DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and ptpn4b

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:XP_005174003.1 Gene:ptpn4b / 407634 ZFINID:ZDB-GENE-030131-6259 Length:935 Species:Danio rerio


Alignment Length:1256 Identity:250/1256 - (19%)
Similarity:401/1256 - (31%) Gaps:501/1256 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   420 NTMII--TWEADPASTQDEYRI----VYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQA 478
            |.:::  |.:....:.||:.:|    ||..||         .|:|..|.|:              
Zfish    32 NVLLLDNTVQTFRVNKQDQGQILLDVVYKHLE---------LTERDYFGLQ-------------- 73

  Fly   479 VSKKMESNETSIFVVTRPSSPIIEDLK-----SIRMGLNISWKSDVNSKQEQY-EVLYSRNGTSD 537
              ...::::|..::  .|:.|:.:.||     ::|..:.. :..|....||:| ..||......|
Zfish    74 --LADDTSDTQRWL--DPNKPVRKQLKRPSPHNLRFRVKF-FVGDPGKLQEEYTRYLYFLQLKQD 133

  Fly   538 LRTQK--TKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVY-------PNPPRNMTIE- 592
            :.:.:  ..::..|:          |..:||..:|....|:...:.|       ||||::...| 
Zfish   134 ILSGRLPCPQNTAVL----------LASYAVQAELGDYSHSEHLSGYLSEYSFIPNPPQDFEKEV 188

  Fly   593 ------------------------TVRSNSVLVHWSPPE----------SGEFTEYSIRYRTDSE 623
                                    |:....|.:|::...          |...:.|..|.|. :.
Zfish   189 AKLHQEHNGLTPAQSEFNYLNAARTLELYGVELHYARDHCNTEIYVGVLSAGISVYKDRVRV-NH 252

  Fly   624 QQWVRLPSVRSTEADITDMTKGEKYTIQV-------------------------------NTVSF 657
            ..|.::..:         ..|.:::.||:                               |...|
Zfish   253 FPWFKIVKI---------SFKSKQFFIQLRKELTECRESLLGFNMMNYRACKNLWKSCVENHTFF 308

  Fly   658 GVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSE 722
            .:|.|||.|                   ||:.|.: ...|....|.         ||.:.::|..
Zfish   309 RLERPVPPE-------------------RNLFLHY-FTLGSKFRYC---------GRTEAQSVQY 344

  Fly   723 NKSADDLSTV------RVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGE 781
            .|...:.:.|      :.|:..||.|:    |.:|.|...||                       
Zfish   345 GKERGNKNRVFARSPSKPLVRRLMSGL----DWETVSRNSLS----------------------- 382

  Fly   782 KEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWT 846
             :|..:|.:|.....|.|..                                      ::.:|:|
Zfish   383 -DDRLETQSLPNRSPPDSPD--------------------------------------HSNSVFT 408

  Fly   847 VSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNMTT 911
            ..|.          |:.|..|..| ..::.|       |.|                  .|..|.
Zfish   409 TEGA----------RIRPSSIGHL-VDHVID-------DSP------------------CQTFTN 437

  Fly   912 RNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVP---------------GRV 961
                       |::       .|.|:::.:...|..|...||:|..|               ||.
Zfish   438 -----------HKS-------ASSTQANSISLDSTPSPDVTTDEQPPALPPKQFRKDPLNHNGRS 484

  Fly   962 ERFHPTDVQP--SEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKP 1024
            :..|..|...  ||:   :::|:  |:|.....::.:.|:                  |:..::|
Zfish   485 QSQHELDDHDHLSEL---YNVPA--ASGKSMNGAVPHDNL------------------VLIKMRP 526

  Fly  1025 GETYVFKIQAKTAIGFGPEREYRQTMPIL----APPRPATQVVPTEVYRSSSTIQIRFR------ 1079
            .|...|        ||..:....|.|||:    ||..||...|| .:......:.|..|      
Zfish   527 DENGRF--------GFNVKGGVDQRMPIIVSRVAPGTPADMCVP-RLNEGDQVVLINGRDISDHT 582

  Fly  1080 --------KNYFSDQNGQ----VRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYY 1132
                    |....||:|:    ||...|...:::.:.         ||::               
Zfish   583 HDDVVMIIKASCEDQSGELILLVRPNAIYDVDEEQEK---------LDLE--------------- 623

  Fly  1133 PFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTS 1197
                   .||....|.|.                    :.:.:.||....:     ||..:|.  
Zfish   624 -------PDFQYIPEACG--------------------LESHSEADSLRSS-----IQLLRDG-- 654

  Fly  1198 LIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIKNFAEHYR 1262
             :.:.|||                                                 ..|.:.||
Zfish   655 -LASGTVP-------------------------------------------------AQFDQLYR 669

  Fly  1263 LMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYI 1327
                             |..|....|  |.||.|..|||:.:|.|||.:|..|:..:     |||
Zfish   670 -----------------KRPGMSMSC--ARLPQNVSKNRYRDISPYDSTRVVLKGTE-----DYI 710

  Fly  1328 NANY----VPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPND 1388
            |||:    ||.....|.:|..||||..|..|||:|.||.::..:||||...|:||.||.|||||.
Zfish   711 NANFINMDVPSKGEVRRYIACQGPLPGTCSDFWQMVWEQSAALVVMLTTQVERGRVKCHQYWPNV 775

  Fly  1389 TVPVFYGDIKVQILNDSHYADWVMTEFML--CRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVR 1451
            :....||..:|..:::...:.:::.:..|  ....|:|.:....:..|||.|||:.....:.||.
Zfish   776 SASGTYGGFQVTCVSEEGNSAYLLRDLTLTHLESKEERQICQMQYLAWPDHGVPDDSSDFLNFVS 840

  Fly  1452 AFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQ 1516
            ..|.:......|:|||||||:||:|..||::..:..|.....|....||..||.:|..|:||..|
Zfish   841 QVRSKRADGPEPVVVHCSAGIGRTGVLITMETAMCLIEGGQSVYPLDIVRTMRDQRAMMIQTPSQ 905

  Fly  1517 YICIHQCLLAVLEGKENIVGP 1537
            |..:.:.:|.|.:  |.||.|
Zfish   906 YRFVCEAILKVYD--EEIVKP 924

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470
fn3 220..304 CDD:278470
fn3 315..391 CDD:278470
FN3 405..494 CDD:238020 14/79 (18%)
FN3 511..574 CDD:238020 12/65 (18%)
FN3 583..671 CDD:238020 23/153 (15%)
fn3 683..753 CDD:278470 16/75 (21%)
fn3 787..850 CDD:278470 6/62 (10%)
fn3 866..935 CDD:278470 8/68 (12%)
fn3 961..1043 CDD:278470 14/83 (17%)
PTPc 1272..1525 CDD:214550 91/258 (35%)
PTPc 1298..1525 CDD:238006 84/232 (36%)
ptpn4bXP_005174003.1 B41 30..222 CDD:214604 40/227 (18%)
FERM_N 33..97 CDD:286467 16/90 (18%)
FERM_B-lobe 122..214 CDD:271216 15/101 (15%)
FERM_C_PTPN4_PTPN3_like 216..310 CDD:270010 12/103 (12%)
FA 325..365 CDD:285894 8/48 (17%)
PDZ_signaling 519..606 CDD:238492 22/113 (19%)
PTPc 662..915 CDD:214550 94/276 (34%)
PTPc 687..914 CDD:238006 84/231 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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