DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and Ptp61F

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	559	Identity:	142/559 - (25%)
Similarity:	229/559 - (40%)	Gaps:	129/559 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1296 NRPKNRFTNILPYDHSRFKLQPVDDDEGS-DYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMC 1359
            ||..||:.::.||||||..|:     .|| ||||||.|....:.|::|:|||||..|...||.|.
  Fly    60 NRGLNRYRDVNPYDHSRIVLK-----RGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMV 119

  Fly  1360 WESNSRAIVMLTRCFEKGREKCDQYWPND-----TVPVFYGDIKVQILNDSHYADWVMTEFML-- 1417
            ||..|||::||.:..||.:.||..||||:     .:.:.:..:.|:::....|.::|...|.|
  Fly   120 WEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTD 184

  Fly  1418 CRGSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDR--IGAEQRPIVVHCSAGVGRSGTFIT 1480
            ....:.|.:..||:|||||||:|:.|...::|::..||.  :..:..|.|||||||:||||||..
  Fly   185 LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCL 249

  Fly  1481 LDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNE 1545
            :|..|..|:.....::..::..:|..|:.::||..|....:|   |::||       .:::||
  Fly   250 VDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQ---AIIEG-------IKKLHD-- 302

  Fly  1546 GYEGQQVQLDENGDVVATIEGHLSHHDLQQAEAEAIDDENAAILHDDQQPLTSSFTGHHT--HMP 1608
                                                     ....|.::||.|:.|..||  .:|
  Fly   303 -----------------------------------------PTFLDAEEPLISNDTETHTLDELP 326

  Fly  1609 P---------TTSMSSFGGG----------GGGHTNVD---APDRXHSVVNQSDNNNSVVIVLVD 1651
            |         ...::...||          ..|..::.   :.|. ::.:||.|..:...:  .|
  Fly   327 PPLPPRVQSLNLPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFINQHDMIHDAEV--AD 389

  Fly  1652 NKPSSMI----CKDSKGGNIDVLESQQQQQQQQQQQPNQGGHNITTIS-----AINGY---NTLQ 1704
            ::|...:    ..||......:|:...:....:.::       ..||:     .:||:   .|..
  Fly   390 SRPLPPLPVRAFNDSDSDEDYLLDDDDEDDTDEDEE-------YETINEHDADPVNGHVPATTQP 447

  Fly  1705 HRRKSQLITFSSSSCDIKNSLSHEYINGSNGSAANG-PPSSGSGSGSGPGSNRASRANVRLSFAE 1768
            |            :.|:..:.....:.......||| .|..|....|.....:..:.|...:..|
  Fly   448 H------------ADDVNANNEKPAVPVDEQHKANGIDPIPGQLPASPENELKRRKRNEYQASLE 500

  Fly  1769 EDVMILPQNHSQQSNHQDDEVFTRRRSLLE-VEIGVEVG 1806
            :.|.  .....|:.|........:|||||. :..||.||
  Fly   501 QKVN--DMKRKQRENEDKQLAAKKRRSLLTYIAAGVVVG 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	89/238 (37%)
		PTPc	1298..1525	CDD:238006	87/236 (37%)
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	90/242 (37%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	88/240 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443509
Domainoid	1	1.000	133	1.000	Domainoid score	I1104
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840