DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and PTPRC

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_002829.3	Gene:	PTPRC / 5788	HGNCID:	9666	Length:	1306	Species:	Homo sapiens

Alignment Length:	1535	Identity:	318/1535 - (20%)
Similarity:	535/1535 - (34%)	Gaps:	482/1535 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   548 LVIKNLQPGAGY-ELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVH---WSPPES 608
            |.:|.|..|..: :.:||.........|.....|..|:.|       :.|:.:..|   :||..:
Human     5 LWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVP-------LSSDPLPTHTTAFSPAST 62

  Fly   609 ----GEFTEYSIRYRTDSEQQWVRLPSVRSTEA-DITDMTKGEKYTIQVNTVSFGVESPVP---- 664
                .:|:|.:.....|:....|...|:.:..| :.|.::     ::|...:....:|..|
Human    63 FERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVS-----SVQTPHLPTHADSQTPSAGT 122

  Fly   665 -------QEVNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSE 722
                   ...|..:.|.|.||.|                            ||.||...|.:...
Human   123 DTQTFSGSAANAKLNPTPGSNAI----------------------------SDVPGERSTASTFP 159

  Fly   723 NKSADDLSTVRVLIGELMPGVQYKFDIQT----TSYGIL--SGITSLYPRTMPLIQSDVVVANGE 781
            ......|:|...|.......:..:....|    ||...|  |..|:|.|....:|.:..:.....
Human   160 TDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPS 224

  Fly   782 K---EDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNIT 843
            |   :::...||:.|....::       :.......:.:..:..|:|        .....::|:|
Human   225 KPTCDEKYANITVDYLYNKET-------KLFTAKLNVNENVECGNNT--------CTNNEVHNLT 274

  Fly   844 VWTVSGGVASLPIQRQDRLYPEPIT-----------QLH-ATNI--TDTEISLRWDLPKGEYNDF 894
                ....||:.|.......|:...           ||| .|.:  .||.|.|:|.
Human   275 ----ECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWK--------- 326

  Fly   895 DIAYLTADNLLAQNMTTR----------NEITISDLRPHRNYTFTVVVRSGTESSVLRSS---SP 946
            :|...|.|   .||:|.|          .||.:.:|.|...|.        .:|.:|.::   :.
Human   327 NIETFTCD---TQNITYRFQCGNMIFDNKEIKLENLEPEHEYK--------CDSEILYNNHKFTN 380

  Fly   947 LSASFTTNEAVPG-------RVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAY-----TNI 999
            .|....|:...||       |.|..|...:       .|:.|...    ...|::.|     .:.
Human   381 ASKIIKTDFGSPGEPQIIFCRSEAAHQGVI-------TWNPPQRS----FHNFTLCYIKETEKDC 434

  Fly  1000 NNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVP 1064
            .|| |..:..::       ::||||...||..:.|                           .:.
Human   435 LNL-DKNLIKYD-------LQNLKPYTKYVLSLHA---------------------------YII 464

  Fly  1065 TEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDA--------KNASGLEMPSWLDVQSYSV 1121
            .:|.|:.|.....|...  |....||...|:.:..|::        ::.:|......|:|::.:.
Human   465 AKVQRNGSAAMCHFTTK--SAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNT 527

  Fly  1122 WLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTG---ADKFT-- 1181
            .:           .|.|       .:|||     :....|:..|.|..|.....|   .:.|.
Human   528 LV-----------RNES-------HKNCD-----FRVKDLQYSTDYTFKAYFHNGDYPGEPFILH 569

  Fly  1182 -DTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTLLFYK----RRRNNCRKTTKDSRANDNMSL 1241
             .|:|         |:..::|....|.|:..:.:.::.||    .::.:|           |:..
Human   570 HSTSY---------NSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSC-----------NLDE 614

  Fly  1242 PDSVIEQN--------RPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRP 1298
            ...::|::        .||......|.|:...||....|..||:.:..|....|...|..|.|:.
Human   615 QQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQN 679

