DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and PTPRF

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:XP_005271136.1 Gene:PTPRF / 5792 HGNCID:9670 Length:1922 Species:Homo sapiens


Alignment Length:1677 Identity:416/1677 - (24%)
Similarity:653/1677 - (38%) Gaps:441/1677 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 TVTITTA----PDP--------------PSNLSV-QVRSGKNAIILWSPPTQGSYTAFKIKVLGL 161
            |.|:..|    |||              .||..: |:|||...|.......||.|     :.:..
Human   151 TATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKY-----ECVAT 210

  Fly   162 SEASSSYN--RTFQVNDNTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNT----P 220
            :.|.:.|:  ....|.|   |..|:.:.|                       .|:..|::    |
Human   211 NSAGTRYSAPANLYVRD---QREVRRVAP-----------------------RFSIPPSSQEVMP 249

  Fly   221 GKFIVWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGE-PPGPAQAAFKGLVP 284
            |..:    |.|.:.|  ..|.|   |..:.:..|.         :.||.| |.|........:|.
Human   250 GGSV----NLTCVAV--GAPMP---YVKWMMGAEE---------LTKEDEMPVGRNVLELSNVVR 296

  Fly   285 GRAYN-ISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKY-- 346
            ...|. :::.::...|.:...|.  :.:|..|:::....  .|:.|..:.|::  |.||...|  
Human   297 SANYTCVAISSLGMIEATAQVTV--KALPKPPIDLVVTE--TTATSVTLTWDS--GNSEPVTYYG 355

  Fly   347 -------------QVSVATTRRQSTVPRSNEPVAFFDFRDIA-------EPGKTFNVIVKTVSGK 391
                         :|....|.|.|....|  |.:.:.||.:|       .|.:.  |..:|....
Human   356 IQYRAAGTEGPFQEVDGVATTRYSIGGLS--PFSEYAFRVLAVNSIGRGPPSEA--VRARTGEQA 416

  Fly   392 VTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWE--ADPASTQDEYRIVY--------HELET 446
            .:|.|       |.:..|.|      ..:||::.||  .:|......||:.|        :....
Human   417 PSSPP-------RRVQARML------SASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHK 468

  Fly   447 FNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNET-SIFVVTR---PSSP------II 501
            .|.|...||      |:.|||||..|||.|.|.:...:...: :|.|.|:   |:.|      :.
Human   469 HNTDAGLLT------TVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVE 527

  Fly   502 EDLKSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKE--SRLVIKNLQPGAGYELKVF 564
            .|.:     :.:||......:...||::|......|.:.:.|.:  |...:::|:|...|..::.
Human   528 SDTR-----IQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLA 587

  Fly   565 AVS-------------HDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPP----ESGEFT 612
            |.|             ...:|.|.|        ||:.:...::.|.:|.|.|.||    .:|..|
Human   588 ARSDMGVGVFTPTIEARTAQSTPSA--------PPQKVMCVSMGSTTVRVSWVPPPADSRNGVIT 644

  Fly   613 EYSIRYR-TDSEQQWVRLPSVRSTEADITDMTKGEKYT-----IQVNT-VSFGVE-SPVPQEVNT 669
            :||:.|. .|.|.:...:....|.|....|:...||:|     ::.:| |..|.| |||....:.
Human   645 QYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDE 709

  Fly   670 TVPPNPVSNI-IQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVR 733
            .||..|...: ::.::|..:.:.|..|.           ||...|:::...|         :.||
Human   710 DVPSGPPRKVEVEPLNSTAVHVYWKLPV-----------PSKQHGQIRGYQV---------TYVR 754

  Fly   734 VLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANG-----EKEDERDTITLSY 793
            :..||                          ||.:|:|| ||::|..     |.||...||:   
Human   755 LENGE--------------------------PRGLPIIQ-DVMLAEAQWRPEESEDYETTIS--- 789

  Fly   794 TPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGR---LYNITV-------W--- 845
            ..||:::....:..::......|.|.|:       ||.||.||||   :.:.|.       |   
Human   790 GLTPETTYSVTVAAYTTKGDGARSKPKI-------VTTTGAVPGRPTMMISTTAMNTALLQWHPP 847

  Fly   846 -TVSGGVASLPIQ--RQDRLYPEPI---------------------------------------- 867
             .:.|.:....:|  |.|...|..|                                        
Human   848 KELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 912

  Fly   868 -----------TQLHATNITDTEISLRWDLP-KGEYNDFDIAY------LTADNLLAQNMTTRNE 914
                       ..||.|.:|.:...|.||.| ..|.|...|:|      :.:...| ||:||...
Human   913 RTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQEL-QNITTDTR 976

  Fly   915 ITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRV--ERFHPTDVQPSEINFE 977
            .|::.|:|  :.|:.:.||:.|.    :.|.|||.|..:......:|  :.|.......:.:...
Human   977 FTLTGLKP--DTTYDIKVRAWTS----KGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLS 1035

