DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and PTPRB

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:XP_006719591.1 Gene:PTPRB / 5787 HGNCID:9665 Length:2230 Species:Homo sapiens


Alignment Length:1883 Identity:526/1883 - (27%)
Similarity:793/1883 - (42%) Gaps:465/1883 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 LYQLSKATTRIRLKRQKAVPQHRWLWSLAFLAAFTLKDVRCADLAISIPNNPGLDDGA--SYRLD 64
            ||.|:..|....|:      .:||            |.||.|.:.:|  |....:||:  |.::.
Human   483 LYNLTVMTEAAGLQ------NYRW------------KLVRTAPMEVS--NLKVTNDGSLTSLKVK 527

  Fly    65 YS-PPFGYPEPNTTIA-------SREIG---DEIQFSRALPGTKYNFWLYYTNFTHHDWLTWTVT 118
            :. ||......|.|::       ||.:.   .|..|...:||..|.                 ||
Human   528 WQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQ-----------------VT 575

  Fly   119 IT---------------TAPDPPSNLSVQVRSG--KNAIILWSPPTQGSYTAFKIKVLG----LS 162
            ::               |.||..:||... .:|  ::.::.||||. |.:..::|.:..    |.
Human   576 VSCVSGELSAQKMAVGRTFPDKVANLEAN-NNGRMRSLVVSWSPPA-GDWEQYRILLFNDSVVLL 638

  Fly   163 EASSSYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFI--- 224
            ..:.....|..|.|:|      .|.||..|:|:          |...|.|........|:.:   
Human   639 NITVGKEETQYVMDDT------GLVPGRQYEVE----------VIVESGNLKNSERCQGRTVPLA 687

  Fly   225 -----VWFRNETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVP 284
                 |...|||:|.::||.  |...:..|.:|:    |:..:|.:.|...... .:..|..|||
Human   688 VLQLRVKHANETSLSIMWQT--PVAEWEKYIISL----ADRDLLLIHKSLSKDA-KEFTFTDLVP 745

  Fly   285 GRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVS 349
            ||.|..:|.::|.| :...::.:.||||.:..::......:||:.| ..|...:|..||  |||.
Human   746 GRKYMATVTSISGD-LKNSSSVKGRTVPAQVTDLHVANQGMTSSLF-TNWTQAQGDVEF--YQVL 806

  Fly   350 VATTRRQSTVPRSNEPVAF----FDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRN 410
            :.    ...|...||.::.    :.|..: :.|..::|:|.||||.::|.....:....|..|..
Human   807 LI----HENVVIKNESISSETSRYSFHSL-KSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSG 866

  Fly   411 LRSINDDKTNTMIITWEADPASTQDEYRIVYHELETFNGD------------------------- 450
            :...|..:.:.:.::|...|... |.|.:      |.:.|                         
Human   867 VTVNNSGRNDYLSVSWLLAPGDV-DNYEV------TLSHDGKVVQSLVIAKSVRECSFSSLTPGR 924

  Fly   451 --TSTLTT---------------------------------------------DRTRFTLES--- 465
              |.|:||                                             |....|:::   
Human   925 LYTVTITTRSGKYENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNN 989

  Fly   466 ------------------LLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSPIIEDLKSIRM--- 509
                              |:|||.||::|...|.:.|:||..      ....|.|.:|.:.:   
Human   990 FIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSGQYEANEQG------NGRTIPEPVKDLTLRNR 1048

  Fly   510 ---GLNISWKSDVNSKQEQYEVLYSRNGTSDLR-------TQKTKESRLVIKNLQPGAGYELKVF 564
               .|:::| |..|...:|||:....|   |::       .....|.|..  :|.||..|::.|.
Human  1049 STEDLHVTW-SGANGDVDQYEIQLLFN---DMKVFPPFHLVNTATEYRFT--SLTPGRQYKILVL 1107

