DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and ptprk

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_021324239.1	Gene:	ptprk / 555348	ZFINID:	ZDB-GENE-030131-9834	Length:	1500	Species:	Danio rerio

Alignment Length:	1328	Identity:	315/1328 - (23%)
Similarity:	496/1328 - (37%)	Gaps:	407/1328 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   642 MTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPN--PVSNIIQLVDSRNITL----EWPKPEGRVE 700
            |.:.:.:.|..|.:.:..:...|..:|..|..|  |::|.|.     |||.    :|.|.|..|.
Zfish    97 MKENDTHCIDFNYLLYCPDGSSPGTLNVLVKVNKGPLANPIW-----NITACTGKDWMKAELAVS 156

  Fly   701 SYILKWWPSD-------------------------------NP-----GRVQTKNVSENKSADDL 729
            ::    ||::                               :|     |.|:. |..:|.:...:
Zfish   157 TF----WPNEYQVIFEAEVTNGRRGFIAIDDIQVLSYPCDKSPHFLRLGDVEV-NAGQNATFQCI 216

  Fly   730 STVRVLI----------GELMPGVQYK----------FDIQTTS------YGIL------SGITS 762
            :|||..:          ||.:|..:.|          |.::..|      |..:      ||:::
Zfish   217 ATVRDAVNNKLWLQRRNGEDIPVAEKKNINHRKFAASFRLKEVSSQDQDLYRCVTQSERGSGVSN 281

  Fly   763 LY-------PR------------TMPLIQ--SDVVVANGE---KEDERDTITLSYTPT-PQSSSK 802
            ..       ||            |..|||  ::.:..:|.   ||.|....:.|:|.| ..:|..
Zfish   282 FAGLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIFGDGPIILKEVEYRMTSGSWTETHAVNSPN 346

  Fly   803 FDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASL-PIQRQDRLYPEP 866
            :.::.             |..||:.::......||          .||.... |.........||
Zfish   347 YKLWH-------------LDPDTEYEIRVLLTRPG----------EGGTGQPGPALITRTKCAEP 388

  Fly   867 ITQLHATNITDTE---ISLRWDLPKGEYN-----DFDIA----------YLTADNLLAQNMTTRN 913
            :....:..|.:|:   |::.|:  ...||     .|::.          :..||.|.......|:
Zfish   389 MRTPKSLKIAETQARFIAVDWE--SLGYNITRCHTFNVTICYHYHKTPNHSKADCLEMDPKAPRH 451

  Fly   914 EITISDLRPHRNYTFTVVV-----RSGTESSVLRSSSPLSASFTTNEAVPGRV-ERFHPTDVQPS 972
              .:.:|.|:.|.:..:::     |..::.::::          |.|.|||.| :.|..:.....
Zfish   452 --VVGNLPPNTNVSLKMILTNPEGRKESDETLIQ----------TQEDVPGPVPKEFVRSTPSED 504

  Fly   973 EINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKN--------LKPGETYV 1029
            :|:.:|..| .|.||:|.|:.|:|:::::. |..:..........:..|        |.||.||.
Zfish   505 KISLQWKEP-LEPNGIITQYEISYSSVHSF-DPSVPLLRPPLLVSLPWNTSRYNFTLLHPGTTYQ 567

  Fly  1030 FKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYT 1094
            |.|:|.|:.||||......|..|.||...........:..:::||.:..:.  ...:...:..|.
Zfish   568 FLIRASTSKGFGPPTTLNVTTNISAPTLEEYDGSEASLNETATTITVLLKP--AQAKGAPISAYQ 630

  Fly  1095 IIVAEDD----AKNASGLEMPSWLDVQSY----SVWLPYQAIDPYYPFE--NRSVED---FTIGT 1146
            |:|.|.:    .:.|.|.|  .:.:..||    |..|||     |:..|  .|::::   ||:|
Zfish   631 IVVKEINPHRGRREAGGGE--CYREPVSYQSAVSSGLPY-----YFAAEIPPRNLQEPLPFTVG- 687

  Fly  1147 ENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDT---AYSFPIQTDQ--------DNTSLIV 1200
            :|...|  ||.|.||.....|.:..:|.:..:|.:.|   ..:|...|::        ..|..:|
Zfish   688 DNKTYH--GYWNAPLAPRKDYNIYFQAVSRVEKESKTQCLKLAFKGATEEPEVIPDPAKQTDQVV 750

