DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and ptpn20

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:XP_002664234.3 Gene:ptpn20 / 571774 ZFINID:ZDB-GENE-090313-90 Length:2195 Species:Danio rerio


Alignment Length:1748 Identity:350/1748 - (20%)
Similarity:574/1748 - (32%) Gaps:625/1748 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 LAISIPNNPGLDDGASYRLDYSPPFGYPEPNTTIASREIGDEIQFSRALPGTKYNFWLYYTNFTH 109
            :|..||:.|...||                                |..||.:    |...|...
Zfish   808 IASIIPDGPADKDG--------------------------------RIRPGGR----LISLNNIS 836

  Fly   110 HDWLTWTVTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSYTAFKIKVLGL---------SEAS 165
            .:.:|:.:..:...:.|..:.:.|...|..:       :||.|:.....||:         |..|
Zfish   837 LEGVTFNIAASILQNSPEEVELIVSQPKQDL-------RGSKTSLAPSNLGMMLERSFGSQSTLS 894

  Fly   166 SSYNRTFQVNDNTFQHSVKELTP--GATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFR 228
            :.|....:..:.|..:.   :.|  .....:....|.|.::.::.:|..|:.|   ||:.|....
Zfish   895 AEYRPVMEELEETLSNI---MAPKINKRMHIPVVRILDIQDEMSKSSSGFSLK---PGEIIYMEL 953

  Fly   229 NE--------------TTLLVLWQPPYPAGIY--------------------------------- 246
            .:              |.:       :..|||                                 
Zfish   954 RKINGSLGISVAGGINTNV-------HHGGIYIKSVIAGGAADQDGRIQIGDRLLEVDGCNLRAV 1011

  Fly   247 THYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTV 311
            || :.::|.......|:.:..|.|||       ..|....|.:...:..|...:|.|..   |.|
Zfish  1012 TH-RQAVECLKRTGEVVSLVLEREPP-------VVLDTSSASSTLERRRSPSPLSAPLR---RDV 1065

  Fly   312 PLR-PLNV-TFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAFFDFRDI 374
            ||: ||:| |.|..|::..:.                        .:.|:.:|...:.|......
Zfish  1066 PLQTPLSVRTKDFRFVSDENI------------------------LEVTLQKSFSGLGFSFLVSE 1106

  Fly   375 AEPGKTFNVIVKTVSGKVTSWPA-------TGDVTL--RPLPVRNLRSINDDKTNTMIITWEADP 430
            ..|.|...|.:|::|   :..||       .||:.|  ...|||.|      ....::...:..|
Zfish  1107 LGPEKENIVQIKSLS---SGHPAGDCGLLKEGDIILAVNGEPVRGL------SYEEVLHLLQKSP 1162

  Fly   431 AS--------TQDEYRIVYHELETFNGDTSTLTTDRTRFTLESLLPG---RNYSLSVQAVSKKME 484
            :.        :|||:.    ::|||                  |:|.   |:.||.:||      
Zfish  1163 SEIRLSICRPSQDEHT----DIETF------------------LVPNRELRSRSLDLQA------ 1199

  Fly   485 SNETSIFVVTRPSSPIIEDL---KSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKES 546
                      |..:|...:|   ::|.|||.                       .:...::|:||
Zfish  1200 ----------RSVAPDFSELLLRRAIEMGLK-----------------------KEASPEETQES 1231

  Fly   547 RLV--IKNLQP--------GAGYELKVFAVSHDLRSEPHAYFQAVY--------PNPPRNMTI-E 592
            .|:  .|::.|        ..|.|.|           ||......|        |.||....| :
Zfish  1232 ELLETDKSIPPPLPPRPSSAEGGERK-----------PHVILVEEYEKKDPPPPPTPPPTPGILK 1285

  Fly   593 TVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSV-RSTEAD-ITDMTKGEKYTIQVNTV 655
            ...:|:|....:|           :....:.||....|:| ||.... .|...|.|  .::.|.:
Zfish  1286 ASTTNTVQTPAAP-----------KTAIKAHQQESLEPTVSRSNHVSACTSHVKDE--GVEENVI 1337

  Fly   656 SF---GVESPVPQEVNT--TVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRV 715
            ||   |:.....:|..|  |..|:|.|.      |..::.|.|.|.           |:.:|..:
Zfish  1338 SFTANGLTVTAGEEYLTISTTAPSPPSG------STAVSSEAPPPV-----------PALSPSLL 1385

  Fly   716 QTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANG 780
            .|...                        |:..||..|           |...|...|:....:.
Zfish  1386 NTPPT------------------------YQQAIQAAS-----------PAEPPAQPSNNGWDDD 1415

  Fly   781 EKEDERD---------TITLSYTPTPQSSSKFDIYRFSLGDA----EIRDKEKLANDT----DRK 828
            ::||:.|         .:|:|.|.:...|..|.|.|..|.:.    ::.|....|:..    ||.
Zfish  1416 DEEDDEDPRRDVFKEFELTVSLTKSWCGSFGFTITRSKLDNCYYVQDVLDNPAKADGRLRAGDRL 1480

  Fly   829 VTFTGLVPGRLYNITVWTVSGGVASLPIQR--------------QDRLYPEPITQLHATNITDTE 879
            :...|      :|:|  :|:..|| :.|.|              |:.|.|.|...|....|:.| 
Zfish  1481 IMVNG------HNVT--SVTDDVA-ISILRCSSKRLHMVLGRAVQNLLPPPPPDTLQDIIISKT- 1535

