DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and PTPRO

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_109592.1	Gene:	PTPRO / 5800	HGNCID:	9678	Length:	1216	Species:	Homo sapiens

Alignment Length:	1587	Identity:	374/1587 - (23%)
Similarity:	560/1587 - (35%)	Gaps:	565/1587 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 EPNTTIASREIGDEIQ----FSRALPGTKYNFWLYYTNFTHHDWLTWTVTITTAPDPPSNLSVQV 133
            :.|..:.|.|..|.|.    :...:.|...|::..:..|.           :|.|.|
Human    36 DDNNIVVSLEASDVISPASVYVVKITGESKNYFFEFEEFN-----------STLPPP-------- 81

  Fly   134 RSGKNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVNDNTF---QHSVKELTPGATYQVQ 195
                   :::.....|.|....:.|               ||.|..   ..|:..||  ....|.
Human    82 -------VIFKASYHGLYYIITLVV---------------VNGNVVTKPSRSITVLT--KPLPVT 122

  Fly   196 AYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDAND 260
            :.:|||.|.|           |.|.              ||::..||.......:|:|...:..|
Human   123 SVSIYDYKPS-----------PETG--------------VLFEIHYPEKYNVFTRVNISYWEGKD 162

  Fly   261 --SVLYVEKEGEPPGPAQAAFKG------LVPGRAY-NISVQTMSEDEISLPTTAQY-------- 308
              ::||.:           .|||      .:||..| ||:.|.:||...:..|..:|
Human   163 FRTMLYKD-----------FFKGKTVFNHWLPGMCYSNITFQLVSEATFNKSTLVEYSGVSHEPK 216

  Fly   309 --RTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVAT---------TRRQSTVPRS 362
              ||.|..|.|::.....:..|:    ||...|....:.:..|..|         |.....:|..
Human   217 QHRTAPYPPQNISVRIVNLNKNN----WEEQSGNFPEESFMRSQDTIGKEKLFHFTEETPEIPSG 277

  Fly   363 NEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGD------------VTLRPLPVRNLRSIN 415
            |....:.||              .:...:.||.|...|            |::.|:...|..:::
Human   278 NISSGWPDF--------------NSSDYETTSQPYWWDSASAAPESEDEFVSVLPMEYENNSTLS 328

  Fly   416 DDKTNT----------MIITW-EADPASTQDEYRIVYHELETFNGDTSTLTTDRT--RFTLESLL 467
            :.:.:|          ||:|| ...|.:..|.:.|.....|.|   |..|..|..  .|..|...
Human   329 ETEKSTSGSFSFFPVQMILTWLPPKPPTAFDGFHIHIEREENF---TEYLMVDEEAHEFVAELKE 390

  Fly   468 PGRNYSLSVQAVS-------KKMESNETSIFVVTRPSSPIIEDL--KSIRMGLNI--------SW 515
            ||: |.|||...|       :|.:|.::..|.:: ||...||:|  |...:.:::        ||
Human   391 PGK-YKLSVTTFSSSGSCETRKSQSAKSLSFYIS-PSGEWIEELTEKPQHVSVHVLSSTTALMSW 453

  Fly   516 KSDVNSKQEQYEVLYSRNGT----SDLRTQKTKES-RL-------------VIKNLQPGAGYELK 562
                .|.||.|      |.|    ..|..||.||| ||             :|:||.|||.|::.
Human   454 ----TSSQENY------NSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVV 508

  Fly   563 VFAVSHDL---RSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRY----RT 620
            ::.....|   .|:|..:  |:.|...:::.:..:...:|::.|:.|..|.|.:|.:..    ..
Human   509 IYLRKGPLIGPPSDPVTF--AIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVFRKYVVEMFYFNPA 571

  Fly   621 DSEQQWVRLPSVRST-----EADITDMTKGEKYTIQVNTVSFG--------------VESPVPQE 666
            ....:|.....:.:|     ...|.::.....|..:|..|::|              :.:||..|
Human   572 TMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVTWGDPELSCCDSSTISFITAPVAPE 636

