DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and Lar

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:1971 Identity:436/1971 - (22%)
Similarity:715/1971 - (36%) Gaps:587/1971 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 QLSKAT-TRIRLKRQKAVPQHRWLWSLAFLAAFTLKDVRCADLAISIPNNPGLDDGASYRLDYSP 67
            |:|:.| |.:||:           ||.                       .|.:|...|.:.|.|
  Fly   329 QISEVTATSVRLE-----------WSY-----------------------KGPEDLQYYVIQYKP 359

  Fly    68 PFGYPEPNTTIASREIGDEIQF---SRAL-PGTKYNFWLYYTNFTHHDWLTWTVTITTA------ 122
                  .|...|..||...|..   .||| |.|:|.|::...|.......:...|.||.      
  Fly   360 ------KNANQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFSFGG 418

  Fly   123 ---PDPPSNLSVQVRSGKNAIILWSPP--TQGSYTAFKI-KVLGLSEASSSYNRTFQVNDNTFQH 181
               ...|.|:.|:..|....:|.|.||  ..|..|.:|: .....::..:|:|.  |:.||:...
  Fly   419 TKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQPEASWNS--QMVDNSELT 481

  Fly   182 SVKELTPGATY--QVQAYT-IYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPYPA 243
            :|.||||.|.|  :||||| :..|..|.....:.....|:.|..|......||.:.:.|..|   
  Fly   482 TVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKP--- 543

  Fly   244 GIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQY 308
               ||         :::::::.|.........||..|.:....||.:       |.: .|.|..|
  Fly   544 ---TH---------SSENIVHYELYWNDTYANQAHHKRISNSEAYTL-------DGL-YPDTLYY 588

  Fly   309 RTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAFFDFRD 373
                                    :|.|              |.::|                  
  Fly   589 ------------------------IWLA--------------ARSQR------------------ 597

  Fly   374 IAEPGKTFNVIVKTVSGKVTSWPATGDVTLRPLPV---------RNLRSINDDKTNTMIITWEAD 429
                            |:..:.|        |:||         ||:.:|....| |:.::|...
  Fly   598 ----------------GEGATTP--------PIPVRTKQYGAPPRNITAIATSST-TISLSWLPP 637

  Fly   430 PASTQD----EYRIVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSI 490
            |....:    .|::.:.|:...:.:.:|:|.:.|...|:.|.....|.:.|.|        .||:
  Fly   638 PVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTEYKIWVLA--------GTSV 694

  Fly   491 FVVTRPSSPIIEDLKSIRMGLNISWKSDVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQP 555
            ....| |.|||                                    ||||:.            
  Fly   695 GDGPR-SHPII------------------------------------LRTQED------------ 710

  Fly   556 GAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNMTIETVRSNSVLVHWSPP----ESGEFTEYSI 616
                                      .|..|:::....:.|.|:.|.|.||    .:|....|.|
  Fly   711 --------------------------VPGDPQDVKATPLNSTSIHVSWKPPLEKDRNGIIRGYHI 749

  Fly   617 RYR--TDSEQQWVRLP----SVRSTEADITDMTKGEKYTIQV----------NTVSFGVESP--V 663
            ..:  .|..:.::..|    .|.:.|.::|.:....||:|||          .:.:..|::|  |
  Fly   750 HAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGV 814

  Fly   664 PQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPE---GRVESYILKWWPSDN-------PGRVQTK 718
            |      |.|.....|::.....:|.|||.:|.   |.:..|.|:|...|.       .|...||
  Fly   815 P------VRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEMLSGPQMTK 873

  Fly   719 NVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKE 783
            ...:|               |..||:|:|.:..:::      ..:...|:.:.|:......|...
  Fly   874 KRFDN---------------LERGVEYEFRVAGSNH------IGIGQETVKIFQTPEGTPGGPPS 917

  Fly   784 D------ERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDK-------EKLANDTDRKVTFTGLV 835
            :      ..|.:.:::.|..:......|.|:   |.:...|       |:  |.|.||..||.|.
  Fly   918 NITIRFQTPDVLCVTWDPPTREHRNGIITRY---DVQFHKKIDHGLGSER--NMTLRKAVFTNLE 977

  Fly   836 PGR--LYNITVWTVSG-GVAS--LPIQRQDRLYPEPIT-QLHATNITDTEISLRWDLP---KGEY 891
            ...  ::.:..:|..| |..|  |.::.:..:...|:: |..||:....||   |..|   :|:.
  Fly   978 ENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEI---WWEPVTSRGKL 1039

  Fly   892 NDFDIAY-LTA----DNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASF 951
            ..:.|.| :||    |:...:.:.......:.:|.....|...:..|  .::.:.|.|..::...
  Fly  1040 LGYKIFYTMTAVEDLDDWQTKTVGLTESADLVNLEKFAQYAVAIAAR--FKNGLGRLSEKVTVRI 1102

  Fly   952 TTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNIN-NLTDAGMQDFESEEA 1015
            .. |.||..: |.|  ||....:...||.|            |..|.:| .::...|:.|...:.
  Fly  1103 KP-EDVPLNL-RAH--DVSTHSMTLSWSPP------------IRLTPVNYKISFDAMKVFVDSQG 1151

  Fly  1016 FG-------------------VIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPI-----LAPP 1056
            |.                   .|..|.|..||...:.|     ...:..||....|     :|.|
  Fly  1152 FSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSA-----IPSDYSYRPPTKITVTTQMAAP 1211

