DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptp10D and Fn1

DIOPT Version :9

Sequence 1:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster
Sequence 2:NP_062016.2 Gene:Fn1 / 25661 RGDID:2624 Length:2477 Species:Rattus norvegicus


Alignment Length:1913 Identity:384/1913 - (20%)
Similarity:639/1913 - (33%) Gaps:526/1913 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 DDGASYRLDYSPPFGYPEPN-----TTIASREIGDEIQFSRALPGTKYNFWLYYTNFTHHDWLTW 115
            |..:.:|::|.......||.     :|..|..|.|      .|||.||...:|..:......|..
  Rat   744 DTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPD------LLPGRKYIVNVYQISEEGKQSLIL 802

  Fly   116 TVTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSYTAFKIKVLGLSEASSS-YNRTFQVNDNTF 179
            :.:.|||||.|.:.:|......:.::.||.| |...|.::|......|.||: .|.....|..| 
  Rat   803 STSQTTAPDAPPDPTVDQVDDTSIVVRWSRP-QAPITGYRIVYSPSVEGSSTELNLPETANSVT- 865

  Fly   180 QHSVKELTPGATYQVQAYTIYDGKESVAYTSRNFTTKPNTPGKFIVWFRNETT------------ 232
               :.:|.||..|.:..|.:.:.:||             ||    |:.:.|||            
  Rat   866 ---LSDLQPGVQYNITIYAVEENQES-------------TP----VFIQQETTGVPRSDDVPAPK 910

  Fly   233 -----------LLVLWQPPYPAGIYTHYKVSIEP---PDANDSVLYVEKEGEPPGPAQAAFKGLV 283
                       :.::|.||..|  .|.|:|.:.|   |..:...|.|.:.      ..|...||.
  Rat   911 DLQFVEVTDVKVTIMWTPPNSA--VTGYRVDVLPVNLPGEHGQRLPVNRN------TFAEVTGLS 967

  Fly   284 PGRAYNISVQTMSEDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISEFDKYQV 348
            ||..|...|..:.:...|.|.|||..|....|.|:.|..:  |..:..|.|..|:  :....|::
  Rat   968 PGVTYLFKVFAVHQGRESKPLTAQQTTKLDAPTNLQFVNE--TDRTVLVTWTPPR--ARIAGYRL 1028

  Fly   349 SVATTRRQSTVPRSNEPVAF-FDFRDIAEPGKTFNVIVKTVSGKVTSWPATG-DVTLRPLPVRNL 411
            :|..||.......:..|:|. :..|:: :||..:.|.:..|.|...|..||| ..||:||  |::
  Rat  1029 TVGLTRGGQPKQYNVGPMASKYPLRNL-QPGSEYTVTLMAVKGNQQSPKATGVFTTLQPL--RSI 1090

  Fly   412 RSINDDKT-NTMIITWEADPASTQDEYRIVYH-ELETFNGDTS--TLTTDRTRFTLESLLPGRNY 472
            ...|.:.| .|::|||...|       ||.:. .:....|..:  .:|:|.....:..|.||..|
  Rat  1091 PPYNTEVTETTIVITWTPAP-------RIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEY 1148

  Fly   473 SLSVQAVSKKMESNETSIFVVTRPSSPIIEDLKSIRMGLN-------ISWKSDVNSKQEQYEVLY 530
            :.::|.:....|.:...:..|..|.||    ..::.:..|       :||:.........|.:..
  Rat  1149 TYTIQVLRDGQERDAPIVNRVVTPLSP----PTNLHLEANPDTGVLTVSWERSTTPDITGYRITT 1209

  Fly   531 S----RNGTSDLRTQKTKESRLVIKNLQPGAGYELKVFAVSHDLRSEPHAYFQAVYPNPPR--NM 589
            :    :.||:........:|....:||.||..|.:.|:.|..|..|.|.:  ..|.|..|:  ::
  Rat  1210 TPTNGQQGTALEEVVHADQSSCTFENLNPGLEYNVSVYTVKDDKESAPIS--DTVIPEVPQLTDL 1272

  Fly   590 TIETVRSNSVLVHWSPPESG--------------------EFTEYSIRYRTDSEQQWVRLPSVRS 634
            :...:..:|:.:.|:|..|.                    :|.:.|:.|.|              
  Rat  1273 SFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYT-------------- 1323

  Fly   635 TEADITDMTKGEKYTIQVNTVSFGVES-PVPQEVNTTVPPNPVSNIIQLVDSRNITLEW-PKPEG 697
                :|.:..|..|.|.|.|:..|.|| |......|.||| |.......:....:.:.| |.|..
  Rat  1324 ----VTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPP-PTDLRFTNIGPDTMRVTWAPPPSI 1383

