DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Tnn

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001100659.2	Gene:	Tnn / 304913	RGDID:	1306002	Length:	1562	Species:	Rattus norvegicus

Alignment Length:	1226	Identity:	263/1226 - (21%)
Similarity:	449/1226 - (36%)	Gaps:	289/1226 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 TAPD-----PPSNLSVQVRSGKNAIIL-WSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVNDNTF 179
            |.||     .|..|.: ::|.:|:::: |.|.::..:.......||..:|      |.||.....
  Rat   255 TGPDCSQVVAPQGLQL-LKSTENSLLVSWEPSSEVDHYLLSYYPLGKEQA------TKQVRVPKE 312

  Fly   180 QHS--VKELTPGATYQVQAYTIYDGKESVAYTSRNF--TTKPNTPGKFIVWFRNETTLLVLWQPP 240
            ||:  :..|.||..|.|   |:.:.|:.::.:.::.  ||.....|...|....||:|.|.|:.|
  Rat   313 QHTYDITGLLPGTKYIV---TLRNVKKDISSSPQHLLATTDLAVVGTAWVNEETETSLDVEWENP 374

  Fly   241 Y----------------------------PAGIY--------THYKVSIEP-------------- 255
            .                            |...|        |.||:::.|
  Rat   375 LTEVDYYKLRYGPLTGQEVTEVTVPKSRDPKSRYDITGLQPGTEYKITVVPIRGDLEGKPILLNG 439

  Fly   256 -------------------------PDAND----SVLYVEKEGE------PPGPAQAAFKGLVPG 285
                                     |...|    .|.|:..:||      |...:.....||.||
  Rat   440 RTEIDGPTNVVTNQVTEDTASVSWDPVRADIDKYVVRYISHDGETKEKAVPKDQSSTVLTGLKPG 504

  Fly   286 RAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQVSV 350
            .||.:.|.....::.|.....:..|....|.|:..||  :|.||..|.|:..:  :|.|:|.||.
  Rat   505 EAYKVFVWAERGNQGSKKADTKALTEIDSPENLVTDR--VTENSLSVSWDPVE--AEIDRYVVSY 565

  Fly   351 ATT---RRQSTVPRSNEPVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPATGD------VTLRPL 406
            .:.   .:|..|.:..........    .||..:.|.|         |...||      .|..|.
  Rat   566 TSVDGETKQVPVRKDQSSTVLTGL----SPGVEYKVYV---------WAEKGDRESKKANTKAPT 617

  Fly   407 PVRNLRSINDDKT--NTMIITWEADPASTQ-DEYRIVYHELETFNGDTSTLTT--DRTRFTLESL 466
            .:.:.:::..|:.  ||:.::|  ||.... |.|.:.|   .:.:|:|..:..  :::...|..|
  Rat   618 DIDSPKNLVTDQVTENTLSVSW--DPVQANIDRYMVSY---TSADGETREVPVPKEKSSTVLTGL 677

  Fly   467 LPGRNYSLSVQAVSKKMESNETSIFVVTRPSSP--IIEDLKSIRMGLNISWKSDVNSKQEQYEVL 529
            .||..|.:.|.|.....||.:.:....|....|  ::.| :.....|::|| ..|.:..::|.|.
  Rat   678 RPGMEYKVHVWAQKGTQESRKANTKAPTDIDGPKNLVTD-QVTETTLSVSW-DPVEADIDRYMVR 740

  Fly   530 Y-SRNG-TSDLRTQKTKESRLVIKNLQPGAGYELKVFAV--SHDLRSEPHAYFQAVYP---NPPR 587
            | |.:| |.::...|.|.| .|::.|:||..|::.|:|.  :.|.|.   |..:|  |   :.|:
  Rat   741 YTSPDGETKEVPVSKDKSS-TVLRGLRPGVEYKVDVWAQKGAQDSRK---ANTKA--PTDIDSPK 799

  Fly   588 NMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQV 652
            |:..|.|..::..|.|.|.|: :...|.:||.:...:....|.....|...:|.|..|.:|.:.|
  Rat   800 NLVTEQVTESTATVSWDPVEA-DIDRYVVRYTSVDGETREFLVGKDQTSTILTGMKPGVEYQVDV 863

  Fly   653 NTVSFGVESPVPQEVNTTVPPN---PVSNIIQLVDSRNITLEWPKPEGRVESYILKWWPSDNPGR 714
            .......||   ::.:|..|.:   |.:.:...|....:::.|...|..::.|::::...|.
  Rat   864 WAQKGTRES---RKTSTKAPTDIDGPKNLVTDQVTETTLSVSWDPVEADIDRYMVRYTSPDG--- 922

