DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and PTPN18

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_006712480.1	Gene:	PTPN18 / 26469	HGNCID:	9649	Length:	464	Species:	Homo sapiens

Alignment Length:	407	Identity:	116/407 - (28%)
Similarity:	177/407 - (43%)	Gaps:	84/407 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1265 SADSDFRFSEEFEELKHVGRD-----------QPCTF---ADLPC-----NRP----KNRFTNIL 1306
            |.||...|.|..|  ...||:           |.|:.   ||..|     :||    |||:.::|
Human     4 SLDSARSFLERLE--ARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRYKDVL 66

  Fly  1307 PYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLT 1371
            |||.:|..|..:.::..|||||.|::.|.:....:|.|||||..|..||||:.||...:.|:|..
Human    67 PYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMAC 131

  Fly  1372 RCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFML-----CRGSEQRILRHFHF 1431
            |..|.||::|::||..:..|:..|...:.::.:.    |:..:.||     ....|.|.:....:
Human   132 REIENGRKRCERYWAQEQEPLQTGLFCITLIKEK----WLNEDIMLRTLKVTFQKESRSVYQLQY 192

  Fly  1432 TTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTS----D 1492
            .:|||.|||:.|..::..|...|...|:...|:.||||||.||:|...|:|.:.|.:.|.    |
Human   193 MSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPD 257

  Fly  1493 YVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKENIVGPAREMHDNEGYEGQQVQLDEN 1557
            : .:|.:|..|||:|...||||:||..::..:..:.
Human   258 F-SLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMF----------------------------- 292

  Fly  1558 GDVVATIEGHLSHHDLQQAEAEAIDDENAAILHDDQQPLTSSFTGHHTHMPPTTSMSSFG-GGGG 1621
               .:|::....|:  |..:      ||.|.|:||...|.:.........||...:.|.. .|..
Human   293 ---CSTLQNASPHY--QNIK------ENCAPLYDDALFLRTPQALLAIPRPPGGVLRSISVPGSP 346

  Fly  1622 GHTNVDAPDRXHSVVNQ 1638
            ||...|     ::||.:
Human   347 GHAMAD----TYAVVQK 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	94/284 (33%)
		PTPc	1298..1525	CDD:238006	83/239 (35%)
PTPN18	XP_006712480.1	Y_phosphatase	56..290	CDD:278528	82/238 (34%)
PTPN18	XP_006712480.1	PTPc	59..290	CDD:238006	82/235 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910