DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and PTPN4

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_002821.1	Gene:	PTPN4 / 5775	HGNCID:	9656	Length:	926	Species:	Homo sapiens

Alignment Length:	1182	Identity:	258/1182 - (21%)
Similarity:	407/1182 - (34%)	Gaps:	368/1182 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 TRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSPIIEDLKSIRMG---LNISWKSDVN 520
            :||.|.:   ||.|::....:::..:..|....::...::.....:.....|   |::.:|....
Human     3 SRFRLPA---GRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDL 64

  Fly   521 SKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNP 585
            ::|:.:.:..:.:.|.:.|.  ...::.:.|.|:.|:.|.|. |.|.          |....||.
Human    65 TEQDYFGLQLADDSTDNPRW--LDPNKPIRKQLKRGSPYSLN-FRVK----------FFVSDPNK 116

  Fly   586 PRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRST---------EADITD 641
            .:.                     |:|.|....:...:....|||...:|         ::::.|
Human   117 LQE---------------------EYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGD 160

  Fly   642 MTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKW 706
            ..:.|..:..::..||     :|.:      |......|..:..::|.|   .|.....:|:
Human   161 YDQSENLSGYLSDYSF-----IPNQ------PQDFEKEIAKLHQQHIGL---SPAEAEFNYL--- 208

  Fly   707 WPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQ-YKFDIQTTSYGILSGITSLYPRTMPL 770
                |..|.......|...|.|.|...::||.:..|:. ||..::..::..|..:...:......
Human   209 ----NTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCKQFF 269

  Fly   771 IQSDVVVANGEKEDERDTI----TLSY--------------------TPTPQSSSKFDIYRFSLG 811
            ||     ...|..:.|:|:    .::|                    .|.|...:.|..| |:||
Human   270 IQ-----LRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHY-FTLG 328

  Fly   812 DAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNIT 876
            .               |..:.|       ...|.:|..|...   ..:||::....::..|..:.
Human   329 S---------------KFRYCG-------RTEVQSVQYGKEK---ANKDRVFARSPSKPLARKLM 368

  Fly   877 DTEISLRWDLPKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVL 941
            |.|:..|        |.     ::.|.|..|::.:|:.....:   |||.|||   :.||.   |
Human   369 DWEVVSR--------NS-----ISDDRLETQSLPSRSPPGTPN---HRNSTFT---QEGTR---L 411

  Fly   942 RSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSS-EANGVIRQFS------------ 993
            |.||           |...|:  |.....|||:......||| :||.::.:.|
Human   412 RPSS-----------VGHLVD--HMVHTSPSEVFVNQRSPSSTQANSIVLESSPSQETPGDGKPP 463

  Fly   994 --------------IAYTNINNLTDAGMQDFES--EEAFG-------------------VIKNLK 1023
                          |.|::       ..||.||  .|.|.                   |:..:|
Human   464 ALPPKQSKKNSWNQIHYSH-------SQQDLESHINETFDIPSSPEKPTPNGGIPHDNLVLIRMK 521

  Fly  1024 PGETYVFKIQAKTAIGFGPEREYRQTMPIL----APPRPATQVVPTEVYRSSSTIQIRFRKNYFS 1084
            |.|...|        ||..:..|.|.||::    ||..||...||              |.|
Human   522 PDENGRF--------GFNVKGGYDQKMPVIVSRVAPGTPADLCVP--------------RLN--- 561

  Fly  1085 DQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTENC 1149
             :..||   .:|...|.|::..                      |....|...|          |
Human   562 -EGDQV---VLINGRDIAEHTH----------------------DQVVLFIKAS----------C 590

  Fly  1150 DNHKIGYCNGPL----KSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIIL 1210
            :.|     :|.|    :....|.|..........|.                     .:|
Human   591 ERH-----SGELMLLVRPNAVYDVVEEKLENEPDFQ---------------------YIP----- 624

  Fly  1211 VLLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPIL----IKNFAEHYRLMSADSDFR 1271
                            .|...||...|:.||.:|:|:....::    :..|.:.||
Human   625 ----------------EKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYR--------- 664

  Fly  1272 FSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANY----V 1332
                    |..|....|  |.||.|..|||:.:|.|||.:|..|:     ...|||||||    :
Human   665 --------KKPGMTMSC--AKLPQNISKNRYRDISPYDATRVILK-----GNEDYINANYINMEI 714

  Fly  1333 PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDI 1397
            |..:...::|..||||..|..|||:|.||..|..:||||...|:||.||.||||..|....||..
Human   715 PSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCY 779

  Fly  1398 KVQILNDSHYADWVMTEFMLC--RGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAE 1460
            :|...::.....::..:..|.  ..:|.|.|....:..|||.|||:.....:.||...|::...:
Human   780 QVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGK 844

  Fly  1461 QRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL 1525
            :.|:|||||||:||:|..||::..:..|..:..|....||..||.:|..|:||..||..:.:.:|
Human   845 EEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAIL 909

  Fly  1526 AVLEGKENIVGP 1537
            .|.|  |..|.|
Human   910 KVYE--EGFVKP 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020	7/34 (21%)
		FN3	511..574	CDD:238020	12/62 (19%)
		FN3	583..671	CDD:238020	14/96 (15%)
		fn3	683..753	CDD:278470	15/70 (21%)
		fn3	787..850	CDD:278470	13/86 (15%)
		fn3	866..935	CDD:278470	15/68 (22%)
		fn3	961..1043	CDD:278470	26/129 (20%)
		PTPc	1272..1525	CDD:214550	92/258 (36%)
		PTPc	1298..1525	CDD:238006	85/232 (37%)
PTPN4	NP_002821.1	B41	30..222	CDD:214604	37/246 (15%)
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010	16/98 (16%)
		FA	325..365	CDD:312314	10/64 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..412		12/40 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	430..475		7/44 (16%)
		PDZ_signaling	515..602	CDD:238492	31/152 (20%)
		PTPc	682..909	CDD:238006	85/231 (37%)
		Substrate binding. /evidence=ECO:0000250	852..858		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910