DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptprj

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_038960581.1	Gene:	Ptprj / 29645	RGDID:	3454	Length:	1354	Species:	Rattus norvegicus

Alignment Length:	1398	Identity:	370/1398 - (26%)
Similarity:	607/1398 - (43%)	Gaps:	292/1398 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 VEKEGEPPGPAQAAFKGLVPGRAYNISVQTMSEDEISLPTTAQYRTVP--------LRPL----- 316
            :|.|...||....|  |.|||        |....:...|...:.||.|        |.||
  Rat    87 LEAETRAPGFGHTA--GRVPG--------TFQGAQGMKPAARETRTPPRSPGLRWALLPLLLLLR 141

  Fly   317 ------------NVTFDRDFITSNSFRVL-WEAPKGISEFDKYQVSVATTRRQSTVPRSNEPVAF 368
                        :..||.:.:||.:..|| |:  ...|...:|:::...|.|.:...:::
  Rat   142 QGQVVCAGAVAPSPVFDVEAVTSPTSVVLTWK--HNDSATSEYKINEGNTLRYTVKNQTS----- 199

  Fly   369 FDFRDIAEPGKT--FNVIVKTV---SGKVTSWPATGDVTLRPLPVRNLRSINDDKTNTMIITWEA 428
            |:...:: |..:  |::.:.||   |||    |...::|..|.||.:|:......|.. ::.|
  Rat   200 FNITGLS-PATSYKFSITLGTVNETSGK----PTYKNITTEPWPVSDLQVAYIGVTQA-LLAW-- 256

  Fly   429 DPASTQDEYRIVYHELETFNGDTSTLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVV 493
            ..|:....||:...||           |..:...:..|.||.:.||:||.      ||||.
  Rat   257 SNANGTASYRMQIVEL-----------TTNSSGGISDLKPGTHKSLAVQG------SNETQ---- 300

  Fly   494 TRPSSPIIEDLKSIRMGLNISW-----KSDVNSKQEQYEVLYSRNGTSDLRTQKTKESR------ 547
                    .||          |     .:|.|..:.......|:...:.|.:.....:|
  Rat   301 --------HDL----------WVTEGVSADANGTEGSPVANISQLHKNSLASADPPSARDPSLTE 347

  Fly   548 LVIKNLQPGAGYELKVFAVSHD-LRSEP-HAYFQAVYPNP------------PRNMTIETVRSNS 598
            :::..|:|...|::.:::.:.| ...:| :..|:.   ||            ..|||: |.:||:
  Rat   348 VLLTELKPDTQYKVTIYSQAADGTEGQPGNKVFKT---NPIQVSDIRAVNISDSNMTL-TWKSNN 408

  Fly   599 VLVHWSPPESGEFTEYSIRYR--TDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSF-GVE 660
            ...|.|      || |.|...  :||..:     :|..|:|.|..::....|.|.|  :.| |..
  Rat   409 NESHAS------FT-YKIYVAGGSDSINE-----TVNETQAVIRGLSSSTLYNITV--LPFLGQT 459

  Fly   661 SPVPQEVNTTVPPNPVSNI-IQLVDSRNITLEWPKPEGR-VESYILKWWPSDNPGRVQTKNVSE- 722
            :.:|..:.....|.|||:. :..|..|.|.|.|...:.. .|.:|             |:..||
  Rat   460 AGIPGFLQVYTSPRPVSDFRVTNVSLREIGLAWRSNDSESFEIFI-------------TQEGSEK 511

  Fly   723 --NKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRTMPLIQ--SDVVVANGEKE 783
              |.|..|||   .::..|.||..|:|:|              :||.....:  |..||...:..
  Rat   512 RWNASTGDLS---YIVENLKPGTSYQFEI--------------FPRGPNGTEGPSQTVVGRTDCS 559

  Fly   784 DERDTITLSYTPTP-----QSSSKFDIYRFSLGDAEIRDKEK---LANDTDRKVTFTGLVPGRLY 840
            ...|...:|.:.|.     |::.....|.:.|    :.:.|.   ..|.:.:.:|..||.||.||
  Rat   560 AVTDIRVVSVSTTEIQLEWQNTDSASGYTYHL----VLESENGSIKTNSSQKWITVGGLTPGTLY 620

  Fly   841 NITVW----TVSGGVASLPIQRQDRLYPEPITQLHATNITDTEISLRW---DLPKGEYNDFDIAY 898
            |:|::    .:.|..:|  |.:..|  |..::.:. .|...|..:::|   |.....|: :.:..
  Rat   621 NVTIFPEVDQMEGNSSS--ITQYTR--PSNVSYIE-VNTNTTVAAIQWKNLDAASASYS-YSVLI 679

