DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and ptpn2a

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_956760.2	Gene:	ptpn2a / 393438	ZFINID:	ZDB-GENE-040426-1196	Length:	392	Species:	Danio rerio

Alignment Length:	313	Identity:	109/313 - (34%)
Similarity:	168/313 - (53%)	Gaps:	42/313 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1267 DSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANY 1331
            ||...:...:.||.:..:::....|..|.|..:||:.::.||||||.||    ::..:|||||:.
Zfish     9 DSSGEWQNLYNELHNQSQERSYKVAKFPENCNRNRYRDVSPYDHSRVKL----ENSENDYINASL 69

  Fly  1332 VPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP---------N 1387
            :....:.|.:|:|||||.:|...||.|.||..|:|::||.|..|||.|||.||||         :
Zfish    70 ITMEEAQRRYILTQGPLKNTCGHFWLMVWEQGSKAVIMLNRVIEKGTEKCAQYWPSKEEQDMNFS 134

  Fly  1388 DT---VPVFYGDIK----VQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQT 1445
            ||   |.:...|:|    :::|           |....:..|.|.:.|||:|.|||||||..|.:
Zfish   135 DTGFMVTLVCEDVKPNYTIRLL-----------ELQNGKTGETRDIYHFHYTAWPDFGVPESPAS 188

  Fly  1446 LVRFVRAFRD--RIGAEQRPIVVHCSAGVGRSGTFITLDR---ILQQINTSDYVDIFGIVYAMRK 1505
            .:.|:...|:  .:|.|..|:|||||||:||||:|..:|.   ::.|.|....|||..::..||:
Zfish   189 FLDFLFKVRESGSLGPENGPVVVHCSAGIGRSGSFSLVDTCLVLMDQRNDFLAVDIQKVLLDMRE 253

  Fly  1506 ERVWMVQTEQQYICIHQCLLAVLEGKENIVGPA---REMHDNEGYEGQQVQLD 1555
            .|:.::||..|   :....:||:||.:.|:|.:   ..:...|.|.|:..:::
Zfish   254 YRMGLIQTPDQ---LRFSYMAVMEGAKLILGDSTLQSSILSPENYIGESDRME 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	98/273 (36%)
		PTPc	1298..1525	CDD:238006	93/247 (38%)
ptpn2a	NP_956760.2	PTPc	11..274	CDD:214550	100/280 (36%)
ptpn2a	NP_956760.2	PTPc	41..274	CDD:238006	95/250 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910