DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and Ptpn18

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_038939136.1	Gene:	Ptpn18 / 301333	RGDID:	1311586	Length:	459	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	110/453 - (24%)
Similarity:	179/453 - (39%)	Gaps:	89/453 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1253 LIKNFAEHYRLMSADSDFRFSEEFEELK--------------HVGRDQPCTFADLPCNRPKNRFT 1303
            |:::|.|.............:.||.::|              ..|..|.        |..|||:.
  Rat     7 LVRSFLEQQEARDHREGAILAREFSDIKARSVAWKTEGVCSTKAGSQQG--------NSKKNRYK 63

  Fly  1304 NILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIV 1368
            :::|||.:|..|..:.::...||||||::.|.:..:.:|.|||||..|..||||:.||...:.|:
  Rat    64 DVVPYDETRVILSLLQEEGHGDYINANFIRGTDGSQAYIATQGPLPHTLLDFWRLVWEFGVKVIL 128

  Fly  1369 MLTRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHY-ADWVMTEFMLC-----RG-SEQRIL 1426
            |..:..|.||.||::||..:..|:..|...:.:..::.. ||..:....:.     :| .|.|.:
  Rat   129 MACQETENGRRKCERYWAQEREPLQAGPFCITLTKETALTADITLRTLQVTFQKVPKGQKESRPV 193

  Fly  1427 RHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTS 1491
            ....:.:|||.|||:....::..|...|...|....|:.||||||.||:|....:|.:.|.:.|.
  Rat   194 HQLQYMSWPDHGVPSSSDHILTMVEEARCLQGLGPGPLCVHCSAGCGRTGVLCAVDYVRQLLLTQ 258

  Fly  1492 DY---VDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQ 1553
            ..   ..:|.:|..|||:|...||||:||..::..:..:.         :|.:.:|...
  Rat   259 TIPPNFSLFEVVLEMRKQRPAAVQTEEQYRFLYHTVAQLF---------SRTLQNNSPL------ 308

  Fly  1554 LDENGDVVATIEGHLSHHDLQQAEAEAIDDEN----AAILHDDQQPLTSSFTGHHTHMPPTTSM- 1613
                            :.:|::..|....|.:    ::.|....:||...........|||..|
  Rat   309 ----------------YQNLKENRAPICKDSSSLRTSSALPATSRPLGGVLRSISVPGPPTLPMA 357

  Fly  1614 ------------SSFGGGGGGHTNVDAP------DRXHSVVNQSDNNNSVVI---VLVDNKPS 1655
                        :..|.|.....:.|.|      .|....|:.::|......   |..|..||
  Rat   358 DTYAVVQKRGAPAGTGPGTRAPNSTDTPIYSQVAPRIQRPVSHTENAQGTTALGRVPADENPS 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	84/276 (30%)
		PTPc	1298..1525	CDD:238006	78/236 (33%)
Ptpn18	XP_038939136.1	PTP_DSP_cys	27..298	CDD:421693	84/278 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910