DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptprt

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_038961451.1	Gene:	Ptprt / 362263	RGDID:	1309653	Length:	1504	Species:	Rattus norvegicus

Alignment Length:	1399	Identity:	346/1399 - (24%)
Similarity:	521/1399 - (37%)	Gaps:	423/1399 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   547 RLVIKNLQ----PGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPP- 606
            ||::..||    ||||.:......|.|.......|..|:..|   ..|.|.:.:      |..|
  Rat    13 RLLLLGLQRPPLPGAGAQSAAGGCSFDEHYSNCGYSVALGTN---GFTWEQINT------WEKPM 68

  Fly   607 -----ESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQE 666
                 .:|.|...:...|...::..:.||:::..:....|.   ..|....:..|.|..: |..:
  Rat    69 LDPAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDF---HYYFSSRDRSSPGALN-VYVK 129

  Fly   667 VNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWP------------SDNPGRVQTKN 719
            ||.....|||.|:     |..:|..|.|.|..:.::    ||            ..:||.:....
  Rat   130 VNGGPQGNPVWNV-----SGVVTEGWVKAELAISTF----WPHFYQVIFESVSLKGHPGYIAVDE 185

  Fly   720 VSE-----NKSAD--DLSTVRVLIGELMPGVQYKFDIQTTSYGILSG----------ITSLYPRT 767
            |..     .|:..  .|..|.|.:|            |..::..::|          :.....|.
  Rat   186 VRVLAHPCRKAPHFLRLQNVEVNVG------------QNATFQCIAGGKWSQHDKLWLQQWNGRD 238

  Fly   768 MPLIQSDVVVANGEKEDERDTITLSYTPTPQSS-SKFD-IYRFSLGD-----AEIRDKEK----- 820
            ..|:.:.||      ...|.:.|:|...|.|.| ||:. :.|...|.     ||:..||.
  Rat   239 TALMVTRVV------NHRRFSATVSVADTSQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIA 297

  Fly   821 ---------------------------LANDTDRKVTFTG-----------------LVPGRLYN 841
                                       :..:.:.:.| ||                 |.|...|.
  Rat   298 PPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTT-TGTWAETHIVDSPNYKLWHLDPDVEYE 361

  Fly   842 ITVWTVSGGVASL---------------PIQ------------RQDRLYPEP----ITQLHATNI 875
            |.|.....|....               |:.            ||..|..||    :|:.|:.|:
  Rat   362 IRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSYNL 426

  Fly   876 TDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVV-----RSG 935
            |   :..::...:.:|...::            :.|.:..|:..|||.......:::     |..
  Rat   427 T---VQYQYVFNQQQYEAEEV------------IQTSSHYTLRGLRPFMTIRLRLLLSNPEGRME 476

  Fly   936 TESSVLRSSSPLSASFTTNEAVPGRVERFHPTD-VQ--PSE--INFEWSLPSSEANGVIRQFSIA 995
            :|..|::          |.|.|||.|    |.: :|  |.|  |..:|. |.:|.||||..:.|.
  Rat   477 SEELVVQ----------TEEDVPGAV----PLESIQGGPFEEKIYIQWK-PPNETNGVITLYEIN 526

  Fly   996 YTNINNLTDAGMQDFESE---------EAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMP 1051
            |..:.:|..:.  |..|:         |...:...|.||.||.|.|:|.||.||||....|....
  Rat   527 YKAVGSLDPSA--DLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATK 589

  Fly  1052 ILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAED---DAKNASGLEMPSW 1113
            |.||..|... ..:.:..:.:||.:..:.  ...:...|.:|.::|.|:   .::.|:.:
  Rat   590 ISAPSMPEYD-ADSPLNETDTTITVMLKP--AQSRGAPVSVYQLVVKEERLQKSRRAADI----- 646

  Fly  1114 LDVQSYSVWLPYQ---AIDPYYPF------ENRSV-EDFTIGTENCDNHKIGYCN---GPLKSGT 1165
              ::.:||.:.|:   .:|..:.|      .|..| :.||:|.....|   ||.|   .||||.:
  Rat   647 --IECFSVPVSYRNASNLDSLHYFAAELKPSNLPVTQPFTVGDNKTYN---GYWNPPLSPLKSYS 706