  Fly   565 AVSHDLRSEPHAYFQA-VYPNPPRNMTIE-TVRSNSVLVHWSPPESGEFTEYSI-----RYRTDS 622
            .:|.|::..  |:.:. ..|:..:|:.|. ...::|:.|:|: |..|:...|::     ..:.||
Human  1108 TISGDVQQS--AFIEGFTVPSAVKNIHISPNGATDSLTVNWT-PGGGDVDSYTVSAFRHSQKVDS 1169

  Fly   623 ------------------EQQWVRLPSV------------------------------------- 632
                              ||..:.:.||                                     
Human  1170 QTIPKHVFEHTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSW 1234

  Fly   633 ----------------------RSTEADIT-------DMTKGEKYTIQVNTVSFGVESPVPQEVN 668
                                  |:|....|       |:|.|:||.||:.|||.|:.|...|...
Human  1235 QKAAGVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTEG 1299

  Fly   669 TTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVR 733
            .|||.......|....:|:::..|...||.:..|.:..:..|.       |:.|....|.| ...
Human  1300 RTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDG-------NLQERAQVDPL-VQS 1356

  Fly   734 VLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQ 798
            .....|:.|..||..|.|.| |.||..:.::.||:|   :.|....|...:..|::..:::|   
Human  1357 FSFQNLLQGRMYKMVIVTHS-GELSNESFIFGRTVP---ASVSHLRGSNRNTTDSLWFNWSP--- 1414

  Fly   799 SSSKFDIYRFSLGDAEIRDKEKLANDTDRKVT---FTGLVPGRLYNITVWTVSGGVASLPIQRQD 860
            :|..||.|...|.:.....||   |..|:.:|   |.||||||.|.:.|.|.||.::: .:..:.
Human  1415 ASGDFDFYELILYNPNGTKKE---NWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSN-KVTAES 1475

  Fly   861 RLYPEPITQLHATNITDTEISLRWDLPKG--EYNDFDIAYLTADNLLA----QNMTTRNEITISD 919
            |..|.|.:.:...:|.:|.:::.|..|..  :||||::.:|..|.|..    .|..:...| :..
Human  1476 RTAPSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRI-VYG 1539

  Fly   920 LRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSE 984
            |||.|:|.|.|...||  .|....|.|:..|..|.   |.:::..|......:.|...|..|.|:
Human  1540 LRPGRSYQFNVKTVSG--DSWKTYSKPIFGSVRTK---PDKIQNLHCRPQNSTAIACSWIPPDSD 1599

  Fly   985 ANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQT 1049
            .:|    :||....::.......:..|.|::...|..|.|.:.|:..|:.::| |...|.....|
Human  1600 FDG----YSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSA-GMTSEVVEDST 1659

  Fly  1050 MPIL---APPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAE----DDAKNASG 1107
            :.::   .||.|..:|...:|..|.|:|......::|||.||.|:.:|::|.|    |:.|....
Human  1660 ITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDELKPEQQ 1724

  Fly  1108 LEMPSWLDVQSYSVWLPYQAIDPYY-------PFENRSVEDFTIGTE------NCDNHKIGYCNG 1159
            ..:||:|:.:..:....||.  .|:       |..|....:..:|.|      .||..:..:|:|
Human  1725 HPLPSYLEYRHNASIRVYQT--NYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDG 1787

  Fly  1160 PLKSGTTYRVKVRAFT-----GADKFT-----DTAYSFPIQTDQDNT-SLIVAITVPLTII--LV 1211
            |||..|.||:.:||||     ...:||     ||.:|.||.|:.:.. ..|..::..|.:|  ||
Human  1788 PLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLV 1852

  Fly  1212 LLVTLLFYKRRRNNCRKTTKDSRANDNMSL------PDSV-----IEQNR----PILIKNFAEHY 1261
            .:|.||.       ||:.....|...:..|      |.||     .:.||    ||.|..|..|:
Human  1853 AVVALLI-------CRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHF 1910

