DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Col20a1

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_038962690.1	Gene:	Col20a1 / 311716	RGDID:	1563901	Length:	1367	Species:	Rattus norvegicus

Alignment Length:	1291	Identity:	228/1291 - (17%)
Similarity:	406/1291 - (31%)	Gaps:	409/1291 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LTWTVTITTAPDPPSNLSVQVRSGKNAIIL--------WSPPTQGSYTAFKIKVLGLSEASSSYN 169
            ::|:: ::....|.||..|.|.|.....:|        |. ..:||...:.::|   :..:....
  Rat    12 VSWSL-VSLLHTPTSNPVVTVSSRLRLAVLPEDRLQMKWR-EAEGSGLGYLVQV---TPMAGDLE 71

  Fly   170 RTFQVNDNTFQHSVKELTPGATYQVQAYTIYDG----------------KESVAYTSRNFTTKPN 218
            :...:...|.:.:|..|:|..:|.:|.:.:.|.                .:|:...||.......
  Rat    72 QELVLTTKTPKATVGGLSPSKSYTLQIFELTDSGPVLLARREFVIEDLKSQSLGRGSRRLAGATL 136

  Fly   219 TPGKF-------------IVWFRNETTLLVLW-----QPPYPAGIYTHYKVSIEP-PD---ANDS 261
            .|..|             .:.|.:...|.:|.     |.....|:  ..:.|.:| ||   .:.:
  Rat   137 EPPSFPLRDPDSEKTSEPSIAFTSSRDLPILGVASKDQRKLKQGL--GVQDSAQPTPDLERQSHT 199

  Fly   262 VLYVEKEGE---------PPGPAQAAFKGLVPG------------RAYNISVQT---MSEDEISL 302
            .:.|.|.|:         ||.||...|  ||.|            :.:..|:.|   :..|::.:
  Rat   200 AVSVGKRGKLDDPQFQCTPPTPADIIF--LVDGSWSIGHNNFQQVKDFLASIITHFAIGPDKVQV 262

  Fly   303 PTTAQYRTVPLR--PLNVTFDRDFITS----------NSF------------------------R 331
            ..| ||...|..  .||....::.:.:          |:|                        :
  Rat   263 GLT-QYSGDPQTEWDLNSFHTKEQVLAAVHHLHYKGGNTFTGLALTHVLGQNLKPAAGVRPEAAK 326

  Fly   332 VLWEAPKGISEFD---------KYQVSVATTRRQSTVPR------SNEPVAF-----FDFRDIAE 376
            ||.....|.|:.|         ...:.|.|......|..      :::|:..     .||..:..
  Rat   327 VLILVTDGKSQDDVRTAARVLKDQDIDVFTVAGVKNVDEAELKLLASQPLDITVHNVLDFPQLTT 391

  Fly   377 PGKTFN-VIVKTVSGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEADPASTQD-EYRI 439
            .....: :|.:.:.|:....||.|...|.|||.....::....::::.::|  .||.... :|.|
  Rat   392 LAPLLSRLICQKIQGRGPVKPAAGTRILDPLPTPTRLTLTHVTSSSIHLSW--TPALYPPLKYLI 454

  Fly   440 VYHELE-------TFNGDTSTLTTDRTRFTLESLLPGRNYSLSV-----QAVSKKMESNETSIFV 492
            |:....       ...|..|::       .|.:|.....||:||     ..|.|.::...|:  .
  Rat   455 VWQPSRGGAPKEVVVEGPVSSM-------ELGNLTSNTEYSVSVLPVYESGVGKSLQGRATT--A 510

  Fly   493 VTRPSSPIIEDLKSIRMGLNISWKSDVNSKQ--EQYEVLYSRNGTSDLRTQKTKESRLVIKNLQP 555
            ...|..|:.....:.|. |:::|:....:.|  .|| :|.:..|....|........:|:.:|:|
  Rat   511 PLPPPGPLTLAAVTPRT-LHLTWQPSAGATQYLVQY-LLAASTGEEQKREVHVGRPEVVLDDLEP 573

  Fly   556 GAGYELKVFAVSHDLRSEP---HAYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIR 617
            |..||:.|.::.....||.   ||  :...|.|||:::...||.||..|.|.........:.|..
  Rat   574 GQDYEVSVQSLRGPEASEARNIHA--RTPVPGPPRHLSFSDVRYNSTCVSWEAQRPVRLVKVSYV 636