  Fly   978 WSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFG-----VIKNLKPGETYVFKIQAKTA 1037
            |.:|.|..:.|  .|.|.|..            :|.|..|     :|.:|:|...|.|.:..:.:
Human  1036 WEVPDSYKSAV--PFKILYNG------------QSVEVDGHSMRKLIADLQPNTEYSFVLMNRGS 1086

  Fly  1038 IGFGPEREYR-QTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDD 1101
            ...|.:.... :|.|.|.|.:|    :|...|.......:..  .:..|.: .||.:.|:|...|
Human  1087 SAGGLQHLVSIRTAPDLLPHKP----LPASAYIEDGRFDLSM--PHVQDPS-LVRWFYIVVVPID 1144

  Fly  1102 AKNASGLEMPSWLDVQSYSVWLPYQAID-----------------PYYPFE-NRSVEDFTIGTEN 1148
            ....|.| .|.|...:...:....:||:                 ||...: :...|.||:|.:.
Human  1145 RVGGSML-TPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKK 1208

  Fly  1149 CDNHKIGYCNGPLKSGTTYRVKVRAF----TGADKFTDTAYS-------FPIQTDQDNTSLIVAI 1202
              |:: |:.|.||....:|:..|.|.    ....::..:.||       .|.|..::...|.|..
Human  1209 --NYR-GFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTG 1270

  Fly  1203 TVPLTIILVLLV-TLLFYKRRRNNCRKTTKDSRANDNMSLPDSV-------IEQNR--------- 1250
            .|...|:::|:| .:|.:||:|.:    :..|:...::.|.||:       :|..|         
Human  1271 PVLAVILIILIVIAILLFKRKRTH----SPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSS 1331

  Fly  1251 --------------PILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNR 1301
                          ||.|.:.|::...:.|:...:||:|:|.: ..|:......::|..|:||||
Human  1332 VPSCPNTSSMRDHPPIPITDLADNIERLKANDGLKFSQEYESI-DPGQQFTWENSNLEVNKPKNR 1395

  Fly  1302 FTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRA 1366
            :.|::.|||||..|..:|...|||||||||:.|:.....:|.|||||..|..|||||.||..:..
Human  1396 YANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTAT 1460

  Fly  1367 IVMLTRCFEKGREKCDQYWP---NDTVPVFYGDIKVQILNDSHYADWVMTEFMLCR--GSEQRIL 1426
            :||:||..||.|.|||||||   .:|.    |.|:|.:|:....|.:.:..|.|.:  .||:|.|
Human  1461 VVMMTRLEEKSRVKCDQYWPARGTETC----GLIQVTLLDTVELATYTVRTFALHKSGSSEKREL 1521

  Fly  1427 RHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTS 1491
            |.|.|..|||.|||..|..::.|:|..:.....:..|:||||||||||:|.||.:|.:|:::...
Human  1522 RQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHE 1586

  Fly  1492 DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL-AVLEGKENIVGPAREMH 1542
            ..|||:|.|..||.:|.:|||||.||:.||:.|| |...|...:  |||.::
Human  1587 KTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEV--PARNLY 1636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 19/97 (20%)
fn3 220..304 CDD:278470 17/85 (20%)
fn3 315..391 CDD:278470 20/97 (21%)
FN3 405..494 CDD:238020 27/99 (27%)
FN3 511..574 CDD:238020 14/77 (18%)
FN3 583..671 CDD:238020 28/99 (28%)
fn3 683..753 CDD:278470 11/69 (16%)
fn3 787..850 CDD:278470 17/76 (22%)
fn3 866..935 CDD:278470 24/126 (19%)
fn3 961..1043 CDD:278470 18/88 (20%)
PTPc 1272..1525 CDD:214550 114/257 (44%)
PTPc 1298..1525 CDD:238006 107/231 (46%)
PTPRFXP_005271136.1 I-set 33..124 CDD:254352
Ig 50..121 CDD:143165
I-set 135..225 CDD:254352 18/78 (23%)
Ig2_RPTP_IIa_LAR_like 152..226 CDD:143215 17/78 (22%)
IG_like 242..319 CDD:214653 18/94 (19%)
Ig3_RPTP_IIa_LAR_like 250..318 CDD:143216 16/85 (19%)
FN3 323..412 CDD:238020 20/96 (21%)
FN3 419..511 CDD:238020 30/110 (27%)
FN3 516..605 CDD:238020 16/93 (17%)
fn3 613..700 CDD:278470 24/86 (28%)
FN3 714..820 CDD:238020 31/162 (19%)
FN3 825..914 CDD:238020 11/88 (13%)
FN3 923..1011 CDD:238020 29/94 (31%)
FN3 1020..>1079 CDD:238020 15/72 (21%)
PTPc 1366..1621 CDD:214550 115/259 (44%)
PTPc 1392..1621 CDD:238006 108/232 (47%)
PTPc 1657..1912 CDD:214550
PTPc 1682..1912 CDD:238006
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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