DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and pyp2

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_594899.1	Gene:	pyp2 / 2542200	PomBaseID:	SPAC19D5.01	Length:	711	Species:	Schizosaccharomyces pombe

Alignment Length:	775	Identity:	176/775 - (22%)
Similarity:	284/775 - (36%)	Gaps:	234/775 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   886 LPKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVV---VRSGTESSVLRSSSPL 947
            |.|.|:|         ..|.:....|.:...|.|||.|..|..:.:   :.....:::||
pombe     5 LSKDEFN---------STLKSFEEQTESVSWIIDLRLHSKYAVSHIKNAINVSLPTALLR----- 55

  Fly   948 SASFTTNEAVPGRVERFHPTDVQPS--EINFEWSLPSSEANGVIRQFSI-------AYTNINNLT 1003
            ..||..     |:|......:|:.|  |||..:...||.| |:.|.:.:       .|:....|.
pombe    56 RPSFDI-----GKVFACIKCNVKVSLDEINAIFLYDSSMA-GMNRIYDLVQKFRRGGYSKKIYLL 114

  Fly  1004 DAGMQDFESEEAFGVIKNLKPGETYVFKIQ---------------AKTAIGFGPEREYRQTMPIL 1053
            ..|.:.|.|.....::......|:..:||.               :..:....|:..:...:||.
pombe   115 SNGFEAFASSHPDAIVSTEMVKESVPYKIDINENCKLDILHLSDPSAVSTPISPDYSFPLRVPIN 179

  Fly  1054 APPRPATQVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGLEMPSWLDVQS 1118
            .||...|..|.::.:                                 ::.||..|.|.:..:..
pombe   180 IPPPLCTPSVVSDTF---------------------------------SEFASHAEYPGFSGLTP 211

  Fly  1119 YSVWLP----------------------YQAIDPYYPFENR--------SVED-----FTIGTEN 1148
            :|:..|                      :||..||:|....        |..|     |.:|
pombe   212 FSIHSPTASSVRSCQSIYGSPLSPPNSAFQAEMPYFPISPAISCASSCPSTPDEQKNFFIVG--- 273

  Fly  1149 CDNHKIGYCNGP--------LKSGTTY----------RVKVRAFTGADKFTDTAYSFPIQTDQDN 1195
                     |.|        |:|..:|          ..:||:|:...|.::..          |
pombe   274 ---------NAPQQTPARPSLRSVPSYPSSNNQRRPSASRVRSFSNYVKSSNVV----------N 319

  Fly  1196 TSLIVAITVPLTIILVLLVTLLFYKRRRN--NCRKTTKDSRANDNMSL--------PDSVIEQNR 1250
            .||..|        .:.::.....||..|  |...:|..|:...::.|        |..:...|:
pombe   320 PSLSQA--------SLEIIPRKSMKRDSNAQNDGTSTMTSKLKPSVGLSNTRDAPKPGGLRRANK 376

  Fly  1251 PILIKN-----FAEHYR-----------------------LMSADSDFRFS--EEFEELKHVG-R 1284
            |...|.     |::..:                       |.:|...::|.  ||.|..:.:. .
pombe   377 PCFNKETKGSIFSKENKGPFTCNPWGAKKVSPPPCEVLADLNTASIFYKFKRLEEMEMTRSLAFN 441

  Fly  1285 DQPCTFADLPCNRP-----KNRFTNILPYDHSRFKLQPVDDDEG-SDYINANYVPGHNSPREFIV 1343
            |....:..|..:|.     |||:|:|:|||.:|.:|..   .:| ||||||:::...|  :::|.
pombe   442 DSKSDWCCLASSRSTSISRKNRYTDIVPYDKTRVRLAV---PKGCSDYINASHIDVGN--KKYIA 501

  Fly  1344 TQGPLHSTRDDFWRMCWESN--SRAIVMLTRCFEKGREKCDQYWPN--DTVPVFYGDIKVQILND 1404
            .|.|...|..|||.|.|.::  :..|||||..:|.|.|||.||||:  |......|.:::.:...
pombe   502 CQAPKPGTLLDFWEMVWHNSGTNGVIVMLTNLYEAGSEKCSQYWPDNKDHALCLEGGLRISVQKY 566

  Fly  1405 SHYADWVMTE--FMLCR-GSEQRILRHFHFTTWPDFGVPNPPQTLVRFVRAFRDRIGAEQRPIVV 1466
            ..:.|..:..  |.|.: ....:.:.||...||.|...|: .:::...:|.. |:: ....|:.|
pombe   567 ETFEDLKVNTHLFRLDKPNGPPKYIHHFWVHTWFDKTHPD-IESITGIIRCI-DKV-PNDGPMFV 628

  Fly  1467 HCSAGVGRSGTFITLDRILQ--------QINTSDYVD-IFGIVYAMRKERVWMVQTEQQY 1517
            ||||||||:||||.:|:|||        ..|..|..| ||..|.::|.:|:.|||..:|:
pombe   629 HCSAGVGRTGTFIAVDQILQVPKNILPKTTNLEDSKDFIFNCVNSLRSQRMKMVQNFEQF 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470	12/51 (24%)
		fn3	961..1043	CDD:278470	19/105 (18%)
		PTPc	1272..1525	CDD:214550	91/271 (34%)
		PTPc	1298..1525	CDD:238006	84/242 (35%)
pyp2	NP_594899.1	DSP_MapKP	4..129	CDD:238723	33/143 (23%)
		COG5599	405..709	CDD:227886	93/292 (32%)
		PTPc	461..697	CDD:238006	84/236 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940