Protein Alignment Ptp10D and PTP-ER

DIOPT Version :9

• Sequence 1: NP_996413.2
• Gene: Ptp10D / 32115
• FlyBaseID: FBgn0004370
• Length: 1990
• Species: Drosophila melanogaster
• Sequence 2: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Alignment Length: 1640
• Identity: 302/1640 - (18%)
• Similarity: 502/1640 - (30%)
• Gaps: 656/1640 - (40%)

  Fly   267 KEGEP--------PGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRD 323
            ||..|        |.|..||.....|..|        .||..|..:|..:  .||..|..:|:
  Fly     9 KENAPIEYPYPQTPRPTHAAPSDTTPLEA--------GEDAESNKSTPYF--TPLEYLQTSFE-- 61

  Fly   324 FITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTV-----------PRSNE-PVAFFDFRDIAE 376
             ..|.:..|....| |..|.:..:..|.|. ||.|:           |.|:: |.....|:.:::
  Fly    62 -FPSPTVEVGGGVP-GFPEHEDQEEEVFTP-RQFTITSPHPAAHVHHPSSSQSPTLGRKFKRLSQ 123

  Fly   377 -PGKTFNVIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEADPASTQDEYRIV 440
             ..::.:..:.|.||:                 ..:.....||.|||......|    ||....:
  Fly   124 YDRRSCSPHINTSSGE-----------------ERVSGRGIDKENTMPKGGSVD----QDLENSL 167

  Fly   441 YHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRPSSPIIEDLK 505
            |                                     :||...::.|.:|          :|..
  Fly   168 Y-------------------------------------LSKSEHNSPTILF----------KDES 185

  Fly   506 SIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVF----AV 566
            |...||..|            .:.||....|.:.......|.|.|.|   .|||:...|    .:
  Fly   186 STTPGLEAS------------RLSYSPKLLSSINNLNVSGSPLNIIN---SAGYKNGNFFRFPEI 235

  Fly   567 SHDLRSEPHAYFQAVYPNPPRNMTIETV---------RSNSVLVHWSPPESGEFTEYSIRYRTDS 622
            .|.::..|                ::||         ||.::.   .|||..:......:.|.:.
  Fly   236 DHVVQDAP----------------MDTVCLEEATRRDRSPALA---EPPEQQQQKSEGRKNRKNK 281

  Fly   623 EQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRN 687
            ....:|          |||:                   |:......:..|.|.:..|:....:.
  Fly   282 NNLTIR----------ITDV-------------------PIKNSSQPSPLPKPKTPTIKSTKEKA 317

  Fly   688 ITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENK-SADDLSTVRVLIGELMPG---VQYKFD 748
            .:|:....|..:.              :...|::|:. |.||:.|     |:..|.   :.:...
  Fly   318 RSLDSAANESELS--------------IVVHNITESHGSCDDMET-----GQSQPSTSVIHHHLH 363

  Fly   749 IQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYT------------------- 794
            :|..:       ::::..::..:.|.:.:||..:...|.:..::.|
  Fly   364 LQQPA-------SAIHSTSLSRLDSHLSLANQRRTPRRKSPGINTTDWLMYHRKQNPYQVQPTHC 421

  Fly   795 -PTPQSSSKFDI-YRFSLGDAEIRDK------------EKLANDTDRK------VTFTGL--VPG 837
             .|.|||...|. ...||||.|::..            ..||..:..|      .:.|.|  :|.
  Fly   422 SSTTQSSLDSDASLTPSLGDFELKSACSVDGGSKFGIGASLAPRSAHKHNQLLHSSSTNLKTLPE 486

  Fly   838 RLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYNDFDI-AYLTA 901
            .|..:...:..||....|.:::....|.|..|...|..|.:...|:   .:|..:...: .:.:.
  Fly   487 CLTLVEFSSSGGGPKESPFKQKSMDLPMPTLQAKTTVSTSSMNLLQ---RRGSNHSLTLNLHSSC 548

  Fly   902 DNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVERFHP 966
            .||:...::            |.||:...::.|       :||..|.|         |...:...
  Fly   549 GNLMNSGLS------------HSNYSLGSILNS-------KSSCNLDA---------GTASQIRA 585

  Fly   967 TDVQPSEINFEWSLPSSEAN--GVIRQ----FSIAYTNINNLTDAG----MQDFESEEAFGVIKN 1021
            ..:..|.:     |.||:.:  |:.|:    .||.....:..|..|    ||..:.::|
  Fly   586 DQLPQSHL-----LGSSQGSRQGLFRRRGSNHSITLKTGHTTTSCGDLNSMQQLQQQQA------ 639

