DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp10D and Ptpra

DIOPT Version :9

Sequence 1:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster
Sequence 2:	XP_006235068.1	Gene:	Ptpra / 25167	RGDID:	3450	Length:	805	Species:	Rattus norvegicus

Alignment Length:	748	Identity:	198/748 - (26%)
Similarity:	315/748 - (42%)	Gaps:	195/748 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1090 VRMYTIIVAEDDAKNASGLEMPSWLDVQSYSV---WLPYQAIDP-YYPFENRSVEDFTIGTENCD 1150
            ::..|...|:::.|.::     |...|.|.||   :.|...::| |....|.|..|  .||:...
  Rat    35 IKTSTTESAKEENKTSN-----STSSVISLSVTPTFSPNLTLEPTYVTTVNSSHSD--NGTKRAA 92

  Fly  1151 NHKIGYCNGPLKSGTTYRVKVRAFTGA----DKFTD---------------TAYSFP-----IQT 1191
            :.:.|        |||  :......|.    ::|||               |..:||     ...
  Rat    93 STESG--------GTT--ISPNGTYGTWLTDNQFTDARTEPWEGNSSTAATTPETFPPAGNSDSK 147

  Fly  1192 DQDNTSLIVAITVPLT--IILVLLVTLLF------YKR--------RRNNCRKTTKDSRANDNMS 1240
            |:.:.:.|:|:.|.|:  :::|.::.:|:      ||:        |.:|.|....:.::...::
  Rat   148 DRRDETPIIAVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLA 212

  Fly  1241 LPDSVIEQNRPILIKNFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFADLPCNRPKNRFTNI 1305
            ...|...:..|:.:....|......||.:..|.|||..|........|..|....|:.|||:.||
  Rat   213 RSPSTNRKFPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNI 277

  Fly  1306 LPYDHSRFKLQPVDDDEGSDYINANYVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVML 1370
            |||||||..|.||:....||||||:::.|:....:||..|||...|.:|||||.||.|:..|||:
  Rat   278 LPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMV 342

  Fly  1371 TRCFEKGREKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSE------QRILRHF 1429
            |...|:...||.|||| |.....||:::|.:.:.:...|:.:.:|.:.:..:      ||::..|
  Rat   343 TNLKERKECKCAQYWP-DQGCWTYGNVRVSVEDVTVLVDYTVRKFCIQQVGDVTNRKPQRLITQF 406

  Fly  1430 HFTTWPDFGVPNPPQTLVRFVRAFR----DRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINT 1490
            |||:|||||||..|..:::|::..:    ...||    |||||||||||:|||:.:|.:|..:::
  Rat   407 HFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA----IVVHCSAGVGRTGTFVVIDAMLDMMHS 467

  Fly  1491 SDYVDIFGIVYAMRKERVWMVQTEQQYICIHQCLLA-VLEGKENIVGPAREMH-----------D 1543
            ...||::|.|..:|.:|..||||:.||:.|:|.||. .|.|...:...:.:.|           .
  Rat   468 ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLDTHLQKIYNKIPGTS 532

  Fly  1544 NEGYEGQ-------QVQLDE--NGDVVATIEGHLSHHDLQ-------------QAEAEAIDDENA 1586
            |.|.|.:       ::|.|:  .|::.|.::   .:..||             :...|..|..||
  Rat   533 NNGLEEEFKKLTSIKIQNDKMRTGNLPANMK---KNRVLQIIPYEFNRVIIPVKRGEENTDYVNA 594

  Fly  1587 AILHD---------DQQPLTSSFTGHHT-------------------------------HMPPTT 1611
            :.:..         .|.||.      ||                               ...|:.
  Rat   595 SFIDGYRQKDSYIASQGPLL------HTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD 653

  Fly  1