Protein Alignment Ptp10D and PTPRG

DIOPT Version :9

• Sequence 1: NP_996413.2
• Gene: Ptp10D / 32115
• FlyBaseID: FBgn0004370
• Length: 1990
• Species: Drosophila melanogaster
• Sequence 2: XP_016862450.1
• Gene: PTPRG / 5793
• HGNCID: 9671
• Length: 1485
• Species: Homo sapiens
• Alignment Length: 1631
• Identity: 355/1631 - (21%)
• Similarity: 565/1631 - (34%)
• Gaps: 572/1631 - (35%)

  Fly   189 GATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPY---PAGIYTHYK 250
            |..||......:|.:.|      |.|...|| ||         |:.:|.:..|   .||:...:|
Human    96 GEEYQELQLDGFDNESS------NKTWMKNT-GK---------TVAILLKDDYFVSGAGLPGRFK 144

  Fly   251 VSIEPPDANDSVLYVEKE----GEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTV 311
                          .||.    |...|.|.:...  :.||.:.:..:.....:|.|..:...|.:
Human   145 --------------AEKVEFHWGHSNGSAGSEHS--INGRRFPVEAEDARGGDIMLMLSQGMRFI 193

  Fly   312 PLRPLNVTFD--RDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTV-------PRSNEPVA 367
            .|......|:  :.:.|..|.::.:..|   .:||.:|.:::..|....:       ||.|.
Human   194 LLGLKKEQFEERKSWTTYQSMQIFFYNP---DDFDSFQTAISENRIIGAMAIFFQVSPRDNS--- 252

  Fly   368 FFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEADPAS 432
                                              .|.|: :..|:.
Human   253 ----------------------------------ALDPI-IHGLKG------------------- 263

  Fly   433 TQDEYRIVYHELETFNGDTSTLTTDRTRFTLESLLP---GRNY----SLSVQAVSKKMESNETSI 490
                  :|:||.|||          ...|.|..|||   |..|    ||:....|:.:|
Human   264 ------VVHHEKETF----------LDPFVLRDLLPASLGSYYRYTGSLTTPPCSEIVE------ 306

  Fly   491 FVVTRPSSPI----IEDLKSIRMGLNISWKSDVNSKQEQY--EVLYSRNGTSDLRTQKTKESRLV 549
            ::|.|...||    :|...||           ..::|:.:  .|.|.||   :.|.|:....|:|
Human   307 WIVFRRPVPISYHQLEAFYSI-----------FTTEQQDHVKSVEYLRN---NFRPQQRLHDRVV 357

  Fly   550 IKN-LQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTE 613
            .|: ::....:::..| :.:.|.:|.    ..|..:||.:|.::.:...::.|.||.||
Human   358 SKSAVRDSWNHDMTDF-LENPLGTEA----SKVCSSPPIHMKVQPLNQTALQVSWSQPE------ 411

  Fly   614 YSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSN 678
                                                                    |:...|:.|
Human   412 --------------------------------------------------------TIYHPPIMN 420

  Fly   679 IIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGV 743
            .:       |:..|.|.|...|....|                     |....::..|..:.|..
Human   421 YM-------ISYSWTKNEDEKEKTFTK---------------------DSDKDLKATISHVSPDS 457

  Fly   744 QYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRF 808
            .|.|.:|..   ..:.:.|.:.:|| |.|     ||..:..:...|..:..||...:|..|:...
Human   458 LYLFRVQAV---CRNDMRSDFSQTM-LFQ-----ANTTRIFQGTRIVKTGVPTASPASSADMAPI 513

  Fly   809 SLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHAT 873
            |.|.                              :.||.||
Human   514 SSGS------------------------------STWTSSG------------------------ 524

  Fly   874 NITDTEISLRWDL-PKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTE 937
             |..:.:|:...: |....:...:|.:....|||                  ...|.....|...
Human   525 -IPFSFVSMATGMGPSSSGSQATVASVVTSTLLA------------------GLGFGGGGISSFP 570

  Fly   938 SSVLRSSSPLSAS---------FTTNEAV--PGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQ 991
            |:|..:..|.:||         ..|.||:  ||       .|...|        |:.:..|
Human   571 STVWPTRLPTAASASKQAARPVLATTEALASPG-------PDGDSS--------PTKDGEG---- 616