  Fly   698 RVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITS 762
            .:.:.::::.|..|...|...::|.:.:|       |::..|:||.:|           |..::|
  Rat  1384 ELTNLLVRYSPVKNEEDVAELSISPSDNA-------VVLTNLLPGTEY-----------LVSVSS 1430

  Fly   763 LYPRTMPLIQSDVVVANGEKE---------DERDTITLSYT---PTPQSSSKFDIYRFSLGDAEI 815
            :|.      |.:.:...|.::         |..|....|:|   ..|::.....|.|.....:..
  Rat  1431 VYE------QHESIPLRGRQKTGLDSPTGFDSSDVTANSFTVHWVAPRAPITGYIIRHHAEHSAG 1489

  Fly   816 RDKEKLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQLHATNITDTEI 880
            |.::.....:...:|.|.|.||..|.:|:..|:|...|.|:..|.....:....|.....|.|.:
  Rat  1490 RPRQDRVPPSRNSITLTNLNPGTEYIVTIIAVNGREESPPLIGQQSTVSDVPRDLEVIASTPTSL 1554

  Fly   881 SLRWDLPKGEYNDFDIAY-LTADNLLAQNMT---TRNEITISDLRPHRNYTFTVVVRSGTESSVL 941
            .:.|:.|......:.|.| .|..|...|..|   :::..||::::|..:||.|:...:|...|. 
  Rat  1555 LISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSP- 1618

  Fly   942 RSSSPLSASFTTNEAVPGRVERFHPTDVQPSEINFEWSLPSSEANGVIRQFSIAYTNINNLTDAG 1006
            .||.|:|.::.|....|.:::   .||||.:.|:..| |||:..   :..:.:.....|.|....
  Rat  1619 ASSKPVSINYQTEIDKPSQMQ---VTDVQDNSISVRW-LPSTSP---VTGYRVTTAPKNGLGPTK 1676

  Fly  1007 MQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYRSS 1071
            .|....::....|:.|:|...||..:.|:...|               ..:|..|...|.:.|..
  Rat  1677 SQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNG---------------ESQPLVQTAVTNIDRPK 1726

  Fly  1072 ---------STIQI----------RFRKNYFSDQNGQVRMYTIIVAEDDAKNASGL--------- 1108
                     .:|:|          |:|..|.|.::|...::.....::|.....||         
  Rat  1727 GLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGDEDTAELHGLRPGSEYTVS 1791

  Fly  1109 --------EMPSWLDVQSYSVWLPYQAIDPYYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGT 1165
                    |....:.|||.::..|..       .:...|...|:..:         ...|....|
  Rat  1792 VVALHGGMESQPLIGVQSTAIPAPTN-------LKFTQVSPTTLTAQ---------WTAPSVKLT 1840

  Fly  1166 TYRVKV--RAFTGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTIILVLLVTLLFYKRRRNNCRK 1228
            .|||:|  :..||..|        .|....|:||:||:..:..|...|.:..|           |
  Rat  1841 GYRVRVTPKEKTGPMK--------EINLSPDSTSVIVSGLMVATKYEVSVYAL-----------K 1886

  Fly  1229 TTKDSR-------ANDNMSLP-----------------------------DSVIEQNR-PI--LI 1254
            .|..||       ..:|:|.|                             |::....: |:  .|
  Rat  1887 DTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAIPANGQTPVQRTI 1951

  Fly  1255 KNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTF-ADLPCNRPKN-RFTNILP------YDHS 1311
            ......|.:........:......|....|..|... |....:.|.| ||....|      :...
  Rat  1952 SPDVRSYTITGLQPGTDYKIHLYTLNDNARSSPVVIDASTAIDAPSNLRFLTTTPNSLLVSWQAP 2016

  Fly  1312 RFKLQPVDDDEGSDYINANYVPGHNSPREFI------VTQGPL----HSTRDDFWRMCWESNSRA 1366
            |.::        :.||.....|| :.|||.:      ||:..:    ..|....:.:..::|.::
  Rat  2017 RARI--------TGYIIKYEKPG-SPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKS 2072

  Fly  1367 IVMLTRCFEKGREKCD-------------------------QYWPNDTVPVFYGDIKVQILNDSH 1406
            ..::      ||:|.|                         |..|..|.|.:..:..:|:...||
  Rat  2073 EPLI------GRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTNPGYDTENGIQLPGTSH 2131

  Fly  1407 YADWVMTEFMLCRGSEQRILRH-FHFTTWPDFGVP------------------------------ 1440
            ....|        |.:.....| |..||.|....|                              
  Rat  2132 QQPSV--------GQQMIFEEHGFRRTTPPTAATPVRLRPRPYLPNVDEEVQIGHVPRGDVDYHL 2188

