Protein Alignment Ptp10D and PTPRQ

DIOPT Version :9

• Sequence 1: NP_996413.2
• Gene: Ptp10D / 32115
• FlyBaseID: FBgn0004370
• Length: 1990
• Species: Drosophila melanogaster
• Sequence 2: XP_016874762.1
• Gene: PTPRQ / 374462
• HGNCID: 9679
• Length: 2536
• Species: Homo sapiens
• Alignment Length: 1724
• Identity: 432/1724 - (25%)
• Similarity: 718/1724 - (41%)
• Gaps: 382/1724 - (22%)

  Fly    62 RLDYSPPFGYPEPNTTIASREI--------------GDEIQFSRALPGTKYNFWL-YYTNFTHHD 111
            ||.:|||   .:||..|.:.|:              ..:|......|.|.||..: .||.|.|.:
Human   905 RLKWSPP---EKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGN 966

  Fly   112 WLTWTVTITTA---PD-PPSNLSVQVRSGKNAIILWSPPTQGS-----YTAFKIKVLGLSEASSS 167
            .::..:::.|:   || .|.|::.:..|.....:.:.||:..:     ||.:      |..::.:
Human   967 QVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIY------LKRSNGN 1025

  Fly   168 YNRTFQVNDNTFQHSVKELTPGATY--QVQAYTIY-DGKESVAYTSRNFTTKPNTPGK-FIVWFR 228
            ..||  :|..:...::|.|.....|  :|.|.|:. :|..|...:.......|::|.: |.|...
Human  1026 EERT--INTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQL 1088

  Fly   229 NETTLLVLWQPPY-PAGIYTHYKV----------------SIEPPDANDSVLY------------ 264
            :..|:.:.||||. |.||..:|.|                |:|..|.:.:|.|
Human  1089 SGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGD 1153

  Fly   265 ----------VEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTT--------AQYRTV 311
                      ...||.|..|.:            ::....:|...|.|..|        .||.:|
Human  1154 GKTRSNIISFQTPEGAPSDPPK------------DVYYANLSSSSIILFWTPPSKPNGIIQYYSV 1206

  Fly   312 PLRPLNVTFDRDFI---TSNSFRVLWEAP--KGISEFDKYQVSVATTRRQSTVPRSNEPVAFFDF 371
            ..|..:.||.::|.   .:|.|..:..:.  ..::.|..|...:..:.......:|::.:..:..
Human  1207 YYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTD 1271

  Fly   372 RDIAEPGKTFNVIVKTVSGKV--TSW--PATGD--------VTLRPLPVRNLRSINDDKTNTMII 424
            :||.| |...|:..:::|...  .||  ||..:        :.|:..| |::|        ..::
Human  1272 QDIPE-GFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTP-RHVR--------PPLV 1326

  Fly   425 TWEADPASTQDEYRIVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKK--MESNE 487
            |:|..         |.:..||.:        ||              |.|.:...::|  .::..
Human  1327 TYERS---------IYFDNLEKY--------TD--------------YILKITPSTEKGFSDTYT 1360

  Fly   488 TSIFVVTR----PSSPIIEDLKSI-RMGLNISWKSDV--NSKQEQYEVLYSRNGTSDLRTQKTKE 545
            ..:::.|.    .:||||...|:: ...:.:||...|  |.....|::  :..|.::..:..|.:
Human  1361 AQLYIKTEEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDL--TLQGPNENYSFITSD 1423

  Fly   546 SRLVIKNLQPGAGYELKVFAVSH---DLRSEPHAYF---QAVYPNPPRNMTIETVRSNSVLVHWS 604
            :.::::.|.|...|..  ||.:.   .|......:|   ::|...||:|:|:....|:.|.:.||
Human  1424 NYIILEELSPFTLYSF--FAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWS 1486

  Fly   605 P-PESGEFTE-YSIR-YRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQV-------------N 653
            | |..|...: ||.: :..:::..:.:..|...|||.:..:.....|:|:|             |
Human  1487 PSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSN 1551

  Fly   654 TVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGRVQT- 717
            .|.|..:..||             :::|  :.:.:...|       :|.::||.|......:.|
Human  1552 VVKFTTQESVP-------------DVVQ--NMQCMATSW-------QSVLVKWDPPKKANGIITQ 1594

  Fly   718 ------KNVSENKSADDLSTVRVLIGELMPGVQYKFDIQ-TTSYGILSGIT---SLYPRTMPLIQ 772
                  :|.::....|.:.|    ..:|:....|.|.:: :||.|.....|   |..|.|:|.:.
Human  1595 YMVTVERNSTKVSPQDHMYT----FIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVP 1655

  Fly   773 SDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSL----------GDAEIRDKEKL-----A 822
            :::..:    :.:..:.||::.........|..|:.:.          ...|..:.:|:     |
Human  1656 TNIAFS----DVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEA 1716

  Fly   823 NDTDRKVTFTGLVPGRLY--NITVWTVSG-GVASLPIQRQDRLYPE--PITQLHATNITDTEISL 882
            :.|:.  |..||...|.|  .:...|.:| |.||..|..:....|.  |...:|....:...||:
Human  1717 HLTEE--TVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISI 1779

