DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp10D and FNDC5

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	NP_715637.2	Gene:	FNDC5 / 252995	HGNCID:	20240	Length:	212	Species:	Homo sapiens

Alignment Length:	229	Identity:	46/229 - (20%)
Similarity:	88/229 - (38%)	Gaps:	60/229 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   576 AYFQAVYPNPPRNMTIETVRSNSVLVHWSPPESGEFTEYSIRYRTDSEQQWVR----LPSVRST- 635
            |..||..|:.|.|:|:..:::||.:|.|...|.    |..|.:....:::.||    :..|.:|
Human    27 ALVQADSPSAPVNVTVRHLKANSAVVSWDVLED----EVVIGFAISQQKKDVRMLRFIQEVNTTT 87

  Fly   636 -EADITDMTKGEKYTIQVNTVSFGVESPVPQEVNTTVPPNPVSNIIQLVDSRNITLEWPKPEGRV 699
             ...:.|:.:..:|.:.|..:|...:||.                     |..:..:.|:...::
Human    88 RSCALWDLEEDTEYIVHVQAISIQGQSPA---------------------SEPVLFKTPREAEKM 131

  Fly   700 ESYILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLY 764
                    .|.|...|..|.:..|:        ::..||::..|...|        :.:|:.:|:
Human   132 --------ASKNKDEVTMKEMGRNQ--------QLRTGEVLIIVVVLF--------MWAGVIALF 172

  Fly   765 PRTMPLIQSDVVVANGEKEDERDTITLSYTPTPQ 798
            .|     |.|::..|....::..|.:.|.|.||:
Human   173 CR-----QYDIIKDNEPNNNKEKTKSASETSTPE 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020	21/93 (23%)
		fn3	683..753	CDD:278470	11/69 (16%)
		fn3	787..850	CDD:278470	5/12 (42%)
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550
		PTPc	1298..1525	CDD:238006
FNDC5	NP_715637.2	FN3	34..124	CDD:238020	22/114 (19%)
FNDC5	NP_715637.2	DUF4808	151..>203	CDD:318317	15/64 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910