DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and ptprz1a

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_005163194.1	Gene:	ptprz1a / 497461	ZFINID:	ZDB-GENE-090406-1	Length:	1827	Species:	Danio rerio

Alignment Length:	1772	Identity:	393/1772 - (22%)
Similarity:	641/1772 - (36%)	Gaps:	546/1772 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RCADL--AISIPNNPGLDDGASYRLDYSPPFGYPEPNTTIASREIGDEIQFSRALPGTKYNFWLY 103
            |||..  .|::.:|.||.:...||                :.:::.:.::            |.|
Zfish     7 RCAFFLAQIALFSNTGLSEAYGYR----------------SQKKLSENVE------------WSY 43

  Fly   104 YTNFTHHDWLTWTVTITTAPDPPSNL-----SVQVRSGKNAIILWSPPTQGSYTA---------- 153
            ......::|.....:...|...|.|:     .|:::..|..:..|...|..|.|.
Zfish    44 AGTLNQNNWAKKYPSCNNAKQSPINVEESLAQVKIQFQKLRLEGWLEKTSDSTTVKNDGKTVAID 108

  Fly   154 ---------------FKIKVL----GLSEASS----------SYNRTFQVN----------DNTF 179
                           ||:..:    ||..|||          .|....|:.          |..|
Zfish   109 VGGEFYVSGGGLRSKFKVGRISFHWGLCNASSDGSEHGLNGEKYPLEMQIYCYEADVFSDLDEAF 173

  Fly   180 QHSVKELTPGATYQVQA-----YT-IYDGKESVAYTSRN-----FTTK---PNTPGKFIVWFRNE 230
            :...|.......::...     || |.|...||:...::     ||.:   |::..|:.::..:.
Zfish   174 REGGKITALAVLFETSTEDNVNYTAIIDAVNSVSRYGKSGSISPFTMQGLLPSSTEKYFIYNGSL 238

  Fly   231 TTLLVLWQPPYPAGI-YTHYKVSIEPPDAN----------DSVLYV-----------EKEGEPPG 273
            ||      ||....: :..:|.::...|..          ..|.||           .::.:..|
Zfish   239 TT------PPCSETVEWIVFKNTVAISDVQLEMFCEVMTMQQVGYVMLMDYLQNNYRNQQEQFMG 297

  Fly   274 PAQAAFKGLVPGRAYNISVQTMSEDEISLP-TTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAP 337
            ...:::.|:               :|:..| .:::...|...|.|.|         |..|:||.|
Zfish   298 QVFSSYTGV---------------EEVHTPICSSEPENVQASPHNYT---------SMLVIWERP 338

  Fly   338 KGI--SEFDKYQVSVATTRRQSTVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGD 400
            :.:  |..::|.|:..        |...:..:..::  :.:..:....|::.:....:.......
Zfish   339 RAVYDSSIERYSVTYR--------PAQGDDESALEY--LTDGDQDVGAIIQDLVANTSYMVQVVA 393

  Fly   401 VTLRPLPVRNLRSINDDKTNTMIITWEADPASTQDEYRIVYHELETFNGDTSTLTTDRTRFTLES 465
            |....|..|    ::|..|..:.:.   ||.:..|.....|.|.|.::.:...:..:..|
Zfish   394 VCTNGLYGR----VSDQLTVDVPLD---DPEADNDSESFDYDEEENYHINPFLIRPETER----- 446

  Fly   466 LLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSPIIEDLKSIRMGLNISWKSDVNSKQEQYEVLY 530
             ||   |.......|.::.:.|..|       .|:::
Zfish   447 -LP---YPFQTTTTSPRVTTTERLI-------HPVVK---------------------------- 472

  Fly   531 SRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIE--- 592
                    .||:|.|.||.::..|.           :||      ..|..||.:.|.....:
Zfish   473 --------TTQRTHERRLPVEESQK-----------THD------DIFPVVYTDKPTAKHTDQPT 512

