DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptpn14

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_008768075.1	Gene:	Ptpn14 / 305064	RGDID:	1307885	Length:	1189	Species:	Rattus norvegicus

Alignment Length:	1243	Identity:	261/1243 - (20%)
Similarity:	445/1243 - (35%)	Gaps:	349/1243 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 RTRFTLESLLPGRNYSLSVQA---VSKKMESNETSIFVVTRPSSPIIED--LKSIRMGLNISWKS 517
            |.|.:||.::  |...|:|||   ...:.:|.|.....|..|....:|:  |:.:...:....|:
  Rat   130 RLRCSLEQVI--RLAGLAVQADFGDYNQFDSQEFLREYVLFPMDLAMEEAALEELTQKVAQEHKA 192

  Fly   518 DVNSKQEQYEVLYSRNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAV--SHDLRSEPHAYFQA 580
            .......:.|::|                   |..::...|:..::|.|  ||........:|..
  Rat   193 HSGILPAEAELMY-------------------INEVERLDGFGQEIFPVKDSHGNSMHLGIFFMG 238

  Fly   581 VYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADI--TDMT 643
            ::   .||    .:...:|:..|:  :.|..|.         .:..:.|..:...|..:  ||..
  Rat   239 IF---VRN----RIGRQAVIYRWN--DIGTVTH---------SKAAILLELIDKEETALFHTDDI 285

  Fly   644 KGEKYTIQVNTV--SFGVESPVPQEVNTTVPP---NPVSNIIQLVDSRNITLEWPKPE-GRVESY 702
            :..||..::.|.  .|..::.:..|.:.:.||   .|.               |.:.. .|.:.|
  Rat   286 ENAKYISRLFTTRHKFYKQNKICTEQSNSPPPIRRQPT---------------WSRSSLPRQQPY 335

  Fly   703 ILKWWPSDNPGRVQ-TKNVSENKSADDLSTVRVLIGELMPGVQ--------YKFDIQ----TTSY 754
            ||.      |..|| :::.||..::.|         .:.||.:        ...|:.    |.:.
  Rat   336 ILP------PMHVQCSEHYSETHTSQD---------SIFPGNEEALYCNSHNSLDLNYLNGTVTN 385

  Fly   755 GILSGITSL--------YPRTMPLIQ------SDVVVANGEKEDERDTITL-SYTPTPQSSSKFD 804
            |.:..:.|:        :.:..|:..      ||::.|:........||.: ||.|||...:...
  Rat   386 GSVCSVHSINSLSCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSTIIVPSYRPTPDYETVMR 450

  Fly   805 IYRFSL--GDAEIRDKEKL------ANDTDRKVTFTGLVPGRLYNITV-WTVSGGVASLPIQRQD 860
            ..:..|  .|::.|....|      |.:...::.::.......:..|| :...||.....:...|
  Rat   451 QMKRGLLHADSQSRSLRNLNIINTHAYNQPEELVYSQPEMRERHPYTVPYAPQGGYGHKLVSPSD 515

  Fly   861 RLYPE-------PITQLHATNITDTEISLRWDLPKGEYNDFDIAYLTADNLLAQNM--------T 910
            ::.|:       |.....:..::..|:: ...|...::      |.|| ::|...:        .
  Rat   516 QVNPQNSAMPSKPGAGSISHTVSTPELA-NMQLQGAQH------YSTA-HMLKNYLFRPPPPYPR 572

  Fly   911 TRNEITISDLRPHRN-YTFTVVVRSGTESSVLRSSSPLSASFTTNEAVP---------------- 958
            .|...:..||..||: |.      ||:...::.....||......::.|
  Rat   573 PRPATSTPDLASHRHKYV------SGSSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTAT 631

  Fly   959 -------GRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAF 1016
                   |.|.:.|..:|..|.:.      ..||. .::..:|.....|.|.:.|    .||||.
  Rat   632 KHHGGGGGAVNKRHSLEVMNSMVR------GMEAM-TLKSLNIPMARRNTLREQG----PSEEAG 685