  Fly   618 YRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSF-GVESPVPQEVNTTVPPNPVSNIIQ 681
            ....|....:::|. ..|.|.:..::....|||:|..... |..|.:...|.|...|:|....:.
  Rat   637 SSDGSHSGQIQVPG-NVTSATLGPLSSSTVYTIRVTCFYLRGGSSVLTGHVTTQKAPSPSQLSVT 700

  Fly   682 LVDSRNITLEW-PKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQY 745
            .:....:.|.| ......|..|.:||.|           :.|.| |.::|         :||
  Rat   701 ELPGDTVKLSWLATALSGVLVYQIKWMP-----------LGEGK-AHEIS---------VPG--- 741

  Fly   746 KFDIQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDER-DTITLSYTPTPQSSSKFDIYRFS 809
                   :.|     |::.|..|..::.::.:....::..| |.::|.|||:..:.|
  Rat   742 -------TLG-----TAILPGLMKHVEYEITILAYYRDGTRSDPVSLRYTPSAANRS-------- 786

  Fly   810 LGDAEIRDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATN 874
                                                                    |.:.|..::
  Rat   787 --------------------------------------------------------PPSSLALSS 795

  Fly   875 ITDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNMT----TRNEITISDLRPHRNYTFTVVVRSG 935
            .|...:.:.|..|.|....:.:.|..|.....:...    ||:.:.:.||.....|...|....|
  Rat   796 ETPNSLQVSWAPPSGHVLHYRLNYTLASGSGPEKSISVPGTRSHVVLRDLMSAAKYRVLVSAVYG 860

  Fly   936 TESSVLRSSSPLSASFTTNEAVPGRVERFHP-TDVQPSEINFEWSLPSSEANGVIRQFSIAYTNI 999
            ...|:     .:||::.| .|.|.    .|| :.:...::...:.|.:.|           |.:|
  Rat   861 AGESM-----AVSATYRT-AACPA----LHPDSSLSGYDLMMAFGLVAKE-----------YASI 904

  Fly  1000 NNLTDAGMQDFESEEAFGVI--------------------KNLKPGETYVFKIQAKTAIGFGPE- 1043
            ..:.       ....||||.                    ..|.|..|.||.::..      ||
  Rat   905 RGVA-------MEPSAFGVAPTFTLFKDAQLMRRVSDVHPATLPPEHTIVFLVRLL------PET 956

  Fly  1044 -RE--------YRQTMPILA---------------PPRPATQVVPTEVYRSSSTIQIRFRKNYFS 1084
             ||        .....|||.               ..|.|.|.:..::..:.......|.|.:.:
  Rat   957 PREAFALWQMMAEDFQPILGVLLDAGRKSLTYFNHDSRAALQEITFDLQDAKKIFFGSFHKVHIA 1021

  Fly  1085 DQNGQVRMYTII--VAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTE 1147
            ..:.::|:|...  |||....:|.......::                            |:|
  Rat  1022 VGHSKIRLYVDCRKVAERPIGDAGSPPTAGFI----------------------------TLG-- 1056

  Fly  1148 NCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTD--------------TAYSFPI 1189
                 ::....||..|..|:::::.....:|.:.|              |..:||:
  Rat  1057 -----RLAKARGPRSSSATFQLQMLQIMCSDTWADKDRCCELPALRDGETCPAFPL 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	18/104 (17%)
		fn3	220..304	CDD:278470	25/129 (19%)
		fn3	315..391	CDD:278470	16/130 (12%)
		FN3	405..494	CDD:238020	20/101 (20%)
		FN3	511..574	CDD:238020	16/64 (25%)
		FN3	583..671	CDD:238020	23/88 (26%)
		fn3	683..753	CDD:278470	13/70 (19%)
		fn3	787..850	CDD:278470	6/62 (10%)
		fn3	866..935	CDD:278470	14/72 (19%)
		fn3	961..1043	CDD:278470	15/102 (15%)
		PTPc	1272..1525	CDD:214550
		PTPc	1298..1525	CDD:238006
Col20a1	XP_038962690.1	vWA_collagen_alphaI-XII-like	222..386	CDD:238759	25/166 (15%)
		fn3	423..501	CDD:394996	16/86 (19%)
		fn3	522..586	CDD:394996	16/65 (25%)
		fn3	603..671	CDD:394996	17/68 (25%)
		fn3	692..768	CDD:394996	19/111 (17%)
		fn3	797..865	CDD:394996	13/67 (19%)
		LamG	887..1081	CDD:419873	37/252 (15%)
		Collagen	1172..1215	CDD:396114
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000