  Fly   667 VNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLST 731
            :.:             |:..|..|           || .|...|:              ..|||.
Human   637 ITS-------------VEYFNSLL-----------YI-SWTYGDD--------------TTDLSH 662

  Fly   732 VRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPT 796
            .|:|                                     ..:|||.|
Human   663 SRML-------------------------------------HWMVVAEG---------------- 674

  Fly   797 PQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKV--TFTGLVPGRLYNITVWTVSGGVASLPIQRQ 859
                                 |:|:.....|.|  ....|.||.:||::|...:...::..:.|.
Human   675 ---------------------KKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRL 718

  Fly   860 DRLYPEPITQLHATNITDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNMTTRNE--------IT 916
            .:|.|.|...|.|.|.|.|.::|.| :.:|..:.|::   ....:.:...|...|        :|
Human   719 VKLEPAPPKSLFAVNKTQTSVTLLW-VEEGVADFFEV---FCQQVGSSQKTKLQEPVAVSSHVVT 779

  Fly   917 ISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLP 981
            ||.|.|...|..:|.           |.|..|.|..|..||...|...:|..|..|
Human   780 ISSLLPATAYNCSVT-----------SFSHDSPSVPTFIAVSTMVTEMNPNVVVIS--------- 824

  Fly   982 SSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREY 1046
                                             ...::..|..|...|
Human   825 ---------------------------------VLAILSTLLIGLLLV----------------- 839

  Fly  1047 RQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNY--FSDQNGQVRMYTIIVAEDDAKNASGLE 1109
              |:.||                         ||.:  .:.:.|..........|.|.|
Human   840 --TLIIL-------------------------RKKHLQMARECGAGTFVNFASLERDGK------ 871

  Fly  1110 MPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAF 1174
                         |||.        ..||:..|.....:|
Human   872 -------------LPYN--------WRRSIFAFLTLLPSC------------------------- 890

  Fly  1175 TGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNM 1239
                .:||...:|.|.....|.                     ..||:..|
Human   891 ----LWTDYLLAFYINPWSKNG---------------------LKKRKLTN-------------- 916

  Fly  1240 SLPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTN 1304
                       |:.:.:|..:.:.|:.|||::||.:|||||.:|.|.|...||||.||.|||:||
Human   917 -----------PVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTN 970

  Fly  1305 ILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVM 1369
            |||||.||.:|..::::||:|||||||:||:|||:|:|.|||||..||:|||:|..:..|:.|||
Human   971 ILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVM 1035

  Fly  1370 LTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTW 1434
            ||:|.||.|.|||.|||....|:.||||.|:::::....||....|.:....|.:.:.||::|.|
Human  1036 LTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAW 1100

  Fly  1435 PDFGVP--NPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIF 1497
            ||.|||  |..:::::||...|.:....:.|:::||||||||:||||.|||:||.|...::|||.
Human  1101 PDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDIL 1165

  Fly  1498 GIVYAMRKERVWMVQTEQQYICIHQCL 1524
            |:|..||..|:.|||||:|||.||||:
Human  1166 GLVSEMRSYRMSMVQTEEQYIFIHQCV 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	15/83 (18%)
		fn3	220..304	CDD:278470	20/92 (22%)
		fn3	315..391	CDD:278470	13/84 (15%)
		FN3	405..494	CDD:238020	27/108 (25%)
		FN3	511..574	CDD:238020	25/91 (27%)
		FN3	583..671	CDD:238020	17/110 (15%)
		fn3	683..753	CDD:278470	12/69 (17%)
		fn3	787..850	CDD:278470	10/64 (16%)
		fn3	866..935	CDD:278470	19/76 (25%)
		fn3	961..1043	CDD:278470	7/81 (9%)
		PTPc	1272..1525	CDD:214550	134/255 (53%)
		PTPc	1298..1525	CDD:238006	118/229 (52%)
PTPRO	NP_109592.1	fn3	435..521	CDD:306538	25/95 (26%)
		FN3	530..630	CDD:238020	14/99 (14%)
		fn3	725..805	CDD:306538	23/94 (24%)
		PTPc	965..1193	CDD:238006	118/228 (52%)
		Substrate binding. /evidence=ECO:0000250	1136..1142		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146161
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.710