  Fly   593 TVRSNSVL-VHWSPPESGEF-----TEYSIRYR--TDSE-----------QQWVRLPSVRSTEAD 638
            |:.:..|: ||.:.|:|..|     :|..::..  |||.           :::|...|:...|.:
Zfish   513 TITTTFVVDVHTTTPDSFRFIAGVSSESDVQSSSFTDSPTSVTPETSETLERFVTSASIDILEVE 577

  Fly   639 -------ITDMTKGEKYT------IQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITL 690
                   |||..:....|      |.|::.|....|.||....|...|.|.:.....|.|:...
Zfish   578 DVTEPVTITDSFEESSQTVAPLLEIPVDSTSSTFPSEVPLWPTTASLPFPATAAFSTVLSQTTQ- 641

  Fly   691 EWPKPEGRVESYILKWWP--SDNPGRVQTKNVSENKSADDLS----------TVRVLIG----EL 739
              |...|....|.    |  ||....|....||....:..||          ||.:|:.    .:
Zfish   642 --PVFNGESAPYA----PSVSDTLSYVHASPVSPYSLSSVLSEPIPDWDIPYTVTMLVSGGAQSI 700

  Fly   740 MPGVQYK----------FDIQTTSYG----------ILSGITSLYP---RTMPLIQSDVVVANGE 781
            .|...|.          .|:::.|.|          :|||..|..|   .|:||
Zfish   701 TPSPSYPTLSLSGSVSYLDMESVSSGGCIDDDGDDAVLSGSASADPPCRTTLPL----------- 754

  Fly   782 KEDERDTITLSYTP-TPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVW 845
              .....:|.|..| .|.|.|.                                    |.:::..
Zfish   755 --QTLSEVTASVDPMLPSSESS------------------------------------LLHLSEH 781

  Fly   846 TVSGGVASLPIQRQDRLYPEPITQLHATNIT--DTEISLRWDLPKGEYN------DFDIAYLTAD 902
            :.:..|.|.|...|..:   |:::.::|..|  ||:.||...  .||.|      |..:|..|..
Zfish   782 SGTISVLSTPAYLQPSV---PVSKDYSTTTTTLDTDASLLGS--NGESNLLTEWVDSSLAAPTFS 841

  Fly   903 NLLAQNMTTRNEI--TISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFH 965
            :..:.:.::.:.:  ::|.|.|     .:.::.:..|..:.:|:|..|.|..::..:....:...
Zfish   842 SKFSLHASSNSLLPSSVSGLPP-----CSSLLSNPVELHLFQSTSSASTSLCSDAGLDLSTKALL 901

  Fly   966 PTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETYVF 1030
            |:      ::.. :.|||:.:     .|:|.| :||:..:.:     .::.|....::
Zfish   902 PS------LSIS-TKPSSDLS-----LSVAAT-VNNIAQSAI-----GQSLGASAPIR------- 941

  Fly  1031 KIQAKTAIGFGPEREYRQT-----MPILAPPRPA------TQVVPTEVYRSSSTIQIRFRKNYFS 1084
                .:||...|..|.|.|     .|.:||..|:      ..|||..:..||:. :......:.:
Zfish   942 ----SSAITTTPILELRSTPTPVVPPTIAPTSPSDSITVVAPVVPPTIPVSSAP-ESSSMPTHSA 1001

  Fly  1085 D--QNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTE 1147
            |  |......:|..: :....:|||.|          |:..||  |....|.| .|.|:...|.|
Zfish  1002 DGQQENSASGWTFDL-DWGQSSASGDE----------SIAAPY--ITTASPTE-VSPEETDDGNE 1052

  Fly  1148 NCDNHKIGYC----NGPLKSGTTYRVKVR-----------------AFTGADKFTDTAYSFPIQT 1191
               .|...:.    ||.....|.:||.::                 ..|..|..|.:.:|.|.:|
Zfish  1053 ---EHSSSFYFEGENGTESEVTDFRVTLQPSPSWTLRGSWEEESGSGETLTDNETSSDFSIPERT 1114

