DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and ush2a

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:XP_009291422.1 Gene:ush2a / 568982 ZFINID:ZDB-GENE-060503-794 Length:5243 Species:Danio rerio


Alignment Length:1789 Identity:341/1789 - (19%)
Similarity:548/1789 - (30%) Gaps:730/1789 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 WSLAFLAAFTLKDVRCADLAISIPNNPGLDDG-----------ASYRLDYSPPFGYPEPNT---- 76
            :|:...|..:|..|..:.:::|:|  ||..||           .|.::.::.|..:..|..    
Zfish  2423 YSVMVKACNSLGCVESSPVSVSLP--PGAPDGLLAPRLAAATPTSLQVSWAAPARHNAPGALRYR 2485

  Fly    77 ----TIASREI----GDE-IQFSRAL----PGTKYNFWLYYTNFTHHDWLTWTVTITT-----AP 123
                :.||.::    .|| ..||..:    |.|:|:|.|..:|........|....|.     |.
Zfish  2486 LQMRSSASTQLHQLMDDETTTFSHTVTDLEPFTEYHFRLLVSNSYGETSSPWVSLFTAQDRPGAV 2550

  Fly   124 DPPSNLSVQVRSGKNAIILWSPPTQ--GSYTAFKIKVLGLSEASSSYNR--TFQVNDNTFQHSVK 184
            |||....:|.||   |.|.||||:|  |..|.:.|          ..||  |..|.:|:..|.:.
Zfish  2551 DPPVLSDIQSRS---AFISWSPPSQPNGIITHYNI----------YQNRQLTTSVPENSTSHMLS 2602

  Fly   185 ELTP--------------GATYQVQAYTI------------------------------------ 199
            .|||              |.|...:::||                                    
Zfish  2603 HLTPFQQYTIQVEACTAAGCTLSAESHTINTPPAPPEDVPAPQLYSDTPTSVLLSWAAPRLVNGE 2667

  Fly   200 ---YDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTL---------LV-----------LWQ--- 238
               |..:..|:.|....|.....|.:.:.:..:..||         :|           :|:   
Zfish  2668 LDGYTVERRVSGTQEISTVATIQPNQTLTYLDSSATLSPWSSYEYRIVAHTRLGGSNSSVWEKVT 2732

  Fly   239 --PPYPAGIYTHYKVSIEPPDA------------------NDSV-LYVEKEGEPPGP------AQ 276
              |..|||        ::|||.                  |..: .|..:..||..|      ..
Zfish  2733 TRPSRPAG--------MQPPDGVVLGPESVQVTWAAPLIPNGEIERYEIRMPEPRIPHTNMSLLT 2789

  Fly   277 AAFKGLVPGRAYNISVQTMSED-------EISLPT-TAQYRTVP--LRPLNVTFDRDFITSNSFR 331
            ....||:|...|:|::...|..       ..|||| .....|:|  |.||:|.    .|:.:...
Zfish  2790 HTVSGLMPYTGYSITILACSGGGGHVGGCTESLPTLVTTLPTIPQGLSPLSVV----AISESFLA 2850

  Fly   332 VLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWP 396
            |.|:.|   |..:...:.....||     ::.:|:|       :.|.:.||:.....:|      
Zfish  2851 VSWQLP---SRPNGPNIRFELLRR-----KTQQPLA-------SRPPEDFNLWYNVYAG------ 2894

  Fly   397 ATGDVTLRPLPVRNLRSINDDKTNTMIITWEADPASTQDEYRIVYH-ELETFNGDTSTLTTDRTR 460
                          .:..::|| .....||.        ||:||.| ::.:.:|:.:|..|...:
Zfish  2895 --------------TKLFHEDK-GLSRYTWY--------EYKIVVHNDVGSASGEVATGVTLAGQ 2936

  Fly   461 FTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSPIIEDLKSIRMGLNISWKSDVNSKQEQ 525
                   |.:..::|..|:      |.|:|.|  ..::|.::||:               ...|.
Zfish  2937 -------PLKPTNISAHAL------NHTAILV--NWTTPTLQDLQ---------------GSVEV 2971

  Fly   526 YEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVS---HDLRS----------EPHAY 577
            |.:....:..|...|.....:.:.|.:|||...|:|.: .||   |::.|          ||...
Zfish  2972 YILTVVSDQHSQTLTLDPTVTSVFIPDLQPSTQYKLSL-TVSNGPHNITSPEVNCTTTDGEPEGV 3035

