Protein Alignment Ptp10D and Ptprm

DIOPT Version :10

• Sequence 1: NP_996413.2
• Gene: Ptp10D / 32115
• FlyBaseID: FBgn0004370
• Length: 1990
• Species: Drosophila melanogaster
• Sequence 2: NP_001162103.1
• Gene: Ptprm / 29616
• RGDID: 620776
• Length: 1486
• Species: Rattus norvegicus
• Alignment Length: 1303
• Identity: 298/1303 - (22%)
• Similarity: 483/1303 - (37%)
• Gaps: 370/1303 - (28%)

  Fly   603 WSPPESGEFTEYSIRYRTDSEQQWVRLPSVRSTEADITDMTKGEKYTIQVNTVSFGVESPVPQEV 667
            |.|  ||.|...:...:.:.::..:.||.::..:....|.   ..:....:..:.|:.: |..:|
  Rat    62 WMP--SGSFMLVNTSGKPEGQRAHLLLPQLKENDTHCIDF---HYFVSSKSNAAPGLLN-VYVKV 120

  Fly   668 NTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESYILKWWP------------------------ 708
            |.....||:.||     |.:.|..|.:.|..|.::    ||
  Rat   121 NNGPLGNPIWNI-----SGDPTRTWHRAELAVSTF----WPNFYQVIFEVVTSGHQGYLAIDEVK 176

  Fly   709 ------SDNPGRVQTKNVSENKSADDLSTV------RVLIGE--LMPGV---------------- 743
                  :..|..::.:||..|  |...:|.      |.:.|:  .:.|:
  Rat   177 VLGHPCTRTPHFLRIQNVEVN--AGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSR 239

  Fly   744 -----------------QYKFDIQTTSYGILSGITSLYPRTMPL----------------IQSDV 775
                             :|:..|:|.....:|....|..:..|:                ||.:.
  Rat   240 RFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNA 304

  Fly   776 VVANGE-----KEDERDTITLSYTP-TPQSSSKFDIYRFSLGDAEIRDKEKLANDTDRKVTFTGL 834
            ...||:     :|.|..|.:.|:.. .|..|:.:.|             ..|..||:.:::....
  Rat   305 NSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKI-------------GHLDPDTEYEISVLLT 356

  Fly   835 VPGRLYNITVWTVSGGVASL-PIQRQDRLYPEPI---TQLHATNITDTEISLRWDLPKGEYNDFD 895
            .||          .||..|. |..|......:|:   .:|....:...:|::||: |.|    ::
  Rat   357 RPG----------EGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWE-PFG----YN 406

  Fly   896 IAYLTADNLLAQ-------NMTTRNEI-----------TISDLRPHRNYTFTVVVRS--GTESSV 940
            :....:.||..:       ....|.|:           ||::|.|:.|.:..:::.:  |.:.|
  Rat   407 VTRCHSYNLTVRYCYQVGGQEQVREEVSWDMDNSHPQHTITNLSPYTNVSVKLILMNPEGRKES- 470

  Fly   941 LRSSSPLSASFTTNEAVPGRVERFHPTD-VQPS----EINFEWSLPSSEANGVIRQFSIAYTNIN 1000
                  ...:..|:|.:||.|    ||: :|.|    :|..:|..| ::..|||..:.|.|..::
  Rat   471 ------QELTVQTDEDLPGAV----PTESIQGSAFEEKIFLQWREP-TQTYGVITLYEITYKAVS 524

  Fly  1001 NL-------TDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRP 1058
            :.       ..:|.......|...:...|.||.||.|.|:|.||.||||....:.|..|.||..|
  Rat   525 SFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMP 589

  Fly  1059 ATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLE-----MPSWLDVQS 1118
            |.: ..|.:.::.:|:.:..:.  ...:...|.:|.|:|.|:..:......     .|..:..|:
  Rat   590 AYE-FETPLNQTDNTVTVLLKP--AQSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQN 651

