DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and PTPN20

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_001035816.1	Gene:	PTPN20 / 26095	HGNCID:	23423	Length:	420	Species:	Homo sapiens

Alignment Length:	301	Identity:	109/301 - (36%)
Similarity:	155/301 - (51%)	Gaps:	33/301 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1246 IEQNRPILIKNFAEHYR-------LMSADSDFRFSEEFE--ELKHVGRDQPCTF--ADLPCNRPK 1299
            :.|.|| ||.||.|...       |....:.:...:||.  |||::    |..|  .:.|.||.|
Human   127 LAQIRP-LIFNFHEQTAIKDCLKILEEKTAAYDIMQEFMALELKNL----PGEFNSGNQPSNREK 186

  Fly  1300 NRFTNILPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPRE--FIVTQGPLHSTRDDFWRMCWES 1362
            ||:.:|||||.:|..|     .:..|||||:|:...|...|  :|.|||||.||.||||:|..|:
Human   187 NRYRDILPYDSTRVPL-----GKSKDYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLEN 246

  Fly  1363 NSRAIVMLTRCFEKGREKCDQYWP-NDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGS--EQR 1424
            ||..|.|:||..|.|..||..||| :...|:.....:|.:.|......:::..|.:...|  ...
Human   247 NSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSH 311

  Fly  1425 ILRHFHFTTWPDFGVPNPPQTLVRFVR-AFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQI 1488
            .::...||.|||.|.|....:.::::| |.:..:..   |:|||||||:||:|.|:.:|.:...|
Human   312 SVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG---PMVVHCSAGIGRTGVFLCVDVVFCAI 373

  Fly  1489 NTSDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLE 1529
            ..:...:|..||..||::|..||||::||   |.|...|||
Human   374 VKNCSFNIMDIVAQMREQRSGMVQTKEQY---HFCYDIVLE 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	97/262 (37%)
		PTPc	1298..1525	CDD:238006	87/232 (38%)
PTPN20	NP_001035816.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..108
		PTPc	159..411	CDD:214550	98/266 (37%)
		PTPc	185..411	CDD:238006	88/236 (37%)
		Substrate binding. /evidence=ECO:0000250	353..359		4/5 (80%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910