Protein Alignment Ptp10D and Ptp69D

DIOPT Version :10

• Sequence 1: NP_996413.2
• Gene: Ptp10D / 32115
• FlyBaseID: FBgn0004370
• Length: 1990
• Species: Drosophila melanogaster
• Sequence 2: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Alignment Length: 1339
• Identity: 309/1339 - (23%)
• Similarity: 512/1339 - (38%)
• Gaps: 362/1339 - (27%)

  Fly   469 GRNYSLSV----QAVSKKM-----ESNETSIFVVTRPSSPIIEDLKSIRMGLN-------ISWKS 517
            |:|.||..    :||:.|:     ..|.|...:.|.|       |||...|..       |.:|:
  Fly    38 GKNVSLECASENEAVAWKLGNQTINKNHTRYKIRTEP-------LKSNDDGSENNDSQDFIKYKN 95

  Fly   518 -----DVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAY 577
                 |||.|.       |.|.|...:|.:...:...::...|....:.....:...::.:...|
  Fly    96 VLALLDVNIKD-------SGNYTCTAQTGQNHSTEFQVRPYLPSKVLQSTPDRIKRKIKQDVMLY 153

  Fly   578 -FQAVYP-NPPRNMTIETVRSNSVLVHWSPPESGEF--TEYSIRYRTDSEQQWVRLPSVRSTEAD 638
             ...:|| |...|..::.::..|..         ||  |..||....|:...:.         .:
  Fly   154 CLIEMYPQNETTNRNLKWLKDGSQF---------EFLDTFSSISKLNDTHLNFT---------LE 200

  Fly   639 ITDMTKGE----KYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRV 699
            .|::.|.|    |.|:..:|   |:|. ..:|:...|...|           .:::::.|..|..
  Fly   201 FTEVYKKENGTYKCTVFDDT---GLEI-TSKEITLFVMEVP-----------QVSIDFAKAVGAN 250

  Fly   700 ESYILKWWPSDNPGRVQ----------TKNVSENKSADDLSTVRVLIGELMPGVQYKFDI----- 749
            :.| |.|..:|....:|          |...:.:|...:.|....::....|...|...|
  Fly   251 KIY-LNWTVNDGNDPIQKFFITLQEAGTPTFTYHKDFINGSHTSYILDHFKPNTTYFLRIVGKNS 314

  Fly   750 ----QTTSYGILSGITSLY--PRTMPLIQSDVVVANGEKEDERDTITLSYTPTP----------- 797
                |.|.|.  .|||:|.  |..:|.:::....|:        |||:.:.|.|
  Fly   315 IGNGQPTQYP--QGITTLSYDPIFIPKVETTGSTAS--------TITIGWNPPPPDLIDYIQYYE 369

  Fly   798 ------------------QSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNIT- 843
                              |.:|:...|.|        ||.|.|.|.:.:|....       ::|
  Fly   370 LIVSESGEVPKVIEEAIYQQNSRNLPYMF--------DKLKTATDYEFRVRACS-------DLTK 419

  Fly   844 ---VW------TVSGGVASLPIQRQDRLYPEPITQLHATNIT-DTEISLRWDLPKGEYNDFDIAY 898
               .|      |...|||:.|....        .|.|..|:| ...|::.||:||.. |...::|
  Fly   420 TCGPWSENVNGTTMDGVATKPTNLS--------IQCHHDNVTRGNSIAINWDVPKTP-NGKVVSY 475

  Fly   899 LTADNLLAQNMTT----------------RNEITISDLRPHRNYTFTVVVRSGTESSVLR---SS 944
            |.  :||...|:|                .::.....:.|:.|||.||       |::.|   :.
  Fly   476 LI--HLLGNPMSTVDREMWGPKIRRIDEPHHKTLYESVSPNTNYTVTV-------SAITRHKKNG 531

  Fly   945 SPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWS------LPS-SEANGVIRQFSIAYTNINN- 1001
            .|.:.|.....:.|..:.|     ...|::|.:..      ||. ||.||.|..:.:....|||
  Fly   532 EPATGSCLMPVSTPDAIGR-----TMWSKVNLDSKYVLKLYLPKISERNGPICCYRLYLVRINND 591