  Fly  1201 AI----TVPLTIILVLLVTLLFYKRRRN--------NCRKTTKDSRANDNM-------SLPDSVI 1246
            .|    ...|..||::||.:|..|:||:        ...|..||:..|...       |:..|..
Zfish   751 KIAGISAAVLVFILLVLVAILLLKKRRSYYSYSYYLKLAKKRKDAIGNTRQEMTHMVNSMDRSYA 815

  Fly  1247 EQ------------------------NRPIL---------------------------------- 1253
            :|                        |.|::
Zfish   816 DQSTLHAEEPMTVTFMDSHNFSNRLPNEPLVPTAVLVPITDENHTAAAAAAENSRLLDIPRYHCE 880

  Fly  1254 ----------------IKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRF 1302
                            :.:..:|..||.....:.|.||:|.. ..|:......|....||.|||:
Zfish   881 GTESPYQTGQLHPAIRVADLLQHINLMKTSDSYGFKEEYESF-FEGQSASWDAAKKEQNRTKNRY 944

  Fly  1303 TNILPYDHSRFKLQPVDDDEGSDYINANYV---------------------------PGHNSPRE 1340
            .||:.|||||..|||::||..||||||||:                           .|:..|..
Zfish   945 GNIIAYDHSRVILQPMEDDPSSDYINANYIDVSGDAASSSIGERVRNVSPSLIWLYRDGYQRPSH 1009

  Fly  1341 FIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDS 1405
            :|.||||:|.|..|||||.|:..|..|||:|...|.||.||.:|||:|.  ..|||.||..:...
Zfish  1010 YIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDA--EVYGDFKVTFVEVE 1072

  Fly  1406 HYADWVMTEFMLCRG--SEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHC 1468
            ..|::|:..|.|.|.  :|.|.::.||||.|||.|||.....|:.|:|..:........||||||
Zfish  1073 PLAEYVVRTFTLERRGFNEVREVKQFHFTGWPDHGVPYHATGLLSFIRRVKMSNPPTAGPIVVHC 1137

  Fly  1469 SAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL-AVLEGKE 1532
            |||.||:|.:|.:|.:|........|||:..|.|:|..|:.|||||:|||.||..:| |.|.|:
Zfish  1138 SAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGE- 1201

  Fly  1533 NIVGPAREMHDNEGYEGQQVQLDENGDVVATIEGHLSHHDLQQAEAEAIDDENAAILHDDQQPLT 1597
                                      ..:...|...:::|:.:.::::    |::.|.|:.|.|.
Zfish  1202 --------------------------TAIPVCEFKAAYYDMIRIDSQS----NSSHLKDEFQTLN 1236

  Fly  1598 SSFTGHHTHMPPTTSMSSFGGGGGGHTNVDAPDRXHSVVNQSDNNNSVVIVLVDNKPSS-----M 1657
            |.     |..|.....|           :....| |      |.|.     .:||.|..     :
Zfish  1237 SV-----TPQPQPEDCS-----------IALLPRNH------DKNR-----FMDNLPPDRCLPFL 1274

  Fly  1658 ICKDSKGGN-IDVLESQQQQQQQQQQQP 1684
            |..|.:..| |:.......::.|..:||
Zfish  1275 ITIDGESSNYINAALMDPSEEYQSYRQP 1302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020	5/28 (18%)
		fn3	683..753	CDD:278470	22/129 (17%)
		fn3	787..850	CDD:278470	9/63 (14%)
		fn3	866..935	CDD:278470	16/91 (18%)
		fn3	961..1043	CDD:278470	26/90 (29%)
		PTPc	1272..1525	CDD:214550	117/281 (42%)
		PTPc	1298..1525	CDD:238006	109/255 (43%)
ptprk	XP_021324239.1	MAM	30..191	CDD:214533	19/102 (19%)
		IG_like	201..282	CDD:214653	16/81 (20%)
		fn3	293..370	CDD:306538	17/99 (17%)
		fn3	491..582	CDD:306538	27/92 (29%)
		PTPc	940..1195	CDD:238006	109/256 (43%)
		PTPc	1257..1495	CDD:238006	12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910