DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptprh

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_011248936.1	Gene:	Ptprh / 545902	MGIID:	3026877	Length:	1153	Species:	Mus musculus

Alignment Length:	1271	Identity:	346/1271 - (27%)
Similarity:	529/1271 - (41%)	Gaps:	233/1271 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   346 YQVSVATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRN 410
            |..||......|.....:.|.:.::|....|            ...|:|.|.....|..|.||||
Mouse    20 YGCSVVRAAGTSVTVDRHAPASSYEFSMWVE------------KDGVSSSPQIPVTTAAPNPVRN 72

  Fly   411 LRSINDDKTNTMIITWE-ADPASTQDEYRIVY-HELETFNGDTSTLTTDRTRFTLESLLPGRNYS 473
            || :......::.::|| .|.:|.|.   :.| .:.....|.|.|..|..|..|::.|.||.:|.
Mouse    73 LR-VEGQNNISISLSWEPPDQSSLQG---LTYWTQCSRHGGQTETRNTTDTSVTVDGLDPGSSYE 133

  Fly   474 LSVQAVSKKMESNETSIFVVTRPSSPI----IEDLKSIRMGLNISWK-SDVNSKQE-QYEVLYSR 532
            .||......:.|...::...|.| :|:    :|...:|  .:::||: .|.:|.|. .|....||
Mouse   134 CSVWVEKDGLYSKNETLNTSTAP-NPVRNLRVEGQNNI--SISLSWEPPDQSSLQGLTYWAQCSR 195

  Fly   533 NGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSN 597
            :| ....|:.|.::.:.:..|.||:.||..|:.....:.|..........|||.||:.:|...:.
Mouse   196 HG-GQTETRNTTDTSVTVDGLDPGSSYECSVWVEKDGVYSTNETLSNTTAPNPVRNLRVEGQNNI 259

  Fly   598 SVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADIT--DMTKGEKYTIQVNTVSFGVE 660
            |:.:.|.||:....  ..:.|.....:...:..:..:|:..||  .:..|..|...|.....||.
Mouse   260 SISLSWEPPDQPSL--QGLTYWAQCSRHGGQTETRNTTDTSITVDGLDPGSSYECSVWVEKDGVY 322

  Fly   661 SPVPQEVNTTVPPNPVSNIIQLVDSRN---ITLEWPKPEGRVESYILKWWP--SDNPGRVQTKNV 720
            | ..:.::.|..||||.|:  .|:.:|   |:|.|..|: :.....|.:|.  |.:.|:.:|:|.
Mouse   323 S-TNETLSNTTAPNPVRNL--RVEGQNNISISLSWEPPD-QPSLQGLTYWAQCSRHGGQTETRNT 383

  Fly   721 SENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDE 785
            ::..         |.:..|.||..|:..:.....|:.|...:|...|:| |.:...|.|...|.:
Mouse   384 ADTS---------VTVDGLDPGSSYECSVWVEKDGVYSTNETLNTSTVP-ISAPNPVRNLRVEGQ 438

  Fly   786 RD-TITLSYTPTPQSSSKFDIYRFSL----GDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVW 845
            .: :|:||:.|..|.|.:...|....    |..|.|      |.||..:|..||.||..|..:||
Mouse   439 NNISISLSWEPPDQPSLQGLTYWAQCSRHGGQTETR------NTTDTSITVDGLDPGSSYECSVW 497

  Fly   846 TVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNMT 910
            ....||.|......:...|.|:..|...:..:..|||.|: |..:.:...:.|....:.......
Mouse   498 VEKDGVYSTNETLSNTTAPNPVRNLRVKSQNNFSISLSWE-PPDQPSLQGLIYWAQCSRHGGQTE 561

  Fly   911 TRN----EITISDLRPHRNYTFTVVVRS----GTESSVLRSSSPLSASF-TTNEAVPGRVERFHP 966
            |||    .:|:..|.|...|..:|.|..    .|..::..|:.|:|||. ..|..|.|: ..|
Mouse   562 TRNTTDTSVTVDGLDPGFLYKCSVWVEKDGVYSTNETLNTSTVPISASNPVRNLRVEGQ-NNF-- 623

