DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and PTPN14

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_005392.2	Gene:	PTPN14 / 5784	HGNCID:	9647	Length:	1187	Species:	Homo sapiens

Alignment Length:	1162	Identity:	250/1162 - (21%)
Similarity:	418/1162 - (35%)	Gaps:	361/1162 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   519 VNSKQEQYEVLYSRNGTSDLRTQKT---------KESRLVIKNLQPGAGYELKVFAVSHDLRSEP 574
            |.::..:..|:|..|...::...|:         :|:.|...:....|.|..::||..|...
Human   241 VRNRIGRQAVIYRWNDMGNITHNKSTILVELINKEETALFHTDDIENAKYISRLFATRHKFY--- 302

  Fly   575 HAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADI 639
                        :...|.|.:||      |||.......:| |.....:|.:: ||.|.
Human   303 ------------KQNKICTEQSN------SPPPIRRQPTWS-RSSLPRQQPYI-LPPVH------ 341

  Fly   640 TDMTKGEKYT---IQVNTVSFGVESPV---------PQEVNTTVPPNPVSNIIQLVDSRNITLEW 692
              :..||.|:   ...:::..|.|..:         ...:|.||....|.: :..|:|.|.:
Human   342 --VQCGEHYSETHTSQDSIFHGNEEALYCNSHNSLDLNYLNGTVTNGSVCS-VHSVNSLNCS--- 400

  Fly   693 PKPEGRVESYILKWWPSDNPGRVQTKNVSENKS--------ADDLSTVR---VLIGELMPGVQYK 746
                   :|:|            |...||.|.|        ||.:.:.|   :::....|...|:
Human   401 -------QSFI------------QASPVSSNLSIPGSDIMRADYIPSHRHSAIIVPSYRPTPDYE 446

  Fly   747 FDIQTTSYGIL---SGITSLYPRTMPLIQS-------DVVVANGEKEDERDTITLSYTPTPQSSS 801
            ..::....|||   |...||  |.:.:|.:       |:|.:..|.. ||...|:.|.|.
Human   447 TVMRQMKRGILHTDSQSQSL--RNLNIINTHAYNQPEDLVYSQPEMR-ERHPYTVPYGPQ----- 503

  Fly   802 KFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGR----LYNITVWTVSGGVASLPIQRQDRL 862
              .:|           ..||.:.:|::.....:||.:    ..:.||.|..  :|::.:|
Human   504 --GVY-----------SNKLVSPSDQRNPKNNVVPSKPGASAISHTVSTPE--LANMQLQ----- 548

  Fly   863 YPEPITQLHATNITDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNM--------TTRNEITISD 919
                                      |.:|     |.|| ::|...:        ..|...:..|
Human   549 --------------------------GSHN-----YSTA-HMLKNYLFRPPPPYPRPRPATSTPD 581

  Fly   920 LRPHRN-YTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSS 983
            |..||: |.      ||:...::.....||......::.|    ..|.:..:.||     .|.::
Human   582 LASHRHKYV------SGSSPDLVTRKVQLSVKTFQEDSSP----VVHQSLQEVSE-----PLTAT 631

  Fly   984 EANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQ 1048
            :.:|.:.:                     ..:..|:.::..|      ::|.|..........|.
Human   632 KHHGTVNK---------------------RHSLEVMNSMVRG------MEAMTLKSLHLPMARRN 669

  Fly  1049 TMPILAPPRPAT---QVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIV----AEDDAKNA- 1105
            |:....||...:   :|.....|....|         |||.       |:::    :|::.:.|
Human   670 TLREQGPPEEGSGSHEVPQLPQYHHKKT---------FSDA-------TMLIHSSESEEEEEEAP 718

  Fly  1106 -SGLEMPSWLDVQSYSVWLPYQAI--------DPYYPFENRSVEDFTIGTENCD----------- 1150
             |..::|...:...||..|  ||.        .|.||...:||.:..:..:...
Human   719 ESVPQIPMLREKMEYSAQL--QAALARIPNKPPPEYPGPRKSVSNGALRQDQASLPPAMARARVL 781

  Fly  1151 NHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAITVP-LTIILVLLV 1214
            .|      ||.|:.:..|....|..||                   ||..:|:.| ||.:
Human   782 RH------GPAKAISMSRTDPPAVNGA-------------------SLGPSISEPDLTSV----- 816

  Fly  1215 TLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIKNF---------AEHYRLMSA---- 1266
                 |.|..  ::..|:...::..||.||:||  |.::|:|.         |:...||.|
Human   817 -----KERVK--KEPVKERPVSEMFSLEDSIIE--REMMIRNLEKQKMAGLEAQKRPLMLAALNG 872

  Fly  1267 ---------------------DSDFRFSE----------EFEELKHVGRDQPCTFADLPCNRPKN 1300
                                 |..||..:          |:|::.....:...:.|.||.|..::
Human   873 LSVARVSGREENRVDATRVPMDERFRTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERS 937

  Fly  1301 RFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPRE--FIVTQGPLHSTRDDFWRMCWESN 1363
            |...::||:.:|.:|.|..:: .:.||||:::.......|  :|.|||||..|..|||:|.||..
Human   938 RIREVVPYEENRVELIPTKEN-NTGYINASHIKVVVGGAEWHYIATQGPLPHTCHDFWQMVWEQG 1001

  Fly  1364 SRAIVMLTRCFEKGREKCDQYWP---NDTVPVFYGDIKV--QILNDS-HYADWVMTEFMLCRGSE 1422
            ...|.|:|...|.||.|..:|||   :......||..||  :...|| .||...:....|..|.|
Human  1002 VNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSVCYATTGLKVKHLLSGQE 1066

  Fly  1423 QRILRHFHFTTWPDFGVPNPPQTLVRF------VRAFRDRI--GAEQR--PIVVHCSAGVGRSGT 1477
             |.:.|..:|.|||.|.|...|..:.:      ||...:.:  |.:.|  ||||||||||||:|.
Human  1067 -RTVWHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGV 1130

  Fly  1478 FITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENI 1534
            .|..:.::..:..::.|::..::..:|::|::|:||..||..::|.|:..|:....|
Human  1131 LILSELMIYCLEHNEKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQNSRLI 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020	12/63 (19%)
		FN3	583..671	CDD:238020	19/99 (19%)
		fn3	683..753	CDD:278470	15/80 (19%)
		fn3	787..850	CDD:278470	12/66 (18%)
		fn3	866..935	CDD:278470	12/77 (16%)
		fn3	961..1043	CDD:278470	9/81 (11%)
		PTPc	1272..1525	CDD:214550	87/280 (31%)
		PTPc	1298..1525	CDD:238006	81/244 (33%)
PTPN14	NP_005392.2	B41	24..220	CDD:214604
		FERM_C_PTPN14_PTPN21	215..305	CDD:270009	12/78 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..531		4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..690		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	787..824		13/67 (19%)
		PTPc	935..1179	CDD:238006	82/245 (33%)
		Substrate binding. /evidence=ECO:0000250	1121..1127		5/5 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910