  Fly  1119 YSVWLPYQAIDPYYPFEN-RSVEDFTIGTENCDNHKIGYCNGPLKSGTTYR-------------- 1168
            .|:..........:|.:: ::.:.||||.....|   ||.|.||....:||
  Rat   652 ASILNSQYYFAAEFPADSLQAAQPFTIGDNKTYN---GYWNTPLLPHKSYRIYYQAASRANGETK 713

  Fly  1169 ---------------------VKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAIT-----VPLT 1207
                                 :::....|..:.|......|:...:..|...|.|.     :.|.
  Rat   714 IDCVRVATKAAIIVTQLTTPYIRIAPAAGDGQLTGAVTPKPVPEPEKGTDHTVKIAGVIAGILLF 778

  Fly  1208 IILVLLVTLLFYKRRRNNCRKTTKDSRAND-----------------------------NMS--- 1240
            :|:.|.|.|:..||:....||.|..|...:                             |::
  Rat   779 VIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRS 843

  Fly  1241 ---------------------------LPDSVIEQNR---------------------------- 1250
                                       :|.:::::..
  Rat   844 VSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILDETHTMASDTSSLAQPHTYKKREAADVPYQTG 908

  Fly  1251 ----PILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNILPYDHS 1311
                .|.:.:..:|...|.....:.|.||:|.. ..|:..|...|....||.|||:.||:.||||
  Rat   909 QLHPAIRVADLLQHITQMKCAEGYGFKEEYESF-FEGQSAPWDSAKKDENRMKNRYGNIIAYDHS 972

  Fly  1312 RFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEK 1376
            |.:||.::.|..|||||.||:.|::.|..:|.||||:..|..|||||.|..|:.:|:|:|...|.
  Rat   973 RVRLQMLEGDNSSDYINGNYIDGYHRPNHYIATQGPMQETVYDFWRMVWYENTASIIMVTNLVEV 1037

  Fly  1377 GREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFML-CRG-SEQRILRHFHFTTWPDFGV 1439
            ||.||.:|||:||  ..|.||||.:::....|::|:..|.: .|| .|.|.:|.||||.|||.||
  Rat  1038 GRVKCCKYWPDDT--EIYKDIKVTLIDTELLAEYVIRTFAVEKRGIHEIREIRQFHFTGWPDHGV 1100

  Fly  1440 PNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMR 1504
            |.....|:.|||..:.:......|:|||||||.||:|.||.:|.:|........|||:..|..:|
  Rat  1101 PYHATGLLGFVRQVKSKSPPNAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELR 1165

  Fly  1505 KERVWMVQTEQQYICIHQCLL-AVLEGKENIVGPAREM----HDNEGYEGQ--QVQLDENGDVVA 1562
            ..||.|||||:||:.||..:| |.|.|..:|  ||.::    :|....:.|  ..|:.|....:.
  Rat  1166 SRRVNMVQTEEQYVFIHDAILEACLCGDTSI--PASQVRSLYYDMNKLDPQTNSSQIKEEFRTLN 1228

  Fly  1563 TIEGHLSHHDLQQA---------------------------EAEAIDDENAAILHDDQQPLTSSF 1600
            .:...|...|...|                           :.|:.:..|||::...:||.....
  Rat  1229 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIV 1293

  Fly  1601 TGH 1603
            |.|
  Rat  1294 TQH 1296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:394996
		fn3	220..304	CDD:394996
		FN3	278..>734	CDD:442628	29/166 (17%)
		FN3	583..671	CDD:238020	12/67 (18%)
		fn3	787..850	CDD:394996	10/63 (16%)
		fn3	866..935	CDD:394996	16/91 (18%)
		fn3	959..1043	CDD:394996	29/95 (31%)
		PTP_tm	1083..1187	CDD:465889	23/144 (16%)
		R3-PTPc	1301..1522	CDD:350396	103/222 (46%)
Ptprm	NP_001162103.1	MAM	22..182	CDD:214533	23/134 (17%)
		ig	192..274	CDD:395002	12/83 (14%)
		FN3	209..>638	CDD:442628	94/471 (20%)
		fn3	499..574	CDD:394996	23/75 (31%)
		R-PTPc-M-1	918..1190	CDD:350481	119/274 (43%)
		R-PTPc-M-2	1276..1481	CDD:350483	7/21 (33%)