  Fly   883 RWDLP-------------KGEYND-FDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVR 933
            .|..|             |...|| |:|:::.::.   :|.|    |.|.||.....|:..:...
Human  1780 SWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNE---ENKT----IEIKDLEIFTRYSVVITAF 1837

  Fly   934 SGTESSV-LRSSSPLSASFTTNEAVP-----GRVERFHPTDVQPSEINFEWSLPSSEANGVIRQF 992
            :|..|:. :...|......||.|:.|     ....:..|.:|...::.|   ||.|:.||.|:.:
Human  1838 TGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTF---LPPSQPNGNIQVY 1899

  Fly   993 -SIAY-------TNINNLTDAGMQDFESEEAF--GVIKNLKPGETYVFKIQAKTAIGFGPEREYR 1047
             ::.|       ..|:||:     ..:....|  .:::.||.|.||...:.|..:.|.||:...|
Human  1900 QALVYREDDPTAVQIHNLS-----IIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMR 1959

  Fly  1048 QTMPILAPPRPATQVVPTEVYR-------SSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNA 1105
            .||.|.||.||.|:  ||.:|.       :|:||.||....|:||.:|.::...::|.|..|::.
Human  1960 ITMDIKAPARPKTK--PTPIYDATGKLLVTSTTITIRMPICYYSDDHGPIKNVQVLVTETGAQHD 2022

  Fly  1106 SGLEMPSWLDVQSYSVWLPYQAIDPYYPFE--------------NRSVEDFTIGTENC-----DN 1151
            .  .:..|.|..       :....||:..|              :.:.|.:.||.:|.     :.
Human  2023 G--NVTKWYDAY-------FNKARPYFTNEGFPNPPCTEGKTKFSGNEEIYIIGADNACMIPGNE 2078

  Fly  1152 HKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQT-----DQDNTSLIVAITVPLTIILV 1211
            .||  ||||||....|..|.||.....:|||:.||.|::|     .:....:|:::|:.:..|::
Human  2079 DKI--CNGPLKPKKQYLFKFRATNIMGQFTDSDYSDPVKTLGEGLSERTVEIILSVTLCILSIIL 2141

  Fly  1212 LLVTLLFYKRRRNNCRK----TTKDSRANDNMSLPDSVI-------------------------- 1246
            |...:..:.|.|...::    :.:|:...|.....|.:|
Human  2142 LGTAIFAFARIRQKQKEGGTYSPQDAEIIDTKLKLDQLITVADLELKDERLTRYSSFFFRRKEIF 2206

  Fly  1247 --------EQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFT 1303
                    :..:||..|:|.:|...:..:::.:|.|||.||....:|...|.||||.||.||||.
Human  2207 VIQLLSYRKSIKPISKKSFLQHVEELCTNNNLKFQEEFSELPKFLQDLSSTDADLPWNRAKNRFP 2271

  Fly  1304 NILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIV 1368
            ||.||:::|.||.......|||||||:|:.|:..|.|||.|||||..|..|||||.||:.::.:|
Human  2272 NIKPYNNNRVKLIADASVPGSDYINASYISGYLCPNEFIATQGPLPGTVGDFWRMVWETRAKTLV 2336

  Fly  1369 MLTRCFEKGREKCDQYWPNDTVPV-FYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFT 1432
            |||:||||||.:|.||||.|..|| .:|||.:..|.:....||.:.:..:.|..:...:|..:||
Human  2337 MLTQCFEKGRIRCHQYWPEDNKPVTVFGDIVITKLMEDVQIDWTIRDLKIERHGDCMTVRQCNFT 2401

  Fly  1433 TWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIF 1497
            .||:.|||.....|:.||:..|.....:..|::|||||||||:|.||.||.:.|.||..|:|||:
Human  2402 AWPEHGVPENSAPLIHFVKLVRASRAHDTTPMIVHCSAGVGRTGVFIALDHLTQHINDHDFVDIY 2466

  Fly  1498 GIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK 1531
            |:|..:|.||:.|||...|||.:|||:|.:|..|
Human  2467 GLVAELRSERMCMVQNLAQYIFLHQCILDLLSNK 2500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	19/89 (21%)
		fn3	220..304	CDD:278470	25/123 (20%)
		fn3	315..391	CDD:278470	14/80 (18%)
		FN3	405..494	CDD:238020	13/90 (14%)
		FN3	511..574	CDD:238020	13/67 (19%)
		FN3	583..671	CDD:238020	25/103 (24%)
		fn3	683..753	CDD:278470	12/77 (16%)
		fn3	787..850	CDD:278470	15/80 (19%)
		fn3	866..935	CDD:278470	18/82 (22%)
		fn3	961..1043	CDD:278470	22/91 (24%)
		PTPc	1272..1525	CDD:214550	124/253 (49%)
		PTPc	1298..1525	CDD:238006	110/227 (48%)
PTPRQ	XP_016874762.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920