  Fly  1262 RLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDY 1326
            ..:.|||::..|:|:||||.|||:|.|..|.||.||.|||:.||||||.:|.||..||||..|||
Human  1911 MKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDY 1975

  Fly  1327 INANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVP 1391
            |||:|:||:|..||:|||||||..|:||||:|.||.|...|||:|:|.||||.|||.|||.|...
Human  1976 INASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDS 2040

  Fly  1392 VFYGDIKVQILNDSHYADWVMTEFMLCRGSEQ----RILRHFHFTTWPDFGVPNPPQTLVRFVRA 1452
            ::|||:.:|:|::|...:|.:.||.:| |.||    |::||||:|.|||.|||...|:|::|||.
Human  2041 LYYGDLILQMLSESVLPEWTIREFKIC-GEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRT 2104

  Fly  1453 FRDRI----GAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQT 1513
            .||.|    ||  .|.||||||||||:||||.|||||||:::.|.|||:|.|:.:|..||.||||
Human  2105 VRDYINRSPGA--GPTVVHCSAGVGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQT 2167

  Fly  1514 EQQYICIHQCLLAVLEGK------ENIVGPAREMHDNEGYEGQQVQLDENGDVVATIEGHLSH 1570
            |.||:.:|||:..||..:      ||.:.|..|..:.|.:.|                |||.|
Human  2168 ECQYVYLHQCVRDVLRARKLRSEQENPLFPIYENVNPEYHRG----------------GHLLH 2214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 20/86 (23%)
fn3 220..304 CDD:278470 24/91 (26%)
fn3 315..391 CDD:278470 20/79 (25%)
FN3 405..494 CDD:238020 26/181 (14%)
FN3 511..574 CDD:238020 18/69 (26%)
FN3 583..671 CDD:238020 31/177 (18%)
fn3 683..753 CDD:278470 16/69 (23%)
fn3 787..850 CDD:278470 23/65 (35%)
fn3 866..935 CDD:278470 21/74 (28%)
fn3 961..1043 CDD:278470 17/81 (21%)
PTPc 1272..1525 CDD:214550 152/260 (58%)
PTPc 1298..1525 CDD:238006 136/234 (58%)
PTPRBXP_006719591.1 RICIN <22..94 CDD:238092
fn3 255..319 CDD:278470
fn3 331..407 CDD:278470
fn3 422..488 CDD:278470 3/4 (75%)
FN3 507..582 CDD:238020 18/93 (19%)
fn3 596..672 CDD:278470 22/93 (24%)
fn3 687..765 CDD:278470 23/85 (27%)
fn3 774..847 CDD:278470 20/80 (25%)
fn3 862..938 CDD:278470 12/82 (15%)
fn3 950..1026 CDD:278470 10/75 (13%)
fn3 1039..1112 CDD:278470 18/78 (23%)
fn3 1126..1199 CDD:278470 14/73 (19%)
fn3 1216..1294 CDD:278470 15/77 (19%)
fn3 1305..1378 CDD:278470 18/81 (22%)
fn3 1394..1466 CDD:278470 25/77 (32%)
fn3 1480..1562 CDD:278470 24/84 (29%)
fn3 1574..1649 CDD:278470 16/79 (20%)
PTPc 1920..2178 CDD:214550 151/260 (58%)
PTPc 1947..2178 CDD:238006 135/233 (58%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 285 1.000 Domainoid score I1621
eggNOG 1 0.900 - - E2759_KOG0791
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2125
Inparanoid 1 1.050 556 1.000 Inparanoid score I1112
Isobase 1 0.950 - 0 Normalized mean entropy S5167
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D16347at33208
OrthoFinder 1 1.000 - - FOG0001181
OrthoInspector 1 1.000 - - otm40832
orthoMCL 1 0.900 - - OOG6_106915
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 1 1.000 - - X4185
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.710

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