DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and Ptpmeg2

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	883	Identity:	206/883 - (23%)
Similarity:	328/883 - (37%)	Gaps:	279/883 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   790 TLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVS------ 848
            |.:.:|:..|||                    |:.|...:   .:||.:|..:.|...:
  Fly    57 TTATSPSTSSSS--------------------ASSTQNLI---AVVPPQLQQLQVQLPAPGGGGG 98

  Fly   849 --------GGVASLPIQRQDRLYPEPITQLHATNITDTEI--SLRWDLPKGEYNDFDIAYLTADN 903
                    ||..:.|::|            |.::.|..:.  :.::|:|:            |.:
  Fly    99 AGAGGGGGGGGGAAPVRR------------HISHTTAVKFLYARKFDIPR------------AVS 139

  Fly   904 LLAQNMTTRNEITI----SDLRPHRNY----TFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGR 960
            |..|:...|.:..:    .|:.|.|:.    .||::       ....||....|.||.|...|..
  Fly   140 LYEQHEQIRLKEYLYNIDPDVEPLRSELQTGKFTIL-------PARTSSGAAIALFTANRHSPLS 197

  Fly   961 VERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPG 1025
            |.  |.|.:|                |::.|.           |:.:||.|::.|         |
  Fly   198 VS--HTTTLQ----------------GIVYQL-----------DSALQDSETQRA---------G 224

  Fly  1026 ETYVFKIQAKTAIGFGPEREYRQTMPILA------PPR---------PATQVVPTEVYRSSSTIQ 1075
            ..:::.:.......|    :|..:..||.      |.|         |.....|.::.|  ..::
  Fly   225 LVFIYDMSGSKYSNF----DYDLSQKILTLLKGGYPARLKKVLIVTAPLWFKAPFKILR--LFVR 283

  Fly  1076 IRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVE 1140
            .:.|:..|:....|:.::.       .:.|..:.:...|:| .::.||    :.......||..|
  Fly   284 EKLRERVFTVSVPQLALHV-------PRKALPIHLGGTLEV-DHATWL----LSCRQSMTNREDE 336

  Fly  1141 DF-----------------------TIGTEN----------CDNHKIGYCN----------GPLK 1162
            ..                       |.|||.          ...|::|..|          ||..
  Fly   337 LLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPAG 401

  Fly  1163 SGTTYRVKVRAFTGADKFTDTAYSFPIQ---------TDQDNTSLIVAITV--PLTIILVLLVTL 1216
            |.:.     .|.|.|...|:...:..|.         .:..::|...|.||  ||        .|
  Fly   402 SASG-----GATTAASAATEPNENITINGLSPSHRQAANNSSSSSSSAATVANPL--------KL 453

  Fly  1217 LFYKRRRNNCRKT--------------------------TKDSRANDNMSLPDSVIEQN---RPI 1252
            .......||...|                          ...|.|:...|..||:..|.   :||
  Fly   454 NTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAGQEGDPKPI 518

  Fly  1253 -----LIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHSR 1312
                 ::|....|..:          :|:.::::...:.....|.:..|..|||:|::|.|||||
  Fly   519 DQIVQMVKQRGRHGLI----------KEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSR 573

  Fly  1313 FKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKG 1377
            ..|...|.||.|||||||:|.|:.....:|.|||||..|..|||||.||.:...|||.||..|:|
  Fly   574 VVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERG 638

  Fly  1378 REKCDQYW-PNDTVPVFYGDIKVQILNDSHYADWVMTEFML--CRGSEQRILRHFHFTTWPDFGV 1439
            |.||.||| |.:...:.:||..|:.::.....|:::....|  .:..|.|.:.|:.||:|||:||
  Fly   639 RVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGV 703

  Fly  1440 PNPPQTLVRFVRAFRDR-------IG------AEQRPIVVHCSAGVGRSGTFITLDRILQQINTS 1491
            |:....::.|::..|::       :|      ....|||||||||:||:|||||||..:.::...
  Fly   704 PSSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDV 768

  Fly  1492 DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE 1529
            ...||.|.|..:|.:|.:.:|...||:..|   ||::|
  Fly   769 GTADIRGTVEKIRSQRAYSIQMPDQYVFCH---LALIE 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470	11/73 (15%)
		fn3	866..935	CDD:278470	13/78 (17%)
		fn3	961..1043	CDD:278470	13/81 (16%)
		PTPc	1272..1525	CDD:214550	101/268 (38%)
		PTPc	1298..1525	CDD:238006	98/242 (40%)
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	7/53 (13%)
		SEC14	170..314	CDD:238099	34/201 (17%)
		Y_phosphatase	557..803	CDD:278528	101/248 (41%)
		PTPc	559..803	CDD:238006	100/246 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443511
Domainoid	1	1.000	163	1.000	Domainoid score	I1235
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2866
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.940