DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and Ptprb

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001359063.1	Gene:	Ptprb / 314843	RGDID:	1305922	Length:	2000	Species:	Rattus norvegicus

Alignment Length:	1680	Identity:	507/1680 - (30%)
Similarity:	780/1680 - (46%)	Gaps:	263/1680 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSKATTRIRLKRQKAVPQHRWLWSLAFLAAFTLKDVRC---------ADLAISIPNNPGLDDGAS 60
            :.|..|...|:..:.:|..::...:...:.......||         ..|.|...|...|  |.:
  Rat   425 VGKEETHFALEGLELIPGRQYEVEVIVESGNLRNSERCQGRTVPLAVLQLRIKQANETSL--GIT 487

  Fly    61 YRLDYSPPFGYPEPNT-TIASREI----------GDEIQFSRALPGTKYNFWLYYTNFTHHDWLT 114
            :|    .|.|..|..| ::..||:          ..|..|:..:||..|.
  Rat   488 WR----APLGEWEKYTISLMDRELFVIHKSLSKDAKEYTFTNLMPGRNYK--------------- 533

  Fly   115 WTVTITT-APDPPSNLSVQVRSGKNAIILWSPPTQGSYTAF---KIKVLG---------LSEASS 166
              .|:|: :.|...:.|:|.|:....:.......||..::.   ..|.||         :.|...
  Rat   534 --ATVTSMSGDLKQSASIQGRTVPAQVTDLEVSNQGMTSSLFTNWTKALGDVEFYQVLLIHENVV 596

  Fly   167 SYNRTFQVNDNTFQHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNET 231
            ..|.:  |:.::..:|.:.|..|:.|.|...|:..|..|....:...|...:..|..:.......
  Rat   597 VKNES--VSSDSSWYSFRALRSGSLYSVVVTTVSGGIPSRQVVAEGRTVPSSVSGVTVNNSGRND 659

  Fly   232 TLLVLWQPPYPAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQAAFKGLVPGRAYNISVQTMS 296
            .|.|.|.|. |..:: ||.|::    ::||.: |:........::.:|..|.|||.||:::.|.|
  Rat   660 YLSVSWLPA-PGEVH-HYVVTL----SHDSKV-VQSLITAKFVSECSFSSLTPGRLYNVTITTKS 717

  Fly   297 EDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFR-----VLWEAPKGISEFDKYQVSVATTRRQ 356
            .:..| .:.::.||||.:...::      .|||.|     |.|....|  :||.|:|::  ..|.
  Rat   718 GNYES-HSFSEERTVPDKVQGIS------VSNSARSDYLKVSWVHATG--DFDHYEVTI--KNRD 771

  Fly   357 S-----TVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKV-TSWPATGDVTLRPLPVRNLRSIN 415
            |     ::|:|.....|...    .||:.:::.|.|.||:. .|...||...  |.||:||..:|
  Rat   772 SFIQTKSIPKSENECVFARL----VPGRLYSITVTTKSGQYEASEQGTGRTI--PEPVKNLTLLN 830

  Fly   416 DDKTNTMIITW-EADPASTQDEYRIVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAV 479
             ..|..:.:|| .|:....|.|.::::::::.|  ....|....|.:...:|.|||:|.:.|..:
  Rat   831 -RSTEDLHVTWSRANGDVDQYEVQLLFNDMKVF--PPIYLVNTATEYQFSALTPGRHYKILVLTI 892

  Fly   480 SKKMESNETSIFV--VTRPSSPIIEDLKSIRMGLN-------ISWK---SDVNSKQEQYEVLYSR 532
            |..::.   ..|:  :|.||:     :|:|.:..|       ::|.   .||:|    |.|
  Rat   893 SGDVQQ---PAFIEGLTVPST-----VKNIHISANGATDRLTVTWSPGGGDVDS----YVV---- 941

