DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and tnr

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_919364.1	Gene:	tnr / 369191	ZFINID:	ZDB-GENE-030804-1	Length:	1350	Species:	Danio rerio

Alignment Length:	1078	Identity:	238/1078 - (22%)
Similarity:	403/1078 - (37%)	Gaps:	232/1078 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 NETTLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPG-PAQAAFKGLVPGRAYNISV 292
            :|.|:.:.|:.|   .|.|.|.::.||.....    |:.|...|| ......|||.||..||::|
Zfish   333 SENTIDLQWEGP---AILTDYLITYEPTTPGG----VQLEMRVPGNVTNITIKGLNPGLEYNVNV 390

  Fly   293 QTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQS 357
            ..:.::.||.|......|....|..:.|..  |...|..|.|:....:  ||.:::|.
Zfish   391 YAVIDNIISSPMNTLVSTYLSNPDGLLFKS--IMETSVEVQWQPLDYL--FDGWEISF------- 444

  Fly   358 TVPRSNE-------PVAFFDFRDIA-EPGKTFNVIVKTVSGKVTSWPATGDV-TLRPLPVRNL-R 412
             :|:.|:       |.....|.... :||:.:.|.:..:..:..|.|.|..| ||...|::.: |
Zfish   445 -IPKDNDGGMTAQLPSTITSFHQTGLKPGEEYTVNLVALKDQGRSLPVTATVTTLIDGPIQLIVR 508

  Fly   413 SINDDKTNTMIITWEADPASTQDEYRIVYHELETFNGDTSTLTTDRT--RFTLESLLPGRNYSLS 475
            .|:|   ....:.|  .|...:.:..|:.:.|....|..:|.....|  :::|:.|.||..|.:|
Zfish   509 DISD---TVAFVEW--SPPKAKVDQIILRYGLVGVEGPKTTFRLQPTLSQYSLQVLRPGSTYEVS 568

  Fly   476 VQAVSKKMESNETSIFVVTRPSSPIIEDLKSIR------MGLNISW---KSDVNSKQEQYEVLYS 531
            |..|....||...|....|...:|     |::|      :.|.:.|   ::||    |.|.|:||
Zfish   569 VSGVRNGTESGVISTEFTTEIDAP-----KNLRVLSKTSISLELEWDNSEADV----EGYSVVYS 624

  Fly   532 -------------RNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYP 583
                         ||.....:|        .:..|.||..|.:.:.||....:|.|.........
Zfish   625 TLAGDQYDKVIVPRNDGPSTKT--------TLNELMPGTEYGIGISAVLGANQSTPATMNARTGL 681

  Fly   584 NPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRS-TEADITDMTKGEK 647
            :.|.::|:.....|::.:.|...: |....|.:.| |.|......|...:. |...:|.:..|.:
Zfish   682 DVPLDLTVTASTDNTITLLWGTVQ-GPIDHYRVTY-TSSSGVTTELTVPKDVTTTTLTSLQPGTE 744

  Fly   648 YTIQVNTVSFGVESPVPQEVNTTVPPNPVSNI-IQLVDSRNITLEWPKPEGRVESYILKWWPSDN 711
            |||.| ....|.:......::......|::.: ...|.|.::|:.|..|....:::||.:...|:
Zfish   745 YTITV-AAQRGRQQSTAATIDAFTGFRPITQLFFSEVSSDSLTVAWSSPAPPADAFILNYSAQDS 808

  Fly   712 PGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVV 776
            .        .:::.|.|.|..|:.:..|||..:|...: .|.:|   .:||     .|::.|
Zfish   809 S--------EDSEIALDGSKTRITLTGLMPSRRYTATL-VTMHG---NVTS-----KPVVGS--- 853

  Fly   777 VANGEKEDERDTITLSYTPTP-------QSSSKFDIYRFSLGDAEIRDKEKLANDTD-RKVTFTG 833
             .|...:..|| ||:.|....       |..:..|.||.|...::.| .:.:..|:| ...|.|.
Zfish   854 -VNTGMDPPRD-ITVLYVTEESVTITWIQPLALLDYYRMSYQSSKGR-MDSVVIDSDINNYTLTS 915