  Fly   715 VQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDI------QTTSYGILSGITSL-YPRTMPLIQ 772
             :||.|..:|  |..|||   :..|.|||:||.|:      |.:........|.: .|:.:.:.|
  Rat   923 -ETKEVPVSK--DKSSTV---LRGLRPGVEYKVDVWAQKGAQDSRKANTKAPTDIDSPKNLAINQ 981

  Fly   773 SDVVVANGEKEDERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGLVPG 837
            .           ...|:::|:.|......:: :.|::..|.|  .||.|.....|....|||.||
  Rat   982 V-----------TETTLSVSWDPVQADIDRY-VVRYTSADGE--SKEFLIGKEQRSTVLTGLRPG 1032

  Fly   838 RLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRWDLPKGEYNDFDIAYLTAD 902
            ..|.:.||...|...|.....:.....:....|....:|:...::.||..:.:.:.:.:.|.:||
  Rat  1033 VEYKVEVWAQKGARESKKANTKGHTDIDSPKNLVTNQVTENTATISWDPVQADIDRYMVRYTSAD 1097

  Fly   903 NLLAQNMTTRNE---ITISDLRPHRNYTFTVVVRSGT-ESSVLRSSSPLSASFTTNEAVPGRVER 963
            . ..:.:..|.|   ..::.|||...||..|..:.|. ||...::.:|.......| .|..||..
  Rat  1098 G-ETREVPVRKEKSSTVLTGLRPGVEYTVQVWAQKGARESRKAKTKAPTEIDSPKN-LVTNRVTE 1160

  Fly   964 FHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAGMQDFESEEAFGVIKNLKPGETY 1028
                    :.....|    ......|.::.:.||:.:..|..  .....:::..::..||||..|
  Rat  1161 --------NTATISW----DPVRATIDRYMVRYTSADGETKE--VPVSKDQSSTILTGLKPGMEY 1211

  Fly  1029 VFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMY 1093
            ...:.|:..     .||.::     |..:..|::.|.:.:|...
  Rat  1212 TIHVWAQKG-----ARESKK-----ADTKALTEIDPPKNFRPFG--------------------- 1245

  Fly  1094 TIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQA-IDPY---YPFENRSVEDFTI--GTENCDNH 1152
                    ..::||:           ..|:|..| ||.|   |...|..:::..:  |.:..:..
  Rat  1246 --------VTHSSGV-----------LTWMPPSAQIDGYILTYQLPNGILKEVELQRGQQRFELQ 1291

  Fly  1153 KIGYCNGPLKSGTTYRVKVRAFTG--ADKFTDTAYS-----FPIQTD----QDNTS 1197
                   .|:.|.||.|.:.||.|  ..:...|..|     ||..:|    |.||:
  Rat  1292 -------DLEQGVTYPVSLVAFKGNQRSRSVSTTLSTVDARFPHPSDCSQVQQNTN 1340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470	22/88 (25%)
		fn3	220..304	CDD:278470	29/168 (17%)
		fn3	315..391	CDD:278470	20/78 (26%)
		FN3	405..494	CDD:238020	21/93 (23%)
		FN3	511..574	CDD:238020	22/66 (33%)
		FN3	583..671	CDD:238020	22/90 (24%)
		fn3	683..753	CDD:278470	21/75 (28%)
		fn3	787..850	CDD:278470	18/62 (29%)
		fn3	866..935	CDD:278470	15/71 (21%)
		fn3	961..1043	CDD:278470	12/81 (15%)
		PTPc	1272..1525	CDD:214550
		PTPc	1298..1525	CDD:238006
Tnn	NP_001100659.2	EGF_2	<142..166	CDD:285248
		EGF_2	169..197	CDD:285248
		EB	181..233	CDD:279949
		EGF_2	233..259	CDD:285248	2/3 (67%)
		fn3	264..332	CDD:278470	20/77 (26%)
		fn3	359..434	CDD:278470	13/74 (18%)
		fn3	444..521	CDD:278470	14/76 (18%)
		FN3	532..608	CDD:214495	23/92 (25%)
		FN3	620..696	CDD:214495	18/80 (23%)
		fn3	708..785	CDD:278470	23/79 (29%)
		fn3	796..875	CDD:278470	20/82 (24%)
		fn3	884..961	CDD:278470	22/85 (26%)
		fn3	972..1049	CDD:278470	21/90 (23%)
		FN3	1060..1136	CDD:214495	16/76 (21%)
		FN3	1148..1224	CDD:214495	16/95 (17%)
		fn3	1236..1313	CDD:278470	21/123 (17%)
		FReD	1327..1540	CDD:238040	5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910