKNRFTNILPYDHSRFKL 1315
              |..:.|.|         ||.|:       |..|.     |:|.:..|||:..|||...||..|
Human   388 --ASSHLLQS---------EFMEI-------PMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCL 434

  Fly  1316 QPVD-DDEGSDYINANYVPGHN-SPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGR 1378
            :|.: .|..|.||||||:.|:: ..:.||.||||:.:|.||||:|.|:.:|..|||:|:..|| .
Human   435 RPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-N 498

  Fly  1379 EKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPP 1443
            |||..|||...  ..||.::|.:::.:...::.:...:|.:||..:.::|:.:|:|||...|:..
Human   499 EKCVLYWPEKR--GIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSA 561

  Fly  1444 QTLVR-FVRAFRDRIGAEQR-PIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKE 1506
            |.|:: .:....||:.::.| |:|||||||:||:|.||......||:.....||...||..:|.:
Human   562 QPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMD 626

  Fly  1507 RVWMVQTEQQYICIHQCL 1524
            |..||||.:||..:|..|
Human   627 RGGMVQTSEQYEFVHHAL 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470	5/29 (17%)
		fn3	866..935	CDD:278470	13/68 (19%)
		fn3	961..1043	CDD:278470	23/85 (27%)
		PTPc	1272..1525	CDD:214550	98/262 (37%)
		PTPc	1298..1525	CDD:238006	91/231 (39%)
PTPRR	NP_002840.2	PTPc	392..644	CDD:214550	99/270 (37%)
PTPRR	NP_002840.2	PTPc	417..644	CDD:238006	90/229 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910