Protein Alignment Ptp10D and PTPRM

DIOPT Version :9

• Sequence 1: NP_996413.2
• Gene: Ptp10D / 32115
• FlyBaseID: FBgn0004370
• Length: 1990
• Species: Drosophila melanogaster
• Sequence 2: XP_011524010.1
• Gene: PTPRM / 5797
• HGNCID: 9675
• Length: 1507
• Species: Homo sapiens
• Alignment Length: 1342
• Identity: 311/1342 - (23%)
• Similarity: 484/1342 - (36%)
• Gaps: 427/1342 - (31%)

  Fly   603 WSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESP----- 662
            |.|  ||.|...:...|.:.::..:.||.::..:....|.    .|     .||....||
Human    62 WMP--SGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDF----HY-----FVSSKSNSPPGLLN 115

  Fly   663 VPQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWP------------------- 708
            |..:||.....||:.||     |.:.|..|    .|.|..|..:||
Human   116 VYVKVNNGPLGNPIWNI-----SGDPTRTW----NRAELAISTFWPNFYQVIFEVITSGHQGYLA 171

  Fly   709 -----------SDNPGRVQTKNVSENKSADDLSTV------RVLIGE--LMPGV----------- 743
                       :..|..::.:||..|  |...:|.      |.:.|:  .:.|:
Human   172 IDEVKVLGHPCTRTPHFLRIQNVEVN--AGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIK 234

  Fly   744 ----------------------QYKFDIQTTSYGILSGITSLYPRTMPL---------------- 770
                                  :|:..|:|.....:|....|..:..|:
Human   235 VTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLW 299

  Fly   771 IQSDVVVANGE-----KEDERDTITLSYTP-TPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKV 829
            ||.:....||:     :|.|..|.:.|:.. .|..|:.:.|             ..|..||:.::
Human   300 IQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKI-------------GHLDPDTEYEI 351

  Fly   830 TFTGLVPGRLYNITVWTVSGGVASL-PIQRQDRLYPEPI---TQLHATNITDTEISLRWDLPKGE 890
            :.....||          .||..|. |..|......:|:   .:|....:...:|::||: |.|
Human   352 SVLLTRPG----------EGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWE-PFG- 404

  Fly   891 YNDFDIAYLTADNLLAQNMT------------TRNEI-----------TISDLRPHRNYTFTVVV 932
            ||        .....:.|:|            .|.|:           ||::|.|:.|.:..:::
Human   405 YN--------VTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLIL 461

  Fly   933 -----RSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTD-VQPS----EINFEWSLPSSEANG 987
                 |..::..:::          |:|.:||.|    ||: :|.|    :|..:|..| ::..|
Human   462 MNPEGRKESQELIVQ----------TDEDLPGAV----PTESIQGSTFEEKIFLQWREP-TQTYG 511

  Fly   988 VIRQFSIAYTNINNL-------TDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPERE 1045
            ||..:.|.|..:::.       ..:|.......|...:...|.||.||.|.|:|.||.||||...
Human   512 VITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPAT 576

  Fly  1046 YRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAED-DAKNASGLE 1109
            .:.|..|.||..||.: :.|.:.::.:|:.:..:..:  .:...|.:|.|:|.|: ..:.....|
Human   577 NQFTTKISAPSMPAYE-LETPLNQTDNTVTVMLKPAH--SRGAPVSVYQIVVEEERPRRTKKTTE 638

  Fly  1110 MPSWLDVQSYSVWLPYQAI----DPYY-----PFEN-RSVEDFTIGTENCDNHKIGYCNGPLKSG 1164
            :     ::.|.|.:.:|..    ..||     |.:: ::.:.||||.....|   ||.|.||...
Human   639 I-----LKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYN---GYWNTPLLPY 695

  Fly  1165 TTYR-----------------------------------VKVRAFTGADKFTDTAYSFPIQTDQD 1194
            .:||                                   :::....|..:.|..|...|:...:.
Human   696 KSYRIYFQAASRANGETKIDCVQVATKAAIIVTQLTTPYIRIAPAAGDGQLTGAATPKPVPEPEK 760

  Fly  1195 NTSLIVAIT-----VPLTIILVLLVTLLFYKRRRNNCRKTTKDS--------------------- 1233
            .|...|.|.     :.|.:|:.|.|.|:..||:....||.|..|
Human   761 QTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGT 825

  Fly  1234 ------------------------------------------------------------RANDN 1238
                                                                        .|:|.
Human   826 NCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILVPINDETHTMASDT 890

  Fly  1239 MSLPDSVIEQNR--------------PILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCT 1289
            .||..|...:.|              .|.:.:..:|...|.....:.|.||:|.. ..|:..|..
Human   891 SSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWD 954

  Fly  1290 FADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDD 1354
            .|....||.|||:.||:.|||||.:||.::.|..|||||.||:.|::.|..:|.||||:..|..|
Human   955 SAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYD 1019

  Fly  1355 FWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR 1419
            ||||.|..|:.:|:|:|...|.||.||.:|||:||  ..|.||||.::.....|::|:..|.:.:
Human  1020 FWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDT--EIYKDIKVTLIETELLAEYVIRTFAVEK 1082

  Fly  1420 GS-------------------EQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIV 1465
            |.                   |.|.:|.||||.|||.|||.....|:.|||..:.:......|:|
Human  1083 GGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLV 1147

  Fly  1466 VHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL-AVLE 1529
            ||||||.||:|.||.:|.:|........|||:..|..:|..||.|||||:||:.||..:| |.|.
Human  1148 VHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLC 1212

  Fly  1530 GKENIVGPAREM----HDNEGYEGQ--QVQLDENGDVVATIEGHLSHHDLQQA------------ 1576
            |..::  ||.::    :|....:.|  ..|:.|....:..:...|...|...|
Human  1213 GDTSV--PASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCM 1275

  Fly  1577 ---------------EAEAIDDENAAILHDDQQPLTSSFTGH 1603
                           :.|:.:..|||::...:||.....|.|
Human  1276 DILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQH 1317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020	17/72 (24%)
		fn3	683..753	CDD:278470	20/140 (14%)
		fn3	787..850	CDD:278470	10/63 (16%)
		fn3	866..935	CDD:278470	19/99 (19%)
		fn3	961..1043	CDD:278470	28/93 (30%)
		PTPc	1272..1525	CDD:214550	114/271 (42%)
		PTPc	1298..1525	CDD:238006	105/245 (43%)
PTPRM	XP_011524010.1	MAM	22..182	CDD:214533	29/139 (21%)
		MAM	27..182	CDD:99706	29/139 (21%)
		IG_like	192..278	CDD:214653	13/87 (15%)
		ig	192..274	CDD:278476	12/83 (14%)
		FN3	282..361	CDD:214495	17/101 (17%)
		FN3	383..477	CDD:238020	18/113 (16%)
		FN3	499..581	CDD:238020	24/82 (29%)
		PTPc	937..1208	CDD:214550	114/273 (42%)
		PTPc	964..1208	CDD:238006	105/245 (43%)
		PTPc	1240..1502	CDD:214550	13/78 (17%)
		PTPc	1270..1502	CDD:238006	8/48 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12196
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910