  Fly  1192 ----------DQDNTS------LIVAI------TVPLTII-------LVLLVTLLFYKRRRNNCR 1227
                      |.:|:|      |..:|      .|||.::       |:.|:.:..|.|:   |.
Zfish  1115 ERESEEEPVEDANNSSHESRVGLASSIERQKKAVVPLAVVSTLTFLGLIFLIGIYIYWRK---CF 1176

  Fly  1228 KTT----KDS---RANDNMSLPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRD 1285
            :|.    :||   |...::.|.:...| :.|:.:|.|..|...:...|.  ||.|||.||....:
Zfish  1177 QTAHFYIEDSTSPRVISSLPLLNPTGE-HEPLPVKQFVNHVTELHNTSS--FSREFEILKEYFEE 1238

  Fly  1286 -QPCTFADL---------PCNRPKNRFTNILPYDHSRFKLQPVDDDE---GSDYINANYVPGHNS 1337
             |.|| .||         |.|:.|||:.|||.|||||.:|.|::|.:   |.||||||||.|.|.
Zfish  1239 VQTCT-VDLGTTTDCSNHPDNKNKNRYVNILAYDHSRVRLAPLNDKDGKSGGDYINANYVDGFNK 1302

  Fly  1338 PREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQIL 1402
            .:.:|..||||.|:..|||||.||.|...|||:|...||||:|||||||.:.... ||...|.:.
Zfish  1303 NKAYIAAQGPLKSSTPDFWRMVWEQNVGVIVMITNLVEKGRKKCDQYWPLENREE-YGCFLVTVK 1366

  Fly  1403 NDSHYADWVMTEFML-----CRGSE-----QRILRHFHFTTWPDFGVPNPPQTLVRFV----RAF 1453
            :.:..|.:....|.|     .:||:     :|.:..:|:|.|||.|||.....::.||    :|.
Zfish  1367 STNVLAYYTKRTFTLRNTSIKKGSQRYRSNERTVTQYHYTQWPDMGVPEYVLPVLSFVYKSSKAQ 1431

  Fly  1454 RDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYI 1518
            .|.:|    |:||||||||||:||:|.||.:|:||.....|:|.|.:..:|.:|.::||||:|||
Zfish  1432 TDGMG----PMVVHCSAGVGRTGTYIVLDSMLKQIKEKGTVNIMGFLKHIRTQRNYLVQTEEQYI 1492

  Fly  1519 CIHQCLLAVLEGKENIV 1535
            ..|..|:..:..:|..|
Zfish  1493 FTHDALVEAILSQETEV 1509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	24/140 (17%)
		fn3	220..304	CDD:278470	14/106 (13%)
		fn3	315..391	CDD:278470	13/77 (17%)
		FN3	405..494	CDD:238020	17/88 (19%)
		FN3	511..574	CDD:238020	9/62 (15%)
		FN3	583..671	CDD:238020	26/122 (21%)
		fn3	683..753	CDD:278470	19/95 (20%)
		fn3	787..850	CDD:278470	7/63 (11%)
		fn3	866..935	CDD:278470	16/78 (21%)
		fn3	961..1043	CDD:278470	12/81 (15%)
		PTPc	1272..1525	CDD:214550	122/279 (44%)
		PTPc	1298..1525	CDD:238006	108/243 (44%)
ptprz1a	XP_005163194.1	alpha_CARP_receptor_like	48..301	CDD:239396	42/258 (16%)
		fn3	316..398	CDD:278470	15/100 (15%)
		PTPc	1225..1500	CDD:214550	123/280 (44%)
		PTPc	1261..1500	CDD:238006	109/243 (45%)
		PTPc	1532..1791	CDD:214550
		PTPc	1559..1791	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910