  Fly   834 LVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYNDFDIA- 897
            |.|...|.|.:..|.|...|..|........:...:|.|.|:|.....|||:.|....:::.:.
Zfish   916 LHPATEYEIKLNAVRGSQESKVITTTVFTAIDMPAELTALNVTPQGALLRWNPPASSVDNYVLTV 980

  Fly   898 ---YLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPG 959
               .:|||..|.:.  .:.|..:|.|.|...|:..:....|.    |.|.:.:|...|..:|
Zfish   981 TRNQVTADTFLVEG--NKQEYQLSQLIPSTTYSVALYATKGP----LTSGTVISNFVTPMDA--- 1036

  Fly   960 RVERFHPTDVQPSEIN-----FEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQD--FESEEAFG 1017
                  |.::..||||     ..|..|.::.:..:..:..|        |...::  .::|:.:.
Zfish  1037 ------PQNLTASEINHRSALISWQPPIADIDNYMLTYKAA--------DGSRKELILDAEDTWI 1087

  Fly  1018 VIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPP-RPATQVVPTEVYRSSSTIQIRFRKN 1081
            .::.|  .||..:.::.:.|.|.       :|..|::.. ....::.||....:...:
Zfish  1088 RLEGL--AETTEYTVRLQVARGL-------ETSVIVSTSFTTGNRLFPTPQNCAQHLL------- 1136

  Fly  1082 YFSDQNGQV--RMYTIIVAEDDAKNASGLEMPSWLDVQSY-------SVWLPYQ----AIDPY-- 1131
                 ||:.  .:|||.|..|.::.           ||.|       ..|:.:|    .:..:
Zfish  1137 -----NGETLGGIYTIYVNRDLSQG-----------VQVYCDMTTDGGGWIVFQRRQNGLTDFSR 1185

  Fly  1132 ----YPFENRSVED-FTIGTENCDNHKIG------------------YCN------GPLKSGTTY 1167
                |.....|:|| |.:|.:|.  |||.                  |.|      |..||  .|
Zfish  1186 KWTDYKIGFGSLEDEFWLGLDNI--HKIAAQGRYELRIDMKDGQESVYANYDRFSIGDSKS--LY 1246

  Fly  1168 RVKVRAFTG-ADKFTDTAYSFPIQT-DQDNTSLIVAIT 1203
            ::::..::| |........|.|..| |:||.   :|:|
Zfish  1247 KLRIGEYSGTAGDSLSYHQSRPFSTKDKDND---IAVT 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470	23/75 (31%)
		fn3	315..391	CDD:278470	16/83 (19%)
		FN3	405..494	CDD:238020	22/91 (24%)
		FN3	511..574	CDD:238020	19/78 (24%)
		FN3	583..671	CDD:238020	18/88 (20%)
		fn3	683..753	CDD:278470	16/69 (23%)
		fn3	787..850	CDD:278470	19/70 (27%)
		fn3	866..935	CDD:278470	17/72 (24%)
		fn3	961..1043	CDD:278470	15/88 (17%)
		PTPc	1272..1525	CDD:214550
		PTPc	1298..1525	CDD:238006
tnr	NP_919364.1	EGF_2	199..225	CDD:285248
		EB	234..283	CDD:279949
		EGF_2	294..318	CDD:285248
		fn3	323..401	CDD:278470	23/74 (31%)
		fn3	411..490	CDD:278470	17/90 (19%)
		fn3	500..579	CDD:278470	20/83 (24%)
		FN3	590..674	CDD:238020	23/100 (23%)
		fn3	682..754	CDD:278470	17/74 (23%)
		fn3	771..849	CDD:278470	21/94 (22%)
		FN3	859..935	CDD:214495	21/77 (27%)
		fn3	949..1019	CDD:278470	17/71 (24%)
		fn3	1035..1103	CDD:278470	14/86 (16%)
		FReD	1126..1336	CDD:238040	40/186 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12382
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000