  Fly  1299 KNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESN 1363
            |||:.:|||||::|.:|..::.|.||:||||:|:.|...||::|..|||...|.||||||.||..
Human   680 KNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQK 744

  Fly  1364 SRAIVMLTRCFEKGREKCDQYWPN-DTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQ---R 1424
            :..|||:|||.|..|.||.:|||: :.....:||:.|:|.......|:::.:..:....|:   |
Human   745 ATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGR 809

  Fly  1425 ILRHFHFTTWPDFGVPNPPQTLV---RFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQ 1486
            .:.|..||:|||.|||..|..|:   |.|.||.:....   ||||||||||||:||:|.:|.:|:
Human   810 EVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSG---PIVVHCSAGVGRTGTYIGIDAMLE 871

  Fly  1487 QINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQ 1551
            .:...:.||::|.|..:|::|..|||.|.|||.|||.|
Human   872 GLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL--------------------------- 909

  Fly  1552 VQLDENGDVVATI-EGHLSHHDLQQAEAEAIDDENAAILHDDQQPLTSSFTGHHTHMPPTTSMSS 1615
            |:.::.|:....: |.|...|::::.:..:           :..||.:.|    ..:|...|.
Human   910 VEYNQFGETEVNLSELHPYLHNMKKRDPPS-----------EPSPLEAEF----QRLPSYRSW-- 957

  Fly  1616 FGGGGGGHTNVDAPDRXHSVVNQSDNNNSVVIVLVDNKPSSMICKDSKGGNIDVLESQQQQQQQQ 1680
                           |...:.||.:|.:.       |:.|::|..|
Human   958 ---------------RTQHIGNQEENKSK-------NRNSNVIPYD------------------- 981

  Fly  1681 QQQPNQGGHNITTISAINGYN--TLQHR----RKSQLITFSSSSCDIKNSLSHEYINGSNGSAAN 1739
                               ||  .|:|.    ::|:..:..||..|..:....:|||
Human   982 -------------------YNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYIN-------- 1019

  Fly  1740 GPPSSGSGSGSGPGSNRASRANVRLSFAEEDVMILPQNHSQQS-NHQDDEVFTRRRSLL------ 1797
                                |:..:|:.:.:|||..|...::: ......:|.|:..::
Human  1020 --------------------ASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTEL 1064

  Fly  1798 ---EVEIGVEVGEDGELAPHEMEEDLEEEDEDE-------EL-------------YMHDEFETH- 1838
               :.||..:...:|:....::|.||::.|:..       ||             |.:..:...
Human  1065 KHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQ 1129

  Fly  1839 --------------IDTKSNNANDDSGGGSYEDSHALHSSLGGSNR--------NSLEKDDDDIE 1881
                          :..|....|...|...::.:..|.....||.:        |.||..:.:..
Human  1130 LPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEV 1194

  Fly  1882 VDVIST----------DVSCYDQ------LLGSSCNTRNG 1905
            ||:...          .||.::|      ::.|:...:||
Human  1195 VDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNG 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020	6/26 (23%)
		FN3	583..671	CDD:238020	17/106 (16%)
		fn3	683..753	CDD:278470	9/73 (12%)
		fn3	787..850	CDD:278470	7/62 (11%)
		fn3	866..935	CDD:278470	21/92 (23%)
		fn3	961..1043	CDD:278470	16/86 (19%)
		PTPc	1272..1525	CDD:214550	110/259 (42%)
		PTPc	1298..1525	CDD:238006	102/233 (44%)
PTPRC	NP_002829.3	PTP_N	7..32	CDD:372119	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..163		29/174 (17%)
		PHA03255	81..>231	CDD:165513	31/182 (17%)
		CD45	237..295	CDD:372194	9/76 (12%)
		FN3	392..462	CDD:238020	19/115 (17%)
		FN3	485..565	CDD:238020	17/102 (17%)
		R-PTPc-C-1	707..907	CDD:350405	87/202 (43%)
		Substrate binding. /evidence=ECO:0000250	853..859		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	993..1014		4/20 (20%)
		R-PTP-C-2	1017..1223	CDD:350406	35/233 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1261..1306
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910