  Fly  1022 LKPGETYVFKIQAKTAIGFG---------PER---EYRQT-------MPILAPPRPATQVVPTEV 1067
            :...|.|........:.|.|         |:|   |.|.:       |..:......|::..|::
  Fly   640 MLSAEKYNRLNMRTNSTGSGSGSGSNVPTPKRGLLERRGSNQSLTLNMGSILGGAAGTEIQMTDI 704

  Fly  1068 YRSSSTI-------QIRFRKNYFSDQN------------GQVRMYTIIVAEDDAKNASGLEMPSW 1113
            .:...|:       |...::.:||.:|            |||..          .:||.|: |:
  Fly   705 VQPKVTVCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCF----------GSASDLQ-PN- 757

  Fly  1114 LDVQSYSVWLPYQAIDPYYPFENRSVEDFTIG-TENCDNHKIGYCNGPLKSGTTYRVKVRAF--- 1174
                               |.::...||..|| |..|             :||...:..|..
  Fly   758 -------------------PQQDSVREDQAIGATCTC-------------AGTVRNIMTRPLSPQ 790

  Fly  1175 TGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTLLF---YKRRRNNCRK------TT 1230
            |.:::|  ..|...||       ::.:.:.||....::.:..:|   |:..||...:      ..
  Fly   791 TTSEEF--KIYLASIQ-------MLQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSNA 846

  Fly  1231 KDSRANDNMSLPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEEL-----KHVGRDQPCTF 1290
            :|.....:|..|.|   ::..:|    |.:..::|     |.::...||     |.:.||....|
  Fly   847 RDVETPTDMVPPSS---EDSELL----ASYQTVVS-----RMAQPIPELKENEQKRIFRDLHKEF 899

  Fly  1291 ADLPCN----------RPKNRFTNILPYDHSRFKLQ-----------------PVDDDEGSDYIN 1328
            .|||.|          :.|||:..|||.::||..|:                 .|...|...|||
  Fly   900 WDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASEDLPYIN 964

  Fly  1329 ANYVPGHNSPRE-FIVTQGPLHSTRDDFWRMCWESNSR--------------------------- 1365
            |||:.|.:...: ::.|||||.:|..:||.|.:::..|
  Fly   965 ANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQ 1029

  Fly  1366 AIVMLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDS----HYADWVMT------------- 1413
            .|||||...|..|:||..|:|.:...:|....|.::...|    .|.|..:|
  Fly  1030 KIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSD 1094

  Fly  1414 -------------------------EFMLCRGS-----EQRILR--------------------- 1427
                                     |.:..:||     ...|:|
  Fly  1095 AIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSA 1159

  Fly  1428 ----------HFHFTTWPDFGVPNPPQTLV--------------RF-----VRAFRDRIGAEQR- 1462
                      |:.:..|||...|....||:              .|     .|:.|:...|.||
  Fly  1160 SYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRL 1224

  Fly  1463 ------------PI-VVHCSAGVGRSGTFITLDRILQQI-------------------------N 1489
                        |: |:|||||:||:|.|..:...::|:                         |
  Fly  1225 EIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHN 1289

  Fly  1490 TSD----------------------------------------YVDIFGIVYAMRKERVWMVQTE 1514
            .:|                                        :||:.|||..:|.:|..|||..
  Fly  1290 PTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNS 1354

  Fly  1515 QQYICIHQCLLAVLE 1529
            :||..||:.:...|:
  Fly  1355 EQYELIHRAICLYLK 1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470	12/44 (27%)
		fn3	315..391	CDD:278470	18/88 (20%)
		FN3	405..494	CDD:238020	13/88 (15%)
		FN3	511..574	CDD:238020	14/66 (21%)
		FN3	583..671	CDD:238020	13/96 (14%)
		fn3	683..753	CDD:278470	11/73 (15%)
		fn3	787..850	CDD:278470	18/103 (17%)
		fn3	866..935	CDD:278470	11/69 (16%)
		fn3	961..1043	CDD:278470	17/100 (17%)
		PTPc	1272..1525	CDD:214550	101/488 (21%)
		PTPc	1298..1525	CDD:238006	91/447 (20%)
PTP-ER	NP_726092.1	Y_phosphatase	916..1364	CDD:278528	91/447 (20%)
		PTPc	917..1364	CDD:238006	91/446 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443525
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030