DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and sdk2a

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_021327143.1	Gene:	sdk2a / 561852	ZFINID:	ZDB-GENE-091008-1	Length:	2224	Species:	Danio rerio

Alignment Length:	1622	Identity:	333/1622 - (20%)
Similarity:	515/1622 - (31%)	Gaps:	501/1622 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 ISIPNNPGLDDGASYRLDYSPPFGYPEPNTTIASREIGDEIQFSRALP------GTKYNFWLYY- 104
            :|:|..|.           |.|     |.|.|||......|......|      |....:.:.|
Zfish   709 VSLPEEPP-----------SAP-----PQTVIASGRTNQSIMIQWQPPPESHQNGPLQGYIIRYC 757

  Fly   105 ------------------TNFTHHDWLTWT-----------------------VTITTAPD-PPS 127
                              ||....|.:.||                       .|:...|. ||.
Zfish   758 LSGLPVDCQMKNITNPDQTNLLLEDLIIWTNYEIEVAAYNGAGQGVYSPKVTEWTLQGVPTVPPG 822

  Fly   128 NLSVQVRSGKNAIILWSPPT----QGSYTAFKIKVLGLSEASSSYNRTFQVNDNTFQHSV----- 183
            |:..:..:.......||.|:    .|....:|:...   |.....:.|.......||.||
Zfish   823 NVQAEAVNSTTVRFTWSAPSPQFINGINQGYKLLAW---EPGHEEDVTLVTVRPNFQDSVHVGYI 884

  Fly   184 ---KELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQ-PPYPAG 244
               |:.|...|..:...|..||..|.|...|.....|...|........:|:|.|.|: ||...|
Zfish   885 SGLKKFTEYFTCVLCFTTPGDGPRSTAQRIRTHEDTPGPVGHLSFTEILDTSLKVSWKDPPEKNG 949

  Fly   245 IYTHYKVSIEPPDANDSVL--YVEKEGEPPGPAQAAFKGLVPGRAYNISVQTM--------SEDE 299
            |.|.|::|.|..:..::.:  |:     |....:....||.....|.|.|..|        |...
Zfish   950 ILTGYRISWEEFNRTNTRVTHYL-----PNMTQEYRVTGLTALTTYTIQVAGMTNKGQGQLSSST 1009

  Fly   300 ISL---------PTTAQYRTVPLRPLNVTFDRDFITSNSF-RVLWEAPKG-ISEFDK----YQVS 349
            ||.         ||......:..|.:.:.|...:....|. |.|.||..| |.|.::    :|:|
Zfish  1010 ISSGVPPEMPGPPTNIAISNISPRSVTLQFKPGYDGKTSISRWLIEAQIGVIGENEEWVMVHQLS 1074

  Fly   350 VATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNVI-----------VKTVSGKVTSWPATGDVTL 403
            .....|...|...| |..::.||     .:..|::           ::|:.......||  ::||
Zfish  1075 NEPDARSLEVQGLN-PYTYYRFR-----MRQVNIVGTSPPSQPSRKIQTLQAPPDIAPA--NITL 1131

  Fly   404 R------------PLPVRNLRSINDDKTNTMIITWEADPASTQDEYRIVYHELETFNGDTSTLTT 456
            |            |||                 .||.:.......||:.|..|.:..|..|.:..
Zfish  1132 RTASETSLWLRWVPLP-----------------EWEYNGNPELVGYRVQYSRLGSKVGFLSHIIP 1179

  Fly   457 DR--TRFTLESLLPGRNYSLSVQAVS-------------KKMES------NETSIFVVTRPSSPI 500
            ||  ..||:|.|.....|.:.|||.:             :..||      ...|.|..|  ||.|
Zfish  1180 DRQEREFTIEDLEEWTEYEVKVQAFNGIGPGPWSQPVHGRTRESVPSSGPANVSAFATT--SSSI 1242