  Fly   992 FSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPP 1056
                       |:.|.:|.:||...|..::.:.||....| :.|:.:....| |..||.|...|.
Human   617 -----------TEEGEKDEKSESEDGEREHEEDGEKDSEK-KEKSGVTHAAE-ERNQTEPSPTPS 668

  Fly  1057 RP------ATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLD 1115
            .|      ..|.:|......::..         :||.|..|         ||......:|.:...
Human   669 SPNRTAEGGHQTIPGHEQDHTAVP---------TDQTGGRR---------DAGPGLDPDMVTSTQ 715

  Fly  1116 VQSYSVWLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKF 1180
            |...:....|...||..| |..|.:                   |:..|             |:|
Human   716 VPPTATEEQYAGSDPKRP-EMPSKK-------------------PMSRG-------------DRF 747

  Fly  1181 TDTAYSFPIQTDQDNTSLIVAITVP--------------LTII-LVLLVTLLFYKRRRNNCR--- 1227
            ::.:....:...:.|||.:::...|              ||.: |:||:.:|.|.|..|..:
Human   748 SEDSRFITVNPAEKNTSGMISRPAPGRMEWIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKG 812

  Fly  1228 -------------KTTKDSRA--------NDNMSLPDSVIEQNRPIL----------IKNFAEHY 1261
                         :..|.||.        .::.|.|..|..::.||:          :|.|.:|.
Human   813 FPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHI 877

  Fly  1262 RLMSADSDFRFSEEFEELKHVGRDQPCT--FADLPCNRPKNRFTNILPYDHSRFKLQPV--DDDE 1322
            ..:.:::...|||:|||::....|...|  .::.|.|:.|||:.|||.|||||.||:|:  .|.:
Human   878 GELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSK 942

  Fly  1323 GSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPN 1387
            .|||||||||.|:|..:.:|.|||||.||.:|||||.||.|:..|||:|...||||.|||||||.
Human   943 HSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPT 1007

  Fly  1388 DTVPVFYGDIKVQILNDSHYADWVMTEFML--------CRGS-----EQRILRHFHFTTWPDFGV 1439
            :.... ||:|.|.:.:...:|.:.:..|.:        .:|:     .:|::..:|:|.|||.||
Human  1008 ENSEE-YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGV 1071

  Fly  1440 PNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMR 1504
            |.....::.|||........|..|::|||||||||:||:|.:|.:||||.....|::.|.:..:|
Human  1072 PEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIR 1136

  Fly  1505 KERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGY--------EGQQVQLDENGDVV 1561
            .:|.::||||:|||.||..||..:.|||..|. :.::|   .|        .|.:.:|::...:|
Human  1137 TQRNYLVQTEEQYIFIHDALLEAILGKETEVS-SNQLH---SYVNSILIPGVGGKTRLEKQFKLV 1197

  Fly  1562 ATIEGHLSHHDLQQAEAEAIDDENAAILHDDQ-----QPL----------TSSFTGHHTH----- 1606
            .............|.|.....:.|::::..::     .||          .|...|::..
Human  1198 TQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFII 1262

  Fly  1607 ----MPPTTSMSSFGGGGGGHTNVDAPDRXHSVVNQSDNNNSVVIVLVDNK----------PS-- 1655
                :|.||.                 |....:   .|:|..::::|.||:          ||
Human  1263 TQHPLPHTTK-----------------DFWRMI---WDHNAQIIVMLPDNQSLAEDEFVYWPSRE 1307

  Fly  1656 -SMICK 1660
             ||.|:
Human  1308 ESMNCE 1313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	4/15 (27%)
		fn3	220..304	CDD:278470	17/90 (19%)
		fn3	315..391	CDD:278470	11/84 (13%)
		FN3	405..494	CDD:238020	19/95 (20%)
		FN3	511..574	CDD:238020	12/65 (18%)
		FN3	583..671	CDD:238020	8/87 (9%)
		fn3	683..753	CDD:278470	12/69 (17%)
		fn3	787..850	CDD:278470	10/62 (16%)
		fn3	866..935	CDD:278470	8/69 (12%)
		fn3	961..1043	CDD:278470	14/81 (17%)
		PTPc	1272..1525	CDD:214550	118/269 (44%)
		PTPc	1298..1525	CDD:238006	108/241 (45%)
PTPRG	XP_016862450.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910