  Fly  1166 TY----------------RVKVRAFTGADKFT------------DTAYSFPIQTDQ--DNTSLIV 1200
            .|                |:..:|..|:.:.|            .|..|..::.::  |||..:.
  Rat   707 IYFQALSKANGETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMA 771

  Fly  1201 AITVPLTI-ILVLLVTLLFYKRRRN--------NCRK-------------------------TTK 1231
            .:...|.: |::||..:|..|||||        :.||                         |||
  Rat   772 GVIAGLLMFIIILLGVMLTIKRRRNAYSYSYYLSQRKLAKKQKETQSGAQREMGPVASTDKPTTK 836

  Fly  1232 -DSRAND-------------------NMSLPDSVI-----------------EQNRP-ILIKNFA 1258
             .:..||                   .:|.|...|                 :|.:| |.:.:..
  Rat   837 LSTNRNDEGFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLL 901

  Fly  1259 EHYRLMSADSDFRFSEEFE--------------ELKHVGRDQPCTF--ADLPCNRPKNRFTNILP 1307
            :|...|.....:.|.||:|              ||:.:...|..::  |....||.|||:.||:.
  Rat   902 QHITQMKRGQGYGFKEEYEDSYKTTNFGGILEQELQALPEGQTASWDTAKEDENRNKNRYGNIIS 966

  Fly  1308 YDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTR 1372
            |||||.:|..:|.|..||||||||:.|::.||.:|.||||:..|..|||||.|:.||.:|||:|.
  Rat   967 YDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTN 1031

  Fly  1373 CFEKGRE--------------------KCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFML 1417
            ..|.||.                    ||.:|||:||  ..||||||.::.....|::|:..|.:
  Rat  1032 LVEVGRHPAEHTVGTATLGRAASPGMVKCVRYWPDDT--EVYGDIKVTLIETEPLAEYVIRTFTV 1094

  Fly  1418 CRGS--EQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFIT 1480
            .:..  |.|.||.||||:|||.|||.....|:.|||..:.....|..|||||||||.||:|.||.
  Rat  1095 QKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIA 1159

  Fly  1481 LDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLL-AVLEGKENI-VGPAREMHD 1543
            :|.:|........||||..|..:|.:||.:||||:||:.:|..:| |.|.|...| |...|.::.
  Rat  1160 IDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYY 1224

  Fly  1544 NEGYEGQQVQLDENGDVVATIE-------------GHL-SHHD----------------LQQAEA 1578
            |......|....:..|...|:.             |.| .:||                |...:.
  Rat  1225 NISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG 1289

  Fly  1579 EAIDDENAAILHDDQQPLTSSFTGHHTHMPPTTS 1612
            |:.:..|||::...:||.....|.|  .:|.|.:
  Rat  1290 ESSNYINAALMDSHKQPAAFVVTQH--PLPNTVA 1321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020	10/30 (33%)
		FN3	583..671	CDD:238020	17/93 (18%)
		fn3	683..753	CDD:278470	16/88 (18%)
		fn3	787..850	CDD:278470	21/118 (18%)
		fn3	866..935	CDD:278470	12/77 (16%)
		fn3	961..1043	CDD:278470	32/95 (34%)
		PTPc	1272..1525	CDD:214550	121/290 (42%)
		PTPc	1298..1525	CDD:238006	111/248 (45%)
Ptprt	XP_038961451.1	MAM	36..193	CDD:214533	35/178 (20%)
		Ig	200..285	CDD:416386	20/102 (20%)
		fn3	298..364	CDD:394996	7/66 (11%)
		FN3	394..484	CDD:238020	18/114 (16%)
		fn3	506..581	CDD:394996	27/77 (35%)
		R-PTPc-T-1	953..1209	CDD:350478	115/257 (45%)
		R-PTPc-T-2	1294..1499	CDD:350482	9/30 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11776
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910