  Fly   501 IEDLKSIRMGLNISW----KSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAG--- 558
            :           :.|    ::|.|.....|:|:|.......:....|.|..........|.|
Zfish  1243 L-----------VRWGDVPETDRNGLILGYKVVYKEKDAESVLHFWTVEGNTTYSVQLTGLGKYV 1296

  Fly   559 -YELKVFA---VSHDLRSEPHAYFQAV--YPNPPRNMTIETVRSNSVLVHWSPP--ESGEFTEYS 615
             ||::|.:   :...:.|.|..:.:.:  .|.||..:....||::||.:.|.||  .:|....|.
Zfish  1297 LYEIQVLSFTRIGDGMPSSPPIFERTLDDVPGPPVGILFPEVRTSSVRLIWQPPAQPNGIILAYQ 1361

  Fly   616 IRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYT-------------IQVNTVSFGVESPVPQEV 667
            |.:|.:|.       |:.|...|:.: ....:||             :...|.....|:.....|
Zfish  1362 IAFRRNSS-------SITSANVDVLN-PSARQYTATGLKPESVYVFRLTAQTRKGWGEAAEALVV 1418

  Fly   668 NT--TVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWP-SDNPGRVQTKNVSENKSADDL 729
            .|  ...|.|.|..:.           |:.|.:..|.:|.|.| ||....::...:...:..|..
Zfish  1419 TTEKRARPQPTSRPVV-----------PQEEVQARSVLLSWEPGSDGLSPIRYYTIQYRELPDSN 1472

  Fly   730 STVR----------VLIGELMPGVQYKFDIQTTS-YGILSGITSLYPRTMPLIQSDVVVANGEKE 783
            .||.          .:|..|.|...|:|.::.|: .|     .|.|..     :|:.:....:..
Zfish  1473 WTVHSASVNHEATSYVIDRLKPFTSYQFRVKATNDIG-----DSEYSE-----ESEAITTLQDAP 1527

  Fly   784 DERDTITLSYT------------PTPQSSSKFDIYRFSLGDAEIR-DK----------------- 818
            |:..|| ||.|            |.|:......:..|.:...|:| |:
Zfish  1528 DKAPTI-LSVTPHTTTSVLVRWKPPPEEEINGILLGFRVRYRELRYDRLRSFTVRTVNSPAGNWA 1591

  Fly   819 EKLANDTDRKVTFTGLVPGRLYN----------ITVWTVSG-GVASLPIQRQDRLYPEPITQLHA 872
            |..|..:.|.::.:.|....|.|          ::|:...| |..|.|   |:....|.:.....
Zfish  1592 ELTAPYSVRNLSESSLTQYELDNLNKHKRYEIRLSVYNAVGEGPTSSP---QEVFVGEAVPTAAP 1653

  Fly   873 TNI-----TDTEISLRWDLP-----KGEYNDFDIAYLTADNLLAQNMTTR--------NEITISD 919
            .|:     |.|::.:.||.|     .|:...:.|.|.   ....||.|.|        ..:.:.:
Zfish  1654 QNVAIQSSTATQLDVTWDPPPVEAQNGDIQGYKIYYW---EFQLQNETERLRTLFLPELSVKLKN 1715

  Fly   920 LRPHRNYTFTV----VVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSL 980
            |..:..|..:|    ....|..|...|.        .|.:|.|......|.:::..:.:|..|..
Zfish  1716 LTGYTTYMISVSAFNAAGDGPRSLPTRG--------RTQQAAPSAPNFIHFSELTTTSVNMSWGE 1772

  Fly   981 PSSEANGVIRQFSIAYTNINNLTD-----AGMQDFESEEAFG------VIKNLKPGETYVFKIQA 1034
            | .:.||::..:.:.|.....:.|     :|:....:.:..|      .||:|..|.||.|:|:|
Zfish  1773 P-KQPNGIVEGYRVVYEPCTPVDDSSPHTSGVSKIVTVDVKGSAPLWMKIKDLADGVTYNFRIRA 1836