  Fly  1441 -------NP---------PQTLVRFVRAFRDR---------IGAEQRPIVVHCSAGVGRSGTF-- 1478
                   ||         .||.:.:. .|::.         :|.::.|:.... .|...|.|.  
  Rat  2189 YPHVPGLNPNASTGQEALSQTTISWT-PFQESSEYIISCQPVGTDEEPLQFQV-PGTSTSATLTG 2251

  Fly  1479 ----ITLDRILQQINT-------SDYVDIFGIV--------------------YAMRKERVWMVQ 1512
                :|.:.|::.::.       .:.|.:...|                    ||:.:|  |...
  Rat  2252 LTRGVTYNIIVEALHNQRRHKVREEVVTVGNTVNEGLNQPTDDSCFDPYTVSHYAVGEE--WERL 2314

  Fly  1513 TEQQYICIHQCLLAVLEGKENIVG---------PAREMHDNEGYEGQQVQLDENGDVVATIEGHL 1568
            ::..:....|||           |         .::..|||    |...::.|..|........:
  Rat  2315 SDSGFKLTCQCL-----------GFGSGHFRCDSSKWCHDN----GVNYKIGEKWDRQGENGQRM 2364

  Fly  1569 SHHDLQQAEAEAIDDENAAILHDDQQPLTSSFTGHHTHMPPTTSMSSFGG--------------- 1618
            |...|...:.|...|.:.|..:||.:...........::....|.:.|||               
  Rat  2365 SCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGAA 2429

  Fly  1619 -----GGGGHTNVDAPDRXHSVVNQSDN 1641
                 |..|||......| |...|.:.|
  Rat  2430 EPSPDGTTGHTYNQYTQRYHQRTNTNVN 2457

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 20/81 (25%)
fn3 220..304 CDD:278470 24/109 (22%)
fn3 315..391 CDD:278470 18/76 (24%)
FN3 405..494 CDD:238020 21/92 (23%)
FN3 511..574 CDD:238020 16/73 (22%)
FN3 583..671 CDD:238020 21/110 (19%)
fn3 683..753 CDD:278470 13/70 (19%)
fn3 787..850 CDD:278470 15/65 (23%)
fn3 866..935 CDD:278470 17/72 (24%)
fn3 961..1043 CDD:278470 19/81 (23%)
PTPc 1272..1525 CDD:214550 60/384 (16%)
PTPc 1298..1525 CDD:238006 56/357 (16%)
Fn1NP_062016.2 Fibrin-and heparin-binding 1 53..273
FN1 53..90 CDD:238018
fn1 98..136 CDD:278468
FN1 142..185 CDD:214494
FN1 187..231 CDD:214494
fn1 232..271 CDD:278468
Collagen-binding 308..608
FN1 308..347 CDD:214494
FN2 353..401 CDD:128373
FN2 413..461 CDD:128373
fn1 470..508 CDD:278468
FN1 518..560 CDD:214494
fn1 561..599 CDD:278468
fn3 611..688 CDD:278470
fn3 726..796 CDD:278470 15/57 (26%)
fn3 811..882 CDD:278470 20/75 (27%)
fn3 907..987 CDD:278470 19/87 (22%)
fn3 997..1075 CDD:278470 19/82 (23%)
fn3 1095..1153 CDD:278470 15/64 (23%)
fn3 1174..1257 CDD:278470 18/86 (21%)
fn3 1267..1349 CDD:278470 18/99 (18%)
Cell-attachment 1357..1630 65/298 (22%)
fn3 1358..1439 CDD:278470 20/105 (19%)
fn3 1449..1529 CDD:278470 18/79 (23%)
fn3 1539..1620 CDD:278470 19/81 (23%)
Cell attachment site 1614..1616 0/1 (0%)
fn3 1633..1713 CDD:278470 20/101 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1661..1685 3/23 (13%)
FN3 1723..1810 CDD:238020 14/86 (16%)
Heparin-binding 2 1811..2081 55/319 (17%)
fn3 1813..1893 CDD:278470 24/114 (21%)
fn3 1905..1984 CDD:278470 8/78 (10%)
FN3 1994..2074 CDD:238020 17/88 (19%)
V region (type III connecting segment, IIICS) 2082..2201 18/126 (14%)
Cell attachment site 2181..2183 0/1 (0%)
fn3 2210..2268 CDD:278470 8/59 (14%)
Fibrin-binding 2 2296..2427 25/147 (17%)
FN1 2296..2340 CDD:214494 8/56 (14%)
FN1 2341..2382 CDD:214494 10/44 (23%)
FN1 2384..2423 CDD:238018 6/38 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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