Protein Alignment Ptp10D and PLCG1

DIOPT Version :9

• Sequence 1: NP_996413.2
• Gene: Ptp10D / 32115
• FlyBaseID: FBgn0004370
• Length: 1990
• Species: Drosophila melanogaster
• Sequence 2: XP_005260495.1
• Gene: PLCG1 / 5335
• HGNCID: 9065
• Length: 1330
• Species: Homo sapiens
• Alignment Length: 1039
• Identity: 185/1039 - (17%)
• Similarity: 325/1039 - (31%)
• Gaps: 352/1039 - (33%)

  Fly   617 RYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQ 681
            ||:.|        |:.|..::....:..|.::.::    :..:::....|||..     :..:..
Human    92 RYQED--------PAFRPDQSHCFVILYGMEFRLK----TLSLQATSEDEVNMW-----IKGLTW 139

  Fly   682 LVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQY- 745
            |::.   ||:.|.|. ::|.::.|.:.|.:      :|..:..||.||..:...:...:|.:::
Human   140 LMED---TLQAPTPL-QIERWLRKQFYSVD------RNREDRISAKDLKNMLSQVNYRVPNMRFL 194

  Fly   746 ---KFDIQTTSYGILSG-ITSLY-------PRTM--PLIQSDVVVANGEKED-------ERDTIT 790
               ..|::..|..|..| ...||       .:||  |.:::..:.| ||:.:       |.....
Human   195 RERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA-GERPELCRVSLPEFQQFL 258

  Fly   791 LSYTPTPQSSSKFDIYRFSLGDAE--IRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVAS 853
            |.|.....:..:..:..|.|....  :|:.|:.....|..|||.......::|..:..|.....:
Human   259 LDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLDAVCPDTMN 323

  Fly   854 LPIQRQDRLYPEPITQLHATNITDTEIS-----------LR----------WDLPKGEYNDFDIA 897
            .|:...      .|:..|.|.:|..:.|           ||          ||.|.|    ..:.
Human   324 NPLSHY------WISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDG----MPVI 378

  Fly   898 YLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVP---G 959
            |        ...|...:|..||           |:.:..|.:.:.|..|:..|...:.::.   .
Human   379 Y--------HGHTLTTKIKFSD-----------VLHTIKEHAFVASEYPVILSIEDHCSIAQQRN 424

  Fly   960 RVERFHPT--D---VQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVI 1019
            ..:.|...  |   .:|.||:.: .|||  .|.:.|:..|.:
Human   425 MAQYFKKVLGDTLLTKPVEISAD-GLPS--PNQLKRKILIKH----------------------- 463

  Fly  1020 KNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFS 1084
            |.|..|..|                                :.|||.:..|.:.|.       .|
Human   464 KKLAEGSAY--------------------------------EEVPTSMMYSENDIS-------NS 489

  Fly  1085 DQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAI----DPYYPFENRS------- 1138
            .:||      |:..||...:.                |.|:..:    ..||..|..|
Human   490 IKNG------ILYLEDPVNHE----------------WYPHYFVLTSSKIYYSEETSSDQGNEDE 532

  Fly  1139 --VEDFTIGTENCDNHKIGYCNGPLKSGTTYR-VKVRAFTGADKFTDTAYSFPIQTDQDNTSLIV 1200
              .::.:..||...|.|  :.:|.|.:|...| :..|..|          .:.|:|...:.|.:|
Human   533 EEPKEVSSSTELHSNEK--WFHGKLGAGRDGRHIAERLLT----------EYCIETGAPDGSFLV 585

  Fly  1201 AITVPLTIILVLLVTLLFYKRRR-NNCRKTTKDSRANDNMSLPDSVIEQNRPILIKNFAEHYRLM 1264
            ..:.    ..|...||.|::..: .:||..::.........|.|:::
Human   586 RESE----TFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLV------------------ 628

  Fly  1265 SADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINA 1329
                   |...::.:.|..:      ..|.||..:.|.:..:|..::.         |..::.:|
Human   629 -------FDSLYDLITHYQQ------VPLRCNEFEMRLSEPVPQTNAH---------ESKEWYHA 671

  Fly  1330 NYVPGHNSPREFIVTQGPLHSTRDDFW--RMCWESNSRAIVMLTRCFEKGREK-CDQYWPNDTVP 1391
            :..   .:..|.::.:.|    ||..:  |...|.||.||....    :|:.| |.......|
Human   672 SLT---RAQAEHMLMRVP----RDGAFLVRKRNEPNSYAISFRA----EGKIKHCRVQQEGQT-- 723

  Fly  1392 VFYGDIKVQILND--SHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGV------------PNP 1442
            |..|:.:...|.|  |:|....:...|..|............|..||:|.            .||
Human   724 VMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANP 788

  Fly  1443 PQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQIN-------TSDYVDIFGIV 1500
            ..|....|:|..|.....:..:            |||. ..|:|.:.       ..||..
Human   789 MPTFKCAVKALFDYKAQREDEL------------TFIK-SAIIQNVEKQEGGWWRGDYGG----- 835

  Fly  1501 YAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDEN---GDVV 1561
                |:::|.   ...|:             |.:|.|.       ..|.::..||||   ||::
Human   836 ----KKQLWF---PSNYV-------------EEMVNPV-------ALEPEREHLDENSPLGDLL 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020	9/53 (17%)
		fn3	683..753	CDD:278470	14/73 (19%)
		fn3	787..850	CDD:278470	12/64 (19%)
		fn3	866..935	CDD:278470	17/89 (19%)
		fn3	961..1043	CDD:278470	15/86 (17%)
		PTPc	1272..1525	CDD:214550	51/276 (18%)
		PTPc	1298..1525	CDD:238006	46/250 (18%)
PLCG1	XP_005260495.1	PH_PLC_gamma	29..151	CDD:270168	13/78 (17%)
		PH	<71..142	CDD:278594	10/66 (15%)
		PI-PLCc_gamma	319..>466	CDD:176534	34/201 (17%)
		PH-like	489..>523	CDD:302622	10/55 (18%)
		SH2_N-SH2_PLC_gamma_like	545..649	CDD:199829	25/150 (17%)
		SH2_C-SH2_PLC_gamma_like	663..765	CDD:198186	24/123 (20%)
		SH3_PLCgamma1	791..850	CDD:212903	15/96 (16%)
		PHsplit_PLC_gamma	<864..933	CDD:270054	4/9 (44%)
		PLCYc	954..1069	CDD:128454
		C2_PLC_like	1087..1250	CDD:175974

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910