  Fly  1057 RPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGL------------- 1108
            :|   :|..:.|...:..:|.......|::.|.:..|.::|..:|..|...:             
  Fly  1212 QP---MVKPDFYGVVNGEEILVILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFLTDDLLPGR 1273

  Fly  1109 ---EMPSWLDVQSYSVWLPYQAIDPYYPFENRSVE-DFTIGTENCDNHKIGYCNGPLKSGTTYRV 1169
               |.|:          .||.|.    .|..||:. .|.:|:.: |.|  .:.|..|:....||:
  Fly  1274 NKPERPN----------APYIAA----KFPQRSIPFTFHLGSGD-DYH--NFTNRKLEREKRYRI 1321

  Fly  1170 KVRAFTGADK---FTDTAYS----------------------FP------IQTDQDNTSL---IV 1200
            .|||.....:   :|.:.:|                      :|      :..::|...:   ::
  Fly  1322 FVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVL 1386

  Fly  1201 AITVPLTIILVLLVTLLFYKRRRNNCR-----KTTKDSRAND----------------NMSLPDS 1244
            .:.|...|:...|:.|...||||..|:     ..|:...|.|                |...|..
  Fly  1387 PLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGM 1451

  Fly  1245 VIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYD 1309
            :  .:.||.|..||.|...:.::.:.:||:|:|.:: .|:......::|..|:.|||:.|:..||
  Fly  1452 I--SHPPIPISEFANHIERLKSNDNQKFSQEYESIE-PGQQFTWDNSNLEHNKSKNRYANVTAYD 1513

  Fly  1310 HSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCF 1374
            |||.:|..|:...|||||||||..|:.....::.|||||..|..||||||||..:..|||:||..
  Fly  1514 HSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLE 1578

  Fly  1375 EKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRG--SEQRILRHFHFTTWPDF 1437
            |:.|.|||||||...... ||.|.|.|......|.:.:..|.|||.  :::|.::...||.|||.
  Fly  1579 ERTRIKCDQYWPTRGTET-YGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDH 1642

  Fly  1438 GVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYA 1502
            |||:.|...::|:|..|.....|..|::|||||||||:|.:|.:|.:|:::.....:||:|.|..
  Fly  1643 GVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTC 1707

  Fly  1503 MRKERVWMVQTEQQYICIHQCLL-AVLEGKENIVGPAREMHDNEGYEGQQVQLDENGDVVATIEG 1566
            :|.:|.:|||||.|||.||..:| |::.|...:  |||.:|.:.    |::.:.|.|:.::.:| 
  Fly  1708 LRAQRNYMVQTEDQYIFIHDAILEAIICGVTEV--PARNLHTHL----QKLLITEPGETISGME- 1765

  Fly  1567 HLSHHDLQQAEAEAIDDENAAILHDDQQPLTSSF-TGHH----THMPPTTSMSSF-----GGGGG 1621
                     .|.:.:.:    :..|..:.:|::. ...|    .|:.|..|...:     |..|.
  Fly  1766 ---------VEFKKLSN----VKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGS 1817

  Fly  1622 GHTNVDAPD----RXHSVVNQS--------------DNNNSVVIVLVDNKPSSMICKDSKGGNID 1668
            .:.|....|    | ..:..|.              ::|:::|::|...|               
  Fly  1818 DYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLK--------------- 1867

  Fly  1669 VLESQQQQQQQQQQQPNQGG--HNITTISAINGYNTLQHRRKSQLITFSSSSCDIKNSLSH---- 1727
                :..:::..|..|::..  :....:..|..||..|::.:...:|      |.::..|.    
  Fly  1868 ----EMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVT------DARDGSSRTVRQ 1922

  Fly  1728 -EYINGSNGSAANGPPSSGSG 1747
             ::|:...    .|.|.||.|
  Fly  1923 FQFIDWPE----QGVPKSGEG 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 29/86 (34%)
fn3 220..304 CDD:278470 15/83 (18%)
fn3 315..391 CDD:278470 4/75 (5%)
FN3 405..494 CDD:238020 22/101 (22%)
FN3 511..574 CDD:238020 4/62 (6%)
FN3 583..671 CDD:238020 25/109 (23%)
fn3 683..753 CDD:278470 19/79 (24%)
fn3 787..850 CDD:278470 16/72 (22%)
fn3 866..935 CDD:278470 17/77 (22%)
fn3 961..1043 CDD:278470 19/101 (19%)
PTPc 1272..1525 CDD:214550 110/254 (43%)
PTPc 1298..1525 CDD:238006 103/228 (45%)
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470 26/114 (23%)
FN3 423..514 CDD:238020 30/92 (33%)
FN3 520..610 CDD:238020 28/192 (15%)
FN3 616..707 CDD:238020 25/136 (18%)
FN3 712..810 CDD:238020 22/97 (23%)
FN3 832..907 CDD:238020 20/95 (21%)
FN3 914..1005 CDD:238020 20/95 (21%)
FN3 1012..1101 CDD:238020 19/93 (20%)
fn3 1106..1198 CDD:278470 22/111 (20%)
PTPc 1476..1731 CDD:214550 110/256 (43%)
PTPc 1503..1731 CDD:238006 103/228 (45%)
PTPc 1763..2022 CDD:214550 33/220 (15%)
PTPc 1791..2022 CDD:238006 29/178 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45443517
Domainoid 1 1.000 163 1.000 Domainoid score I1235
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm2866
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR19134
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
65.970

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