  Fly   880 ISLRWDLPKGEYNDFDIAYLTADNLLAQNMT-----TRNEITISDLRPHRNYTFTVVVRSGTESS 939
                   |.|:              |...:|     .|..|.:.::         |:....:|..
Zfish  1536 -------PSGQ--------------LGIKLTGGIGSKRQGIYVQEV---------VLSSPASEEG 1570

  Fly   940 VLRSSSPL-------SASFTTNEAV------PGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQ 991
            .::.:..:       :...|..:||      |.:|......|.||       .:|..:.||:   
Zfish  1571 SIQPNDKIVYICGRCTLGMTLEDAVKVCESSPRKVRFKAMRDDQP-------VIPRDKWNGL--- 1625

  Fly   992 FSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPP 1056
                              ||.:|..|.....:|....|....|...........:|:.:.:.|. 
Zfish  1626 ------------------FEWKEKKGFPHLEEPMSPDVHSALADVKAVADSAMLFRKRLSVTAE- 1671

  Fly  1057 RPATQVVPTEVYRSSSTIQIRFRK--------------------------NYFSDQNGQVRMYTI 1095
                        :.|..:|:.|.|                          ...::|:|::|:..|
Zfish  1672 ------------QESCILQVEFTKPDRGGLGFALVGGVNGSTLRVKDICCGGVAEQDGRLRVGDI 1724

  Fly  1096 IVAEDDAKNASGLEMPSWLDVQSYSVW----------LPYQAID-PYYPFE---NRSVEDFTIGT 1146
            :: |.:....|||.....:|:...:..          ||..|.. ..||.|   |.:..:....|
Zfish  1725 LL-EVNGIIVSGLSHSKVVDILRKAEGTVQLTVCRDILPMSACSASNYPTEAHGNFNTLNSAAQT 1788

  Fly  1147 ENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDN---------------- 1195
            |...:|...:.:.|                             :.:|::                
Zfish  1789 EAHPDHVSFHSDCP-----------------------------ECEQESRNCTPTCQRCCPSLGV 1824

  Fly  1196 TSLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRAN----------------DNMSLPDS 1244
            |.::...|.|             .|:...|....|:.|:::                ...|.|::
Zfish  1825 TDMLQEKTDP-------------QKQHLENSAMKTEHSQSDGWSSDEEEDGDDDDCASQPSPPET 1876

  Fly  1245 VIEQNRPILIKNFAEHYRLMSADSDFRFS--------------------EEFEELKHVGRDQPCT 1289
            :....|||:.:.......::|...:.:::                    :||..|:|:.....|.
Zfish  1877 IPLTGRPIVSEEELSSLAVISPPKNGQYTGSRVKALIQALEQLEKQDLVKEFMALEHLNPSDNCL 1941

  Fly  1290 FADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPRE--FIVTQGPLHSTR 1352
            ....|.||.|||:..|||||.:|.   ||.:|||  ||||:|:.......|  ||..||||..|:
Zfish  1942 VGKAPENREKNRYREILPYDKTRV---PVGEDEG--YINASYIRMKVGSEELFFISAQGPLPGTQ 2001

  Fly  1353 DDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSH----YADWVMT 1413
            |.||:|.||:.|..|.|:||..|:||.||.:||| :.:.|.....:.|:..|::    |....:.
Zfish  2002 DSFWQMVWENRSDVIAMMTREVERGRVKCHKYWP-EKLDVPKETSRYQLFLDNYQMLGYFHIKVI 2065

  Fly  1414 EFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTF 1478
            :.:..:..:...::|..||||||.|.|:....||||:|..| .:.| :.||.||||||:||:|..
Zfish  2066 KMVEKKSGDVHFVKHLKFTTWPDHGTPHSSDQLVRFIRYMR-AVHA-KGPITVHCSAGIGRAGVL 2128

  Fly  1479 ITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVG 1536
            |..|.||..|.....:::..||..||.:|..|:||::||:..::..|.||:....:.|
Zfish  2129 ICTDVILSLIQKDLSINVSDIVKEMRLQRHGMIQTKEQYLFCYKVWLEVLQNISLLYG 2186

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 15/91 (16%)
fn3 220..304 CDD:278470 19/130 (15%)
fn3 315..391 CDD:278470 14/76 (18%)
FN3 405..494 CDD:238020 18/99 (18%)
FN3 511..574 CDD:238020 10/72 (14%)
FN3 583..671 CDD:238020 22/95 (23%)
fn3 683..753 CDD:278470 10/69 (14%)
fn3 787..850 CDD:278470 17/79 (22%)
fn3 866..935 CDD:278470 11/73 (15%)
fn3 961..1043 CDD:278470 14/81 (17%)
PTPc 1272..1525 CDD:214550 100/278 (36%)
PTPc 1298..1525 CDD:238006 92/232 (40%)
ptpn20XP_002664234.3 PKc_like 6..154 CDD:304357
B41 344..546 CDD:214604
FERM_N 347..409 CDD:286467
FERM_M 440..546 CDD:278785
FERM_C_PTPH13 542..643 CDD:270008
PDZ_signaling 776..860 CDD:238492 13/87 (15%)
PDZ 947..1035 CDD:214570 10/95 (11%)
PDZ 1085..1173 CDD:214570 18/120 (15%)
PDZ_signaling 1432..1511 CDD:238492 20/87 (23%)
PDZ_signaling 1527..1608 CDD:238492 16/111 (14%)
PDZ_signaling 1676..1757 CDD:238492 12/81 (15%)
PTPc 1924..2176 CDD:214550 100/259 (39%)
PTPc 1950..2176 CDD:238006 92/233 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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