  Fly   533 NGTSDLRTQKTKESRLVIKN--------LQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPRNM 589
               |..|..:..||..:.|:        |:.||.|.:.:.:||..||::.....|.|..:....:
  Rat   942 ---SAFRQDEKVESHTLPKHGSEHTFHRLEAGATYRIAIVSVSGSLRNQIDVLGQTVPASVHGVV 1003

  Fly   590 TIETVRSNSVLVHWSPPESGEFTEYSIRYRTD--------SEQQWVRLPSVRSTEADITDMTKGE 646
            ......|||:.|.|. ...|....|.|...::        ||...|:       :....|:|.|:
  Rat  1004 ADNAYSSNSLTVSWQ-KALGMAERYDILLLSENGVLLSNTSEPATVK-------QHKFEDLTPGK 1060

  Fly   647 KYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNI-IQLVDSRNITLEWPKPEGRVESYILKWWPSD 710
            ||.:|:.|||.|:.|...:....|||. .|:|: |....||:::..|...||.:..|.:..:..|
  Rat  1061 KYKMQILTVSGGLFSKEVETEGRTVPA-AVTNLRITENSSRHLSFSWTASEGELSWYNIFLYNPD 1124

  Fly   711 NPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQSDV 775
                   |.:.|....|.| ........|:.|..||..|.|.| |.||..:.::.||:|...:.:
  Rat  1125 -------KTLQERAQVDPL-VQSFSFQNLLQGRMYKMVIVTHS-GELSNESFIFGRTVPAAVNHL 1180

  Fly   776 VVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVT---FTGLVPG 837
               .|...:..|::..|::|   :|..||.|...|.:.....||   |..::.||   |.||:||
  Rat  1181 ---KGSNRNMTDSLWFSWSP---ASGDFDFYELILYNPNGTKKE---NWREKDVTEWRFQGLIPG 1236

  Fly   838 RLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLPKG--EYNDFDIAYLT 900
            |.|.:.|.|.||.::: .:..:.|..|.|.:.|...::.:|.:::.|..|..  :||||::.:|.
  Rat  1237 RKYTLYVVTHSGDLSN-KVTGEGRTAPSPPSLLSFADVANTSLAITWKGPPDWTDYNDFELQWLP 1300

  Fly   901 ADNLLAQNMTTRNEI---TISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPGRVE 962
            .|.|...|..:..:.   .::.|||.|:|.|:|...||  .|....|.|:|.|..|.   |.:::
  Rat  1301 GDALTVFNPYSSKKSEGRIVNGLRPGRSYQFSVKTVSG--DSWKTYSKPISGSVRTK---PDKIQ 1360

  Fly   963 RFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGET 1027
            ..|......:.|...|..|.|:.:|    :||....::.......:..|.|::...|..|.|...
  Rat  1361 NLHCRPQNSTAIACSWIPPDSDFDG----YSIECRKMDTQEIEFSRKLEKEKSLLNIMMLVPHRR 1421

  Fly  1028 YVFKIQAKTAIGFGPEREYRQTMPIL---APPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQ 1089
            |:..|:.::| |...|.....|:.::   .||.|..:|...:|..|.|:|......::|||.||.
  Rat  1422 YLVSIKVQSA-GVTSEVVEDSTITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGA 1485

  Fly  1090 VRMYTIIVAEDDAKNASGLE----MPSWLDVQSYSVWLPYQAIDPYY-------PFENRSVEDFT 1143
            |:.:.::|.|.|:.:....|    :||:|:.:..:....||.  .|:       |..:||.:.|.
  Rat  1486 VKYFAVVVREADSMDELRPEQQHPLPSYLEYRHNASIRVYQT--NYFASKCAESPDPDRSSKSFN 1548

  Fly  1144 I--GTE------NCDNHKIGYCNGPLKSGTTYRVKVRAFT-----GADKFT-----DTAYSFPIQ 1190
            |  |.|      .||..:..:|:||||..|.||:.:||||     |..:||     ||.:|.||.
  Rat  1549 IKLGGEMDSLGGKCDPSQQKFCDGPLKPHTAYRISIRAFTQLFDEGLKEFTKPLYSDTFFSMPIT 1613