  Fly   967 TDVQPSEINFEWSLP-SSEANGVIRQFSIAY----------TNINNLTDAGMQDFESEEAFGVIK 1020
                  .|:..|..| .|...|      :.|          |...|..|..:          .:.
Mouse   624 ------SISLSWEPPDQSSLQG------LTYWAQCSRHGGQTETRNTADTSV----------TVD 666

  Fly  1021 NLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSD 1085
            .|.||.:|...:                            .|....||.::.|:
Mouse   667 GLDPGSSYECSV----------------------------WVEKDGVYSTNETL----------- 692

  Fly  1086 QNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQS-------YSVWLPYQAIDPYYPFENRSVEDFT 1143
                              |.|  .:|:.:::.|       |.|.|
Mouse   693 ------------------NTS--TVPAAVNITSCISTSGGYGVLL-------------------- 717

  Fly  1144 IGTENCDNHKIGYCNGPLKSGTTYR----------VKVRAFTGADKFTDT---------AYSFPI 1189
              |.:|.:.  ||.:..:|.|..:|          |.|.....|..:|.|         |.|...
Mouse   718 --TWSCPSG--GYESFEVKVGRKWRSENGSLCGKGVTVSDLEPAQSYTATVTTVFKDLKAQSLST 778

  Fly  1190 QTDQDNTSLIVAITVPLTIILVLL-VTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPIL 1253
            ....::.::|....|.:.::.:|: :.::|.||||.  ::..|:...:...|.|..       ||
Mouse   779 TCHTESAAIIAGAIVGILLLFILVGLLIVFLKRRRK--KRQPKEVPKDLVCSCPGD-------IL 834

  Fly  1254 IKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPV 1318
            .|:||:|.|....||:..|:||:::|...|:.|....|....||.|||:.|:||||.||..|||:
Mouse   835 AKDFADHVRENEKDSNCGFAEEYQQLALEGQGQSQITASALENRSKNRYRNVLPYDWSRVPLQPL 899

  Fly  1319 DDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQ 1383
            .::.|||||||:::||..||:|||.|||||.:|..|||||.||..|..:||||.|.|.||.||:.
Mouse   900 QEEPGSDYINASFMPGLWSPKEFIATQGPLPNTVGDFWRMVWEQQSHTLVMLTNCMESGRVKCEH 964

  Fly  1384 YWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRI--LRHFHFTTWPDFGVPNPPQTL 1446
            |||.|..|..:|.::|.::::....:|.:....|....||:.  ||.||:..|||.|||..|..|
Mouse   965 YWPLDAQPCIHGQLQVMLISEEASENWTVRHLQLFHMKEQQTLSLRQFHYLAWPDHGVPYSPDPL 1029

  Fly  1447 VRF---VRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERV 1508
            :.|   :|.:.|:. .:..|.:|||||||||:||.|.||.:|:|:.....|..|..|..||:.|.
Mouse  1030 LAFRKMLRQWMDQT-TDGGPPIVHCSAGVGRTGTLIALDVLLRQLECEGLVGPFSFVKKMRESRP 1093

  Fly  1509 WMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDN 1544
            .|||||.||:.:|||:|..|:.....:.|...|::|
Mouse  1094 LMVQTEAQYVFLHQCILKSLQKPAPALVPEEAMYEN 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470	7/44 (16%)
		FN3	405..494	CDD:238020	26/90 (29%)
		FN3	511..574	CDD:238020	18/64 (28%)
		FN3	583..671	CDD:238020	20/89 (22%)
		fn3	683..753	CDD:278470	17/74 (23%)
		fn3	787..850	CDD:278470	21/67 (31%)
		fn3	866..935	CDD:278470	17/76 (22%)
		fn3	961..1043	CDD:278470	14/92 (15%)
		PTPc	1272..1525	CDD:214550	119/257 (46%)
		PTPc	1298..1525	CDD:238006	110/231 (48%)
Ptprh	XP_011248936.1	FN3	67..146	CDD:238020	25/82 (30%)
		FN3	156..234	CDD:238020	21/81 (26%)
		FN3	245..323	CDD:238020	19/79 (24%)
		FN3	334..412	CDD:214495	23/89 (26%)
		FN3	427..505	CDD:238020	26/83 (31%)
		FN3	516..594	CDD:238020	18/78 (23%)
		FN3	611..687	CDD:214495	19/128 (15%)
		PTP_DSP_cys	881..1113	CDD:391942	110/232 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920