DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and ephb2b

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001314672.1	Gene:	ephb2b / 554232	ZFINID:	ZDB-GENE-050522-415	Length:	989	Species:	Danio rerio

Alignment Length:	961	Identity:	194/961 - (20%)
Similarity:	308/961 - (32%)	Gaps:	314/961 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   626 WV--RLPSVRSTEADITDMTKGEK------YTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQL 682
            |:  .||||.:.|..:.|.|....      |.:...:.|...|.....|...|:....|.|:...
Zfish     6 WILWTLPSVLAIEEILMDSTTATAELGWTVYPVSGTSDSSWEEVSGYDENMNTIRTYQVCNVFDA 70

  Fly   683 VDSRNITLEWPKPEG-------------------RV-----ESYILKWWPSD------------- 710
            ..:..:..::.:..|                   ||     |::.|.::.||
Zfish    71 NQNNWVRTKYIRRRGAQRIHVEMKFSVRDCSSIPRVPGSCKETFNLYYYESDSDTATKTFPPWME 135

  Fly   711 NPG-RVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILS--GITSL---YPRTMP 769
            ||. :|.|....|:.|..||.      |.:|     |.:.:..|:|.:|  |....   |...|.
Zfish   136 NPWIKVDTIAADESFSQVDLG------GRVM-----KINTEVRSFGPVSRNGFYLAFQDYGGCMS 189

  Fly   770 LIQSDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAE-----------IRDKEKLAN 823
            ||                .:.:.|...|::.....|::.:|..||           |.:.|::
Zfish   190 LI----------------AVRVFYRKCPRTIRNGAIFQETLSGAESTSLVAARGVCIPNAEEV-- 236

  Fly   824 DTDRKVTFTG----LVP-GR---------LYNITVW---------TVSGGVASL--PIQRQD--- 860
            |...|:...|    :|| ||         :.|.||.         |..|....|  ||..:.
Zfish   237 DVPIKLYCNGDGEWMVPIGRCMCKAGHEAVENGTVCRACPSGFFKTAQGDEKCLQCPINSRTTND 301

  Fly   861 ------------RLYPEPI----------TQLHATNITDTEISLRWDLPKGEYNDFDIAYLTADN 903
                        |...:|:          .|...:::.:|.:.|.|:.|:......|:.|    |
Zfish   302 GATNCVCRNGYYRTDSDPLEMPCTTVPSAPQNVISSVNETSLMLEWNPPRETGGRDDVVY----N 362

  Fly   904 LLAQNM----------------------TTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSP 946
            ::.::.                      .|.:.:.||||..|..|||.:...:|.......|...
Zfish   363 IICKSCGGGRGGCTRCGDNVQFIPRQLGLTESRVFISDLLAHTQYTFEIQAVNGVSDQSPYSPQY 427

  Fly   947 LSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFE 1011
            .|.:.|||:|.|..|...|........|...||.| .:.||||..:.:.|.. .:.|:......:
Zfish   428 TSVNITTNQAAPSTVSIMHQVSRTIDSITLSWSQP-DQPNGVILDYELQYYE-KDQTEHNSSMVK 490

  Fly  1012 SEEAFGVIKNLKPGETYVFKIQAKTAIGFG-----------PEREY----RQTMPILAPPRPATQ 1061
            |:....||:.||||..|||:::|:|..|||           .|.||    ::.:|::.....|..
Zfish   491 SQTNTAVIRGLKPGGIYVFQVRARTVAGFGRYSGKMYFQTMTEEEYNTSIQEKLPLIIGSAAAGL 555

  Fly  1062 VVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQ 1126
            |....|.........|..:...|:...:::.||           ||...|.   ::.|
Zfish   556 VFLIAVVVIIIVCNRRGFERADSEYTDKLQHYT-----------SGHMSPG---MKIY------- 599

  Fly  1127 AIDPY-YPFENRSVEDFTIGTE-NC--DNHKIG------YCNGPLKSGTTYRVKVRAFTGADKFT 1181
             |||: |...|.:|.:|....: :|  ....||      .|:|.||......:.|...|....:|
Zfish   600 -IDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGNLKLPGKREMFVAIKTLKSGYT 663

  Fly  1182 D-------TAYSFPIQTDQDNT---SLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRAN 1236
            :       :..|...|.|..|.   ..:|..:.|:.||...:
Zfish   664 EKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSSPVMIITEFM----------------------- 705

  Fly  1237 DNMSLPDSVIEQN------------------------------RPILIKNFAEHYRLMSADSDFR 1271
            :|.|| ||.:.||                              |.:..:|...:..|:...|||.
Zfish   706 ENGSL-DSFLRQNDGQFTVIQLVGMLRGIASGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFG 769

  Fly  1272 FSEEFEE-------LKHVGRDQPCTFADLPCNRPKNRFTN--------ILPYDHSRFKLQPVDDD 1321
            .|...|:       ...:|...|..:. .|......:||:        |:.::...:..:|..|.
Zfish   770 LSRFLEDDTSDPTYTSALGGKIPIRWT-APEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDM 833

  Fly  1322 EGSDYINA-----NYVPGHNSPREFIVTQGPLHSTRDDFWRMCWES--NSR 1365
            ...|.|||     ...|..:.|       ..||....|    ||:.  |:|
Zfish   834 TNQDVINAIEQDYRLPPPMDCP-------SALHQLMLD----CWQKDRNNR 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020	12/52 (23%)
		fn3	683..753	CDD:278470	18/107 (17%)
		fn3	787..850	CDD:278470	19/96 (20%)
		fn3	866..935	CDD:278470	18/100 (18%)
		fn3	961..1043	CDD:278470	27/92 (29%)
		PTPc	1272..1525	CDD:214550	23/116 (20%)
		PTPc	1298..1525	CDD:238006	18/83 (22%)
ephb2b	NP_001314672.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11636
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000