  Fly  1191 TDQDNT-SLIVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMSL------PDSV--- 1245
            |:.:.. .:|..::..|.:|.:|:..:.|:     .||:....||...:..|      |.||
  Rat  1614 TESEPLFGVIEGVSAGLFLIGMLVALVAFF-----ICRQKASHSRERSSARLSIRRDRPLSVHLN 1673

  Fly  1246 --IEQNR----PILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTN 1304
              .:.||    ||.|..|..|:..:.|||::..|:|:|:||.|||.|.|..|.||.||.|||:.|
  Rat  1674 LGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEDLKDVGRSQSCDIALLPENRGKNRYNN 1738

  Fly  1305 ILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVM 1369
            |||||.||.||..||||..||||||:|:||:|..||:|.|||||..|:||||:|.||.|...|||
  Rat  1739 ILPYDASRVKLCNVDDDPCSDYINASYIPGNNFRREYIATQGPLPGTKDDFWKMAWEQNVHNIVM 1803

  Fly  1370 LTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQ----RILRHFH 1430
            :|:|.||||.|||.|||.|..|::|||:.:|::::|...:|.:.||.:| ..||    |:|||||
  Rat  1804 VTQCVEKGRVKCDHYWPADQDPLYYGDLILQMVSESVLPEWTIREFKIC-SEEQLDAHRLLRHFH 1867

  Fly  1431 FTTWPDFGVPNPPQTLVRFVRAFRDRI----GAEQRPIVVHCSAGVGRSGTFITLDRILQQINTS 1491
            :|.|||.|||...|:|::|||..||.|    ||  .|.||||||||||:|||:.|||||||:::.
  Rat  1868 YTVWPDHGVPETTQSLIQFVRTVRDYINRSPGA--GPTVVHCSAGVGRTGTFVALDRILQQLDSK 1930

  Fly  1492 DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGK------ENIVGPARE 1540
            |.|||:|.|:.:|..||.|||||.||:.:|||:..||..:      ||.:.|..|
  Rat  1931 DSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRNEQENPLFPIYE 1985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	19/92 (21%)
		fn3	220..304	CDD:278470	22/83 (27%)
		fn3	315..391	CDD:278470	21/85 (25%)
		FN3	405..494	CDD:238020	23/91 (25%)
		FN3	511..574	CDD:238020	20/80 (25%)
		FN3	583..671	CDD:238020	22/95 (23%)
		fn3	683..753	CDD:278470	17/69 (25%)
		fn3	787..850	CDD:278470	23/65 (35%)
		fn3	866..935	CDD:278470	20/73 (27%)
		fn3	961..1043	CDD:278470	17/81 (21%)
		PTPc	1272..1525	CDD:214550	150/260 (58%)
		PTPc	1298..1525	CDD:238006	135/234 (58%)
Ptprb	NP_001359063.1	fn3	113..195	CDD:365830
		FN3	204..273	CDD:214495
		fn3	292..365	CDD:365830
		fn3	394..455	CDD:365830	4/29 (14%)
		fn3	470..542	CDD:365830	19/94 (20%)
		fn3	645..723	CDD:365830	22/85 (26%)
		fn3	733..809	CDD:365830	22/89 (25%)
		fn3	822..895	CDD:365830	21/75 (28%)
		fn3	909..982	CDD:365830	20/88 (23%)
		fn3	1009..1077	CDD:365830	22/75 (29%)
		fn3	1088..1161	CDD:365830	21/81 (26%)
		fn3	1176..1249	CDD:365830	24/81 (30%)
		fn3	1263..1341	CDD:365830	22/79 (28%)
		fn3	1357..1436	CDD:365830	17/83 (20%)
		PTP_tm	1460..1648	CDD:376280	57/194 (29%)
		R-PTPc-B	1734..1961	CDD:350465	131/229 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1546
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2125
Inparanoid	1	1.050	564	1.000	Inparanoid score	I1035
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	1	1.000	-	-		otm44977
orthoMCL	1	0.900	-	-		OOG6_106915
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4185
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.870