  Fly   899 LTADNLLAQNMTTR----NEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNEAVPG 959
            |.|.:  ..|:|:|    ..:||..|.|..:|...:..:  ..::.:.:..|....|...   |.
  Rat   680 LKAGD--GSNVTSRVRDIPSVTIPGLIPGVSYEVKIFTK--IRNTEVGNEVPGQKLFCME---PA 737

  Fly   960 RVERFHPTDVQPSE--INFEWSLPSSEANGV---IRQFSIAYTNINNLTDAGMQDFESEEAFGVI 1019
            :|:..| .:|.|.|  :..:|:.|....:|.   :|  |.|:.|:.:|.:..:.:  ..|....:
  Rat   738 QVDSLH-CEVVPKEPALVLKWACPPGMNSGFELGVR--SDAWDNMTHLENCTLDN--DTECRTEV 797

  Fly  1020 KNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSSSTIQIRFRKNYFS 1084
            ..|....:|...|...:........:...|..|..||.|......|.|  |.::::::|  :.|.
  Rat   798 TYLNFSTSYNISIATLSCGKMALPTQSTCTTGITDPPPPDGSPNITSV--SHNSVKVKF--SGFE 858

  Fly  1085 DQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQSYSVWLPYQ-----AIDPYYPFENRSVE---- 1140
            ..:|.::.|.:::...:|...|       .||..|:    |:     |.|.|..:..|..|
  Rat   859 ASHGPIKAYAVLLTTGEAGQPS-------TDVLKYT----YEDFKKGASDTYVTYLIRIEEKGQS 912

  Fly  1141 ---------DFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFT-------------GADKFTD- 1182
                     :..:|.::.   .:||.||.|:...:||..|..||             |.:.:..
  Rat   913 QGLSEALNYEIDVGNQST---TLGYYNGRLEPLGSYRACVAGFTNITYNLQNDGLINGDESYVSF 974

  Fly  1183 TAYSFPIQTDQDNTSLIVAI--TVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSV 1245
            :.||..:...||...:..|:  .:...:.:|.:...:|::::|       ||:: |:.:|.....
  Rat   975 SPYSEAVSLPQDPGVICGAVFGCIFGALAIVAVGGFIFWRKKR-------KDAK-NNEVSFSQIK 1031

  Fly  1246 IEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDH 1310
            .::::.|.::||..:::...|||:..|:||:|:||.:|...|...|::..||.|||:.|:||||.
  Rat  1032 PKKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLIGISLPKYAAEIAENRGKNRYNNVLPYDI 1096

  Fly  1311 SRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFE 1375
            ||.||. |......|||||||:||::|.::||.|||||.:|..|||||.||.|..||||||:|.|
  Rat  1097 SRVKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIVMLTKCVE 1160

  Fly  1376 KGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFML--CRGSEQRILRHFHFTTWPDFG 1438
            :||.||::|||:.... .||||.|.:.::....:|.:.:|::  .:.||...||.||||:|||.|
  Rat  1161 QGRTKCEEYWPSKQAQ-DYGDITVAMTSEVVLPEWTIRDFVVKNMQSSESHPLRQFHFTSWPDHG 1224

  Fly  1439 VPNPPQTLVRF---VRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIV 1500
            ||:....|:.|   ||.:..:|..|. ||:|||||||||:||||.:||::.||...:.||::|||
  Rat  1225 VPDTTDLLINFRYLVRDYMKQIPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIV 1288

  Fly  1501 YAMRKERVWMVQTEQQYICIHQCLLAVLEGKEN 1533
            |.:|..|..|||||.||:.::||:|.::..:::
  Rat  1289 YDLRMHRPLMVQTEDQYVFLNQCVLDIIRAQKD 1321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470	10/38 (26%)
		fn3	315..391	CDD:278470	19/98 (19%)
		FN3	405..494	CDD:238020	23/88 (26%)
		FN3	511..574	CDD:238020	10/74 (14%)
		FN3	583..671	CDD:238020	26/102 (25%)
		fn3	683..753	CDD:278470	21/73 (29%)
		fn3	787..850	CDD:278470	17/74 (23%)
		fn3	866..935	CDD:278470	15/75 (20%)
		fn3	961..1043	CDD:278470	17/86 (20%)
		PTPc	1272..1525	CDD:214550	128/257 (50%)
		PTPc	1298..1525	CDD:238006	117/231 (51%)
Ptprj	XP_038960581.1	FN3	153..234	CDD:238020	20/92 (22%)
		FN3	384..452	CDD:214495	21/80 (26%)
		FN3	472..556	CDD:238020	30/113 (27%)
		FN3	559..633	CDD:214495	17/77 (22%)
		fn3	644..721	CDD:394996	16/82 (20%)
		PTP_tm	852..1017	CDD:408631	34/180 (19%)
		R-PTPc-J	1086..1314	CDD:350463	116/230 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	285	1.000	Domainoid score	I1546
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16347at33208
OrthoFinder	1	1.000	-	-		FOG0001181
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020