DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and pyp3

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_594934.1	Gene:	pyp3 / 2541443	PomBaseID:	SPAC11E3.09	Length:	303	Species:	Schizosaccharomyces pombe

Alignment Length:	258	Identity:	95/258 - (36%)
Similarity:	145/258 - (56%)	Gaps:	36/258 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1299 KNRFTNILPYDHSRFKLQPVDDDEGSDYINANYV--PGHNSPREFIVTQGPLHSTRDDFWRMCWE 1361
            :||::||:||:::|.:|.|: ..|..|||||:.|  |   |.:.||.||||..::.|.||:|.|:
pombe    52 RNRYSNIVPYENTRVRLDPM-WKEACDYINASIVKIP---SGKTFIATQGPTSNSIDVFWKMVWQ 112

  Fly  1362 S--NSRAIVMLTRCFEKGREKCDQYWPNDTVPVF----YGDIKVQI--------LNDSHYADWVM 1412
            |  .|..|||||:..|:.|.|||.|||   |.:|    .||:.|.:        ||:..     :
pombe   113 SVPKSGIIVMLTKLRERHRLKCDIYWP---VELFETLNIGDLSVILVKVYTLTSLNEVQ-----V 169

  Fly  1413 TEFMLCRGSEQRILRHFHFTTWPDFGVPNPPQ--TLVRFVRAFRDRIGAEQRPIVVHCSAGVGRS 1475
            .||.|.:...::.:.||::..|||||.|:...  :|.|::::.......|..||:||||||.||:
pombe   170 REFELNKDGVKKKILHFYYNGWPDFGAPHTFSLLSLTRYIKSLSYSPDFETAPIIVHCSAGCGRT 234

  Fly  1476 GTFITLDRILQQINTS------DYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLAVLEGKE 1532
            |||:.|..||.|.:.|      :..:|..||.::|.:|:..||:..|.:.::.....:|:|||
pombe   235 GTFMALFEILSQTDDSTSTSKFEVDNIANIVSSLRSQRMQSVQSVDQLVFLYTVSQELLQGKE 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	91/249 (37%)
		PTPc	1298..1525	CDD:238006	91/249 (37%)
pyp3	NP_594934.1	COG5599	1..303	CDD:227886	95/258 (37%)
		AbiGii_2	<18..69	CDD:293478	7/16 (44%)
		PTPc	52..291	CDD:238006	91/250 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	156	1.000	Domainoid score	I1041
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47137
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3031
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840