DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and PTPRN

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_002837.1	Gene:	PTPRN / 5798	HGNCID:	9676	Length:	979	Species:	Homo sapiens

Alignment Length:	1151	Identity:	248/1151 - (21%)
Similarity:	393/1151 - (34%)	Gaps:	368/1151 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 RP----SSPIIEDLKSI---RMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKN 552
            ||    :||:::.|:.:   .|...:||..|:                    ||
Human    70 RPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDL--------------------TQ----------- 103

  Fly   553 LQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIR 617
                       :.:|.::...|.     :.|..||      .|..|.|....|..:||.....|.
Human   104 -----------YVISQEMERIPR-----LRPPEPR------PRDRSGLAPKRPGPAGELLLQDIP 146

  Fly   618 YRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEV------NTTVPPNPV 676
            ..:....|. |||     :..:.....|...::          ||:..|:      :..:||.|
Human   147 TGSAPAAQH-RLP-----QPPVGKGGAGASSSL----------SPLQAELLPPLLEHLLLPPQP- 194

  Fly   677 SNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMP 741
                            |.|....|..:|:.:.....|......|||.      |...|.:|.| |
Human   195 ----------------PHPSLSYEPALLQPYLFHQFGSRDGSRVSEG------SPGMVSVGPL-P 236

  Fly   742 GVQYKFDIQTT------------SYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYT 794
            ..:.......|            |||.|.|     |....|.|...::...::........:...
Human   237 KAEAPALFSRTASKGIFGDHPGHSYGDLPG-----PSPAQLFQDSGLLYLAQELPAPSRARVPRL 296

  Fly   795 PTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQ 859
            |...|||:.:      ...|..:||.| .|...|.....:.|..........::|....|   ||
Human   297 PEQGSSSRAE------DSPEGYEKEGL-GDRGEKPASPAVQPDAALQRLAAVLAGYGVEL---RQ 351

  Fly   860 DRLYPEPITQLHATNITDTEISLRWDLPKGE-YNDFDIAYLTADNLLAQNMTTRNEITISDLRPH 923
              |.||.::.|         ::|...||||. .|...:..:.||
Human   352 --LTPEQLSTL---------LTLLQLLPKGAGRNPGGVVNVGAD--------------------- 384

  Fly   924 RNYTFTVVVRSGTESSVL-RSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANG 987
                    ::...|..|. |.::.|.|   ....:||     ||| ..|:         |||...
Human   385 --------IKKTMEGPVEGRDTAELPA---RTSPMPG-----HPT-ASPT---------SSEVQQ 423

  Fly   988 VIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPI 1052
            |....|                  ||..    |..:|..|.|. ::.|:.:|        |:.|.
Human   424 VPSPVS------------------SEPP----KAARPPVTPVL-LEKKSPLG--------QSQPT 457

  Fly  1053 LA---PPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKN-ASGLEMPSW 1113
            :|   ..|||.:                              .|..||.:....: |:|:::
Human   458 VAGQPSARPAAE------------------------------EYGYIVTDQKPLSLAAGVKL--- 489

  Fly  1114 LDV------QSYSVWLPYQAIDPYYPF------ENRSVEDFTIGTENCDNHKIGYCNGPLKSGTT 1166
            |::      .|...::....:.|...|      :|.|:.|.|        .:.|.....|::.|.
Human   490 LEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVT--------QQAGLVKSELEAQTG 546

  Fly  1167 YRVKVRAFTGADKFTDTAYSFPIQTDQDNTSL------IVAITVPLTIILVLLVTLLFYKRRRNN 1225
            .::   ..||..:..:.|...| ||....:.:      :||:.....:::.|.|.|...:..|..
Human   547 LQI---LQTGVGQREEAAAVLP-QTAHSTSPMRSVLLTLVALAGVAGLLVALAVALCVRQHARQQ 607

  Fly  1226 ------------------------CRK--TTKD--SRA------------------------NDN 1238
                                    ||:  .||.  :||                        :.:
Human   608 DKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPEPSRVSSVSSQFSDAAQASPSSH 672

  Fly  1239 MSLP---DSVIEQNRPI-----LIKNFAEHYRLMSADSDFRFSEEFEEL-KHVGRDQPCTFADLP 1294
            .|.|   :...:.|..|     ::....:|.|    :.| |.::|::.| .:......|..|...
Human   673 SSTPSWCEEPAQANMDISTGHMILAYMEDHLR----NRD-RLAKEWQALCAYQAEPNTCATAQGE 732

  Fly  1295 CNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPR--EFIVTQGPLHSTRDDFWR 1357
            .|..|||..:.|||||:|.||:.......||||||:.:..|: ||  .:|.|||||..|..|||:
Human   733 GNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHD-PRMPAYIATQGPLSHTIADFWQ 796

  Fly  1358 MCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYA-DWVMTEFML--CR 1419
            |.|||....|||||...|.|.::||:|||::...: |...:|.::::..:. |:::..|.|  .:
Human   797 MVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASL-YHVYEVNLVSEHIWCEDFLVRSFYLKNVQ 860

  Fly  1420 GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRI 1484
            ..|.|.|..|||.:||..|.|...:.|:.|.|...........||:||||.|.||:||:|.:|.:
Human   861 TQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMV 925

  Fly  1485 LQQINTS-DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE 1529
            |.::... ..:||...:..:|.:|..:|:::.|:   ...|.||.|
Human   926 LNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQF---EFALTAVAE 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020	6/62 (10%)
		FN3	583..671	CDD:238020	18/93 (19%)
		fn3	683..753	CDD:278470	14/81 (17%)
		fn3	787..850	CDD:278470	11/62 (18%)
		fn3	866..935	CDD:278470	9/69 (13%)
		fn3	961..1043	CDD:278470	17/81 (21%)
		PTPc	1272..1525	CDD:214550	89/259 (34%)
		PTPc	1298..1525	CDD:238006	84/232 (36%)
PTPRN	NP_002837.1	RESP18 homology domain	35..131		19/113 (17%)
		RESP18	60..138	CDD:291609	20/120 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..173		16/77 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..329		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..439		18/85 (21%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000269\|PubMed:25561468	449..575		29/178 (16%)
		Receptor_IA-2	472..557	CDD:288410	17/98 (17%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000250\|UniProtKB:P80560	601..732		19/135 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..680		4/36 (11%)
		PTPc	709..968	CDD:214550	92/263 (35%)
		PTPc	736..968	CDD:238006	87/236 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910