  Fly   578 FQAVYPNPPRNMTIETVRSNSVLVHWSPP--ESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADIT 640
            |      ||.   :.|:.|.:|.|.|:||  .:|...:|||  ..|.     ||......|:...
Zfish  3036 F------PPE---VLTLNSTAVRVMWAPPLLPNGVVVQYSI--YLDG-----RLYGSTGNESGSL 3084

  Fly   641 DMTKGEKYT-----IQVNTVSFGVESPVPQEVNTTVPPNPV---SNIIQLVDSRNITLEWP---K 694
            :|.....||     ::|.||...|:|...|.  |||...|.   :..||::.||::.|||.   :
Zfish  3085 EMGGLLPYTVHSIQVEVCTVYACVKSNSTQV--TTVEDTPAEISTPHIQVLSSRSVKLEWTSPGR 3147

  Fly   695 PEGRVESYILKWW---------------------------PSD---------NP----------- 712
            |.|.:..|.:  |                           |::         ||           
Zfish  3148 PNGILGGYDV--WRRTLKRCEDLQTQQTFAPQSRCSYLECPAEQDFCGKTCYNPEMQICCSGTVH 3210

  Fly   713 GRVQTKNVSENK---SADDLSTV-------------------RVLIGELMPGVQYKFDI--QTTS 753
            ..:|:....|.:   :::|..:|                   .||:.   ||.....|.  |..|
Zfish  3211 NLIQSHQCCEERYIPASEDSGSVCCGGQFVQPLSQHQCCGGYHVLVS---PGEVCCLDSVEQRVS 3272

  Fly   754 YGI----------LSGI-------------------TSLYPRTMPLIQSDVVVANGEKE---DER 786
            .|:          :||:                   ..|.||              |.|   ||.
Zfish  3273 VGLGDSCCAGRPFVSGVGQICCGGRLYDGFKSQCCGGQLVPR--------------ETECCGDEE 3323

  Fly   787 DTITLSY-------------TPT------PQSSSKFDIYRFSLGD-----AEIRDKEK------- 820
            :.|:..:             |.|      |...||..:.......     :|:.|:|:       
Zfish  3324 EGISYEHVSGFSCCGEHYINTSTSWCCTGPGGESKVHVVENRTASLKCCWSEVIDQEEQCCNGVG 3388

  Fly   821 ---LANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISL 882
               |.:....:.....|:|.:....||..||....|.               ....:.:.|:...
Zfish  3389 FNPLTSVCADRAPAGILIPEKCRPSTVCPVSVAAGSF---------------CGLCDFSPTQSIC 3438

  Fly   883 RWDLPKGEYNDFD------------IAYL----TADNLLAQNMTTRNEITISDLRPHRNYT---- 927
            .| :|.|::.:..            :|:.    :::.|:...:..|:..|.::|.|:.:|.    
Zfish  3439 TW-VPSGQFPEHTPSSSAAAEAPSVVAHSQLCPSSEELIYSGVANRHTFTDTELEPYSSYEYRVG 3502

  Fly   928 --------FTVVVRSGTESSVLRSSSP----------------LSASFTTNEAVPGRV------E 962
                    |:|..|..|:..|..|.||                .||....|..:...|      |
Zfish  3503 VWNSFGRGFSVWTRVRTDEDVPYSVSPPNWSHVGLRDDIIQLEWSAPIKPNGEISHYVILRDGQE 3567

  Fly   963 RFHPTD-------------------------------------VQ---------------PSEIN 975
            |:..||                                     ||               |..:.
Zfish  3568 RYRGTDHSFTDAGGIRPFQEYIYQLRACTSAGCTDSTKVVAVTVQGEPEGIGAPVVRALGPGALR 3632

  Fly   976 FEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGV----IKNLKPGETYVFKIQAKT 1036
            ..|. |..:|||||:::.|      |.|..|:....:|   ||    :..|:|...|.|.:.|.|
Zfish  3633 VSWD-PPDKANGVIKEYRI------NQTGVGVIHTHTE---GVMAYNVTGLQPHTNYSFIVMACT 3687

  Fly  1037 AIGFGPER-EYRQTMPILAPPRPA-TQVVPTEVYRSSSTIQIRFRKNYFSDQ---NGQVRMYTII 1096
            |.|.|..: ...|||    ...|| ...:|..:..:||.:::     ::||.   ||.:..|.::
Zfish  3688 AAGCGASQPSMGQTM----EDAPAGVWSMPRHIQLNSSAVEL-----HWSDPLKLNGLLSGYRLL 3743

  Fly  1097 VAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVE-DFTIGTENCDNHKIGYCNGP 1160
                                                    |..| .||     .|..|:.|.:..
Zfish  3744 ----------------------------------------RDGELVFT-----ADGGKMSYTDAG 3763

  Fly  1161 LKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLI-----VAITVPLTIILVLLVTLLFYK 1220
            |:..|.|..::.|.||........|  .|||...:...|     |::..|.::.:......::  
Zfish  3764 LQPNTRYVYELEATTGGGSSRSDRY--VIQTPISSPERIPPPYNVSLHGPRSVFVAWSPPGVY-- 3824

  Fly  1221 RRRNNCRKTTKDSRANDNMSLPDSVIEQN--------RPILIKNFAEHYRLMSADSDFRF----- 1272
                             |:|.|   :|.|        ||::.....|.:.|:.....:..     
Zfish  3825 -----------------NLSFP---LEYNILLNAGTERPLIRSAGLEQFLLLQGLDPYTIYHVQV 3869

  Fly  1273 --------------SEEFEELKHVGRDQPCTFAD---------LPCNRPKNRFTNILPYDHSRFK 1314
                          :....|...:.:|.|.|.|.         .|.::|....||...|      
Zfish  3870 QACQPDGCGVGQGVTVRTPEAAPIAQDPPVTTATGAAVIEVRWSPPHKPNGIITNYFIY------ 3928

  Fly  1315 LQPVDDDEGSDYINANYVPGHNSPREFIVTQGPL 1348
            .:|....|              ....||.|:|||
Zfish  3929 RRPAGTQE--------------ELLVFIWTEGPL 3948

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 30/137 (22%)
fn3 220..304 CDD:278470 25/140 (18%)
fn3 315..391 CDD:278470 15/75 (20%)
FN3 405..494 CDD:238020 19/89 (21%)
FN3 511..574 CDD:238020 14/75 (19%)
FN3 583..671 CDD:238020 27/94 (29%)
fn3 683..753 CDD:278470 22/143 (15%)
fn3 787..850 CDD:278470 16/96 (17%)
fn3 866..935 CDD:278470 14/96 (15%)
fn3 961..1043 CDD:278470 31/143 (22%)
PTPc 1272..1525 CDD:214550 18/105 (17%)
PTPc 1298..1525 CDD:238006 12/51 (24%)
ush2aXP_009291422.1 Laminin_G_3 160..297 CDD:290121
Laminin_N 307..528 CDD:295486
EGF_Lam 529..577 CDD:238012
EGF_Lam 586..638 CDD:238012
Laminin_EGF 653..703 CDD:278482
Laminin_EGF 706..756 CDD:278482
EGF_Lam 759..797 CDD:214543
Laminin_EGF 808..857 CDD:278482
EGF_Lam 859..912 CDD:238012
EGF_Lam 913..963 CDD:238012
EGF_Lam 965..1014 CDD:238012
EGF_Lam 1015..1064 CDD:238012
FN3 1177..1253 CDD:238020
FN3 1264..1375 CDD:238020
FN3 1386..1469 CDD:214495
LamG 1537..1699 CDD:238058
LamG 1737..1890 CDD:238058
FN3 1981..2071 CDD:238020
FN3 2163..2253 CDD:238020
FN3 2258..2341 CDD:238020
FN3 2352..2443 CDD:238020 4/19 (21%)
FN3 2447..2544 CDD:238020 21/96 (22%)
FN3 2547..2633 CDD:238020 30/98 (31%)
FN3 2635..2733 CDD:238020 9/97 (9%)
FN3 2743..2807 CDD:238020 13/63 (21%)
FN3 2830..2932 CDD:238020 30/149 (20%)
fn3 2939..3014 CDD:278470 21/98 (21%)
FN3 3032..>3099 CDD:238020 22/82 (27%)
FN3 3542..3611 CDD:238020 8/68 (12%)
FN3 3615..3701 CDD:238020 24/95 (25%)
fn3 3718..3784 CDD:278470 20/115 (17%)
FN3 3801..3887 CDD:238020 11/107 (10%)
FN3 3908..3971 CDD:238020 13/61 (21%)
FN3 3996..4086 CDD:238020
FN3 4186..4284 CDD:238020
fn3 4288..4366 CDD:278470
FN3 4382..4465 CDD:238020
FN3 4470..4553 CDD:238020
FN3 4555..4653 CDD:238020
FN3 4679..4753 CDD:238020
fn3 4760..4830 CDD:278470
FN3 4864..4955 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 40 1.000 Domainoid score I12524
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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