  Fly  1017 GVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKN 1081
            |...:..|...:.......|.:....|.|..:..|..||..|                ::|.:..
  Rat   686 GHDVHGLPQYHHKKTFSDATMLIHSSESEEEEEAPEAAPQIP----------------ELREKVE 734

  Fly  1082 YFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTI-- 1144
            |    :.|::             |:...:||              ...|.||...:||.:.|:
  Rat   735 Y----SAQLQ-------------AALARIPS--------------RPPPEYPGPRKSVSNGTLRQ 768

  Fly  1145 --GT-------ENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIV 1200
              ||       .....|      ||.|:.:..|.:..|..||                   ||..
  Rat   769 DQGTLLPAMARARVLRH------GPAKALSVSRAEQLAVNGA-------------------SLGP 808

  Fly  1201 AITVP-LTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIKNF------- 1257
            :|:.| ||.:          |.|..  ::..|:...::..||.||:||  |.::|:|.
  Rat   809 SISEPDLTSV----------KERVK--KEPVKERPVSEMFSLEDSIIE--REMMIRNLEKQKMTG 859

  Fly  1258 --AEHYRLM------------SADSDFRFS-----------------------EEFEELKHVGRD 1285
              |:...||            |...|.|..                       .|:|::.:...:
  Rat   860 LQAQKRPLMLAALNGLSVARVSGREDGRHDVTRVPMDERLRALKKKLEDGMVFTEYEQIPNKKAN 924

  Fly  1286 QPCTFADLPCNRPKNRFTNILPYDHSRFKLQPVDDDEGSDYINANY---VPGHNSPREFIVTQGP 1347
            ...:.|.||.|..::|...::||:.:|.:|.|..:: .:.||||::   |.| .|...:|.||||
  Rat   925 GIFSTATLPENAERSRIREVVPYEENRVELIPTKEN-NTGYINASHIKVVVG-GSEWHYIATQGP 987

  Fly  1348 LHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWP---NDTVPVFYGDIKV--QILNDSH- 1406
            |..|..|||:|.||.....|.|:|...|.||.|..:|||   :......||..||  :...||.
  Rat   988 LPHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTDSGC 1052

  Fly  1407 YADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQTLVRF------VRAFRDRI--GAEQR- 1462
            ||...:....|..|.| |.:.|..:|.||..|.|...|..:.:      ||...:.:  |.:.|
  Rat  1053 YATTGLKVKHLLSGQE-RTVWHLQYTDWPHHGCPEDVQGFLSYLEEIQSVRRHTNSVLEGVKTRH 1116

  Fly  1463 -PIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA 1526
             ||||||||||||:|..|..:.::..:..::.|::..::..:|::|::|:||..||..::|.|:.
  Rat  1117 PPIVVHCSAGVGRTGVVILSELMIYCLEHNEKVEVPTMLRFLREQRMFMIQTIAQYKFVYQVLVQ 1181

  Fly  1527 VLEGKENI 1534
            .|:....|
  Rat  1182 FLQNSRLI 1189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020	11/38 (29%)
		FN3	511..574	CDD:238020	9/64 (14%)
		FN3	583..671	CDD:238020	15/91 (16%)
		fn3	683..753	CDD:278470	15/83 (18%)
		fn3	787..850	CDD:278470	14/72 (19%)
		fn3	866..935	CDD:278470	13/77 (17%)
		fn3	961..1043	CDD:278470	17/81 (21%)
		PTPc	1272..1525	CDD:214550	88/294 (30%)
		PTPc	1298..1525	CDD:238006	82/245 (33%)
Ptpn14	XP_008768075.1	B41	24..220	CDD:214604	20/110 (18%)
		PH-like	215..305	CDD:418428	19/107 (18%)
		PTPc-N14	898..1184	CDD:350447	89/288 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910