DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and ptpreb

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_005158846.1	Gene:	ptpreb / 569164	ZFINID:	ZDB-GENE-060503-263	Length:	680	Species:	Danio rerio

Alignment Length:	754	Identity:	200/754 - (26%)
Similarity:	306/754 - (40%)	Gaps:	217/754 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1196 TSLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNR---------- 1250
            |||:      |.|.|:|:..:|.::.:|       ||...:.:..||:..:|...
Zfish    40 TSLL------LVIFLLLVAYILRFREQR-------KDLVTSVDKKLPNGFLEDQEQTVVLLPRSP 91

  Fly  1251 -------PILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTF-------ADLPCNRPKNR 1301
                   ||.:.:..|.:||..||....|.|||..|       ||.|       |....||.|||
Zfish    92 SPSKRYFPIPLDSLEEEFRLRMADDGKLFREEFNSL-------PCGFGCGTFEEASREENREKNR 149

  Fly  1302 FTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRA 1366
            :.|||||||||..|..:|...|||||||:|:.|:....:||..|||...|..|||||.||.....
Zfish   150 YPNILPYDHSRVLLSHIDGYMGSDYINASYIDGYREKNKFIAAQGPKPETVGDFWRMVWEHKCAT 214

  Fly  1367 IVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFML-------CRGSEQR 1424
            |||||...|:..|||.||||.....: ||.::|.:.:.:...|:.:.:|.:       ||  ..|
Zfish   215 IVMLTNTRERKEEKCYQYWPEQGCWI-YGCVRVAMEDFTVLVDYTIRKFCVQHHAAEGCR--PPR 276

  Fly  1425 ILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQIN 1489
            ::...|||:|||||||..|..:::|::..:....|...||:|||||||||:||||.:|.::..::
Zfish   277 LVTQLHFTSWPDFGVPLSPIGMLKFLKKVKSVNPAHAGPIIVHCSAGVGRTGTFIVIDAMMDMMH 341

  Fly  1490 TSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQL 1554
            ....:|:||.|..:||:|..::||:.||..|:|.||                   |.|.....:|
Zfish   342 AEGRLDVFGFVSRIRKQRCQLIQTDMQYSFIYQALL-------------------EHYLFGDTEL 387

  Fly  1555 DENGDVVATIEGHLS--HHDLQQAEAEAIDDE-----NAAILHDDQQPLTSSFTGHHTHMPPTTS 1612
            |     :|::||||.  |:.....:...:::|     |..|:.::.:      ||
Zfish   388 D-----IASLEGHLHKLHNTHTNMDRVGLEEEFRKLTNVRIMKENMR------TG---------- 431

  Fly  1613 MSSFGGGGGGHTNVDAPDRXHSV------------------------VNQS--DNNNSVVIVLVD 1651
                        |:.|..|.:.|                        :|.|  |........:..
Zfish   432 ------------NLPANMRKNRVLQIIPYDFNRVILSMKRGQEFTDYINASFIDGYRQKDYFIAT 484

  Fly  1652 NKPSSMICKDS-------KGGNIDVLESQQQQQQQQ--QQQPNQGGHNITTISAINGYNTLQHRR 1707
            ..|.:...:|.       |..:|.||...::::|::  :..|.:|       |...|...|:.:|
Zfish   485 QAPLAHTVQDFWRMVWEWKCHSIVVLTELKEREQEKCVRYWPAEG-------SVSFGDYVLELKR 542

  Fly  1708 KSQLITFS------SSSCDIKNSLSHEYINGSNGSAANGPPSSGSGSGSGPGSNRASRANVRLSF 1766
            .:...|||      |.:.:.:..|..::  ..:|....|.||.|.|.
Zfish   543 DTLCETFSIRDMLLSYASEKQTRLVRQF--HFHGWPEIGIPSDGKGM------------------ 587

  Fly  1767 AEEDVMILPQNHSQQSNHQDDEV-----------FTRRRSLLEVEIGVEVGEDGEL--------- 1811
              .|::...|...|||.:....|           |....::||     .|..:|.|
Zfish   588 --IDIIAAVQKQQQQSGNNPIVVHCSAGAGRTGTFIALSNILE-----RVKAEGLLDVFQTVKSL 645

  Fly  1812 ---APHEMEEDLEEEDEDEELYMHDEFETHIDTKSNNAN 1847
               .|| |.:.:|:.|     :.:...:..:|..|:.||
Zfish   646 RTQRPH-MVQTVEQYD-----FCYRVVQDFVDIYSDYAN 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	110/266 (41%)
		PTPc	1298..1525	CDD:238006	99/233 (42%)
ptpreb	XP_005158846.1	PTPc	119..378	CDD:214550	112/287 (39%)
		PTPc	146..378	CDD:238006	101/253 (40%)
		PTPc	410..668	CDD:214550	53/325 (16%)
		PTPc	439..668	CDD:238006	45/268 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910