  Fly  1035 KTAIGFGPEREYR-QTMPILAPPRPATQVVPTE--VYRSSSTIQIRFRKNYFSDQNGQ-----VR 1091
            || :.:|||.|.. .|.|....|.|     |.|  :.|..|.:.:.:       .||.     :.
Zfish  1837 KT-LTYGPEIEANITTGPGEGAPGP-----PGEPFISRYGSALTLHW-------SNGDPGRAPIT 1888

  Fly  1092 MYTIIVAEDDAKNASGL------EMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTENCD 1150
            .|.|.....|    .||      ::|.  :|.||                          |.|.|
Zfish  1889 RYVIEARPSD----EGLWDILIKDIPK--EVTSY--------------------------TLNLD 1921

  Fly  1151 NHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTS------------LIVAIT 1203
            .         |:.|.||..:|.|      ..|..|..|.......::            |:|...
Zfish  1922 T---------LREGVTYDFRVIA------VNDYGYGSPSAPSPSISAQKVSPFYEEWWFLVVIAL 1971

  Fly  1204 VPLTIILVLLVTLLFYKRRRNNCRKTTK--DSRANDN-MSLPDSVIE--------------QNRP 1251
            |.|..||:|:..|:.    |...:|.||  ||.|:.| .|||.|..|              .||.
Zfish  1972 VGLIFILLLIFILII----RGQSKKYTKKTDSGAHSNCTSLPLSHGEMVRLDEGRFPALELNNRR 2032

  Fly  1252 ILIKN-FAEHYRLMS------ADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYD 1309
            :.:|| |.....:.:      :.....:|:|...:|                     :.:::|.:
Zfish  2033 LSVKNSFCRKNGIYTRSPPRPSPGSLHYSDEDVSIK---------------------YNDLVPAE 2076

  Fly  1310 HSRFKLQP--VDDDEGSDYINANYV--PGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAI 1367
            .|....:|  |.|.:.||   :.|.  |.......|:     .|...|..:...|....:.:
Zfish  2077 SSSLTEKPSEVSDSQASD---SEYELDPNRQKTHSFV-----NHYISDPTYYNSWRRQQKGV 2130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	20/93 (22%)
		fn3	220..304	CDD:278470	24/103 (23%)
		fn3	315..391	CDD:278470	19/92 (21%)
		FN3	405..494	CDD:238020	25/109 (23%)
		FN3	511..574	CDD:238020	14/73 (19%)
		FN3	583..671	CDD:238020	24/104 (23%)
		fn3	683..753	CDD:278470	16/80 (20%)
		fn3	787..850	CDD:278470	19/103 (18%)
		fn3	866..935	CDD:278470	16/90 (18%)
		fn3	961..1043	CDD:278470	22/92 (24%)
		PTPc	1272..1525	CDD:214550	16/100 (16%)
		PTPc	1298..1525	CDD:238006	13/74 (18%)
sdk2a	XP_021327143.1	IGc2	66..124	CDD:197706
		Ig	157..213	CDD:325142
		IGc2	259..313	CDD:197706
		Ig	352..420	CDD:319273
		Ig	442..518	CDD:325142
		I-set	523..612	CDD:333254
		FN3	616..706	CDD:238020
		fn3	719..805	CDD:306538	15/90 (17%)
		FN3	820..916	CDD:238020	22/98 (22%)
		FN3	921..1009	CDD:238020	23/92 (25%)
		FN3	1019..1113	CDD:238020	21/99 (21%)
		FN3	1125..1220	CDD:238020	26/113 (23%)
		fn3	1229..1314	CDD:306538	19/97 (20%)
		FN3	1327..1420	CDD:238020	23/100 (23%)
		FN3	1437..1521	CDD:238020	20/93 (22%)
		FN3	1530..1642	CDD:238020	23/115 (20%)
		FN3	1652..1745	CDD:238020	19/103 (18%)
		FN3	1750..1838	CDD:238020	20/88 (23%)
		FN3	1871..1942	CDD:238020	22/124 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910