DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and PTPRJ

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_016873572.1	Gene:	PTPRJ / 5795	HGNCID:	9673	Length:	1363	Species:	Homo sapiens

Alignment Length:	1282	Identity:	333/1282 - (25%)
Similarity:	551/1282 - (42%)	Gaps:	261/1282 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   347 QVSVATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWP-ATGDVTLRPLPVRN 410
            |.|..|.......|.|.||:...|.|          |.:..|.....||. ..|..:.|.|
Human   215 QGSNGTDGASQKTPSSTEPIPVSDLR----------VALTGVRKAALSWSNGNGTASCRVL---- 265

  Fly   411 LRSINDDKTNTMIITWEADPASTQDEYRIVYHELETFNGDTSTLTTD-RTRFTLESLLPGRNYSL 474
            |.||                                  |....||.| |.:..:..|.||..|::
Human   266 LESI----------------------------------GSHEELTQDSRLQVNISGLKPGVQYNI 296

  Fly   475 S---VQAVSKK---------MESNETSIFVVTRPSSPIIEDLKSIRMGLNISWKSDVNSKQEQYE 527
            :   :|:...|         ::::.|.......|::|:.::
Human   297 NPYLLQSNKTKGDPLGTEGGLDASNTERSRAGSPTAPVHDE------------------------ 337

  Fly   528 VLYSRNGTSDLRT-QKTKESRLVIKNLQPGAGYELKVFA-VSHDLRSEPHAYFQAVYPNPPRNMT 590
               |..|..|..: |:::::.:::..|:||..|...|:: .::....:|.|...........::|
Human   338 ---SLVGPVDPSSGQQSRDTEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVT 399

  Fly   591 IETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTV 655
            ...:.:.|:.:.|...::...:.|:.:.....|.....| :|....|.|..:.....|.|.|..|
Human   400 AVNISATSLTLIWKVSDNESSSNYTYKIHVAGETDSSNL-NVSEPRAVIPGLRSSTFYNITVCPV 463

  Fly   656 SFGVESPVPQEVNTTVPPNPVSNI-IQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKN 719
            ...:|. .|..:....||.|||:. :.:|.:..|.|.|...:  .||:.:.          .|:.
Human   464 LGDIEG-TPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHD--AESFQMH----------ITQE 515

  Fly   720 VSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGIT-SLYPRTMPLIQSDVVVANGEKE 783
            .:.|...:..:...::||.|.||.:|.|:|.........|.: ::..||:|....|:.|.
Human   516 GAGNSRVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVV----- 575

  Fly   784 DERDTITLSYTPT---------PQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRL 839
                     |..|         |..:|:: :|...:   |.:......:..|:.:|..||:||.|
Human   576 ---------YVTTTEMWLDWKSPDGASEY-VYHLVI---ESKHGSNHTSTYDKAITLQGLIPGTL 627

  Fly   840 YNIT-------VWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYNDFDIA 897
            ||||       ||......|.         |..|      :|:::.::|.........:.:||.|
Human   628 YNITISPEVDHVWGDPNSTAQ---------YTRP------SNVSNIDVSTNTTAATLSWQNFDDA 677

  Fly   898 YLTADNLL----AQNMTTRNEI---------TISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSA 949
            ..|....|    |.|.:...::         |:::|.|..:||..:..:.|   ..::|..|...
Human   678 SPTYSYCLLIEKAGNSSNATQVVTDIGITDATVTELIPGSSYTVEIFAQVG---DGIKSLEPGRK 739

  Fly   950 SFTTNEAVPGRVERFHPTDVQPSE--INFEWSL-PSSEANGVIRQFSIAYTNINNLTDAGMQ--- 1008
            ||.|:   |..:..| ..:|.|.|  :..:|:. |.:.|...:...|.|:.|..:|.....:
Human   740 SFCTD---PASMASF-DCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGT 800

  Fly  1009 DFESEEAFGVIKNLKPGETYVFKIQAKTAIGFG----PEREYRQTMPILAPPRPATQVVPTEVYR 1069
            ::.:|..:     |....:|...|   |.:..|    |.|. ..|..|..||.|......|.|
Human   801 EYRTEVTY-----LNFSTSYNISI---TTVSCGKMAAPTRN-TCTTGITDPPPPDGSPNITSV-- 854

  Fly  1070 SSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQ-----AID 1129
            |.::::::|  :.|...:|.::.|.:|:...:|.:.|.       ||..|:    |:     |.|
Human   855 SHNSVKVKF--SGFEASHGPIKAYAVILTTGEAGHPSA-------DVLKYT----YEDFKKGASD 906

  Fly  1130 PYYPFENRSVE-------------DFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFT------ 1175
            .|..:..|:.|             :..:|.|:.   .:||.||.|:...:||..|..||
Human   907 TYVTYLIRTEEKGRSQSLSEVLKYEIDVGNEST---TLGYYNGKLEPLGSYRACVAGFTNITFHP 968

  Fly  1176 -------GADKFTD-TAYSFPIQTDQDNTSLIVAI--TVPLTIILVLLVTLLFYKRRRNNCRKTT 1230
                   ||:.:.. :.||..:...||...:..|:  .:...:::|.:...:|::::|
Human   969 QNKGLIDGAESYVSFSRYSDAVSLPQDPGVICGAVFGCIFGALVIVTVGGFIFWRKKR------- 1026

  Fly  1231 KDSRANDNMSLPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPC 1295
            ||:: |:.:|......::::.|.::||..:::...|||:..|:||:|:||.||..||...|:|..
Human  1027 KDAK-NNEVSFSQIKPKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAE 1090

  Fly  1296 NRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCW 1360
            ||.|||:.|:||||.||.||. |......|||||||:||::|.::||.|||||.:|..|||||.|
Human  1091 NRGKNRYNNVLPYDISRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVW 1154

  Fly  1361 ESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFML--CRGSEQ 1423
            |.|..||:|||:|.|:||.||::|||:.... .||||.|.:.::....:|.:.:|.:  .:.||.
Human  1155 EKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQ-DYGDITVAMTSEIVLPEWTIRDFTVKNIQTSES 1218

  Fly  1424 RILRHFHFTTWPDFGVPNPPQTLVRFVRAFRD--RIGAEQRPIVVHCSAGVGRSGTFITLDRILQ 1486
            ..||.||||:|||.|||:....|:.|....||  :....:.||:|||||||||:||||.:||::.
Human  1219 HPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIY 1283

  Fly  1487 QINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKEN 1533
            ||...:.||::||||.:|..|..|||||.||:.::||:|.::..:::
Human  1284 QIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD 1330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470	11/43 (26%)
		FN3	405..494	CDD:238020	16/101 (16%)
		FN3	511..574	CDD:238020	9/64 (14%)
		FN3	583..671	CDD:238020	15/87 (17%)
		fn3	683..753	CDD:278470	16/69 (23%)
		fn3	787..850	CDD:278470	19/78 (24%)
		fn3	866..935	CDD:278470	15/81 (19%)
		fn3	961..1043	CDD:278470	17/91 (19%)
		PTPc	1272..1525	CDD:214550	128/256 (50%)
		PTPc	1298..1525	CDD:238006	114/230 (50%)
PTPRJ	XP_016873572.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1621
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.910