  Fly  1002 ---------LTDAGMQDFESEEAFGVIKNLKPGETYVFKIQA----KTAIGFGPEREYRQTMPIL 1053
                     |..|..|:..|:       |:.....|:.::.:    :..|..|.|:.:.:...|:
  Fly   592 NKELPDPEKLNIATYQEVHSD-------NVTRSSAYIAEMISSKYFRPEIFLGDEKRFSENNDII 649

  Fly  1054 ------------APP---RPATQVVPTE--VYRSSSTIQIRFRK-NYFSDQNGQVRMYTIIVAED 1100
                        ..|   :|....:|.:  :..|.|.:.|...| |.....|  :..:.:.:.|.
  Fly   650 RDNDEICRKCLEGTPFLRKPEIIHIPPQGSLSNSDSELPILSEKDNLIKGAN--LTEHALKILES 712

  Fly  1101 ---DAKNA-SGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYC---- 1157
               |.:|| :..|.|.            ..|::|..|..:.|.:.|. |..:.:::..|:.
  Fly   713 KLRDKRNAVTSDENPI------------LSAVNPNVPLHDSSRDVFD-GEIDINSNYTGFLEIIV 764

  Fly  1158 ---NGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAI-----TVPLTIILVLLV 1214
               |..|.:.:.|         .|..|....:.|||: .:|....::|     .|.|.:|||.:|
  Fly   765 RDRNNALMAYSKY---------FDIITPATEAEPIQS-LNNMDYYLSIGVKAGAVLLGVILVFIV 819

  Fly  1215 TLLFYKRRRNNCRKTTKDSRANDNMSLPDS----------------VIEQNR------PILIKNF 1257
            ..:|:.      :||..:.:..|.::|.||                :...|.      ||...:.
  Fly   820 LWVFHH------KKTKNELQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFDAGPIHRLDL 878

  Fly  1258 AEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDE 1322
            ...|:....|:|:.|..|:|.|.:...|:....:||..|..|||:.:|..||.:|.||..::..:
  Fly   879 ENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQ 943

  Fly  1323 GSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPN 1387
            .:||||||:|.|:...::||..|||:.||.||||||.||.:...|||||...|..:.||.:|||.
  Fly   944 TTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPE 1008

  Fly  1388 ---DTVPVFYGDIKVQILNDSHYADWVMTEFMLCR-----GSEQ--RILRHFHFTTWPDFGVPNP 1442
               ||..  :|||.|:...:....|::.....:.:     |.|:  |.:..:|:.||.||..|..
  Fly  1009 KVFDTKQ--FGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEH 1071

  Fly  1443 PQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKER 1507
            |..:::|:|........::.||:|||||||||:||.:.||.::||:...|.|.|:..|..:|.:|
  Fly  1072 PHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQR 1136

  Fly  1508 VWMVQTEQQYICIHQCLL-------------AVLEGKENIVGPAREMHDNEGYEGQQVQLDENGD 1559
            .::||:.:|||.:::.||             .:....|::     :...|||....:|:.::
  Fly  1137 NFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESL-----KRKPNEGKCKLEVEFEK--- 1193

  Fly  1560 VVATIE--------GHLSHHDLQQAEAEAID-DENAAIL 1589
            ::||.:        |....::::....|.|. |.|..||
  Fly  1194 LLATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVIL 1232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:394996
		fn3	220..304	CDD:394996
		FN3	278..>734	CDD:442628	59/303 (19%)
		FN3	583..671	CDD:238020	19/94 (20%)
		fn3	787..850	CDD:394996	18/101 (18%)
		fn3	866..935	CDD:394996	22/85 (26%)
		fn3	959..1043	CDD:394996	21/104 (20%)
		PTP_tm	1083..1187	CDD:465889	19/114 (17%)
		R3-PTPc	1301..1522	CDD:350396	88/230 (38%)
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046	24/89 (27%)
		Ig_3	134..216	CDD:464046	16/99 (16%)
		fn3	237..321	CDD:394996	15/95 (16%)
		FN3	<300..>524	CDD:442628	58/266 (22%)
		PTPc	892..1155	CDD:214550	99/264 (38%)
		PTPc	1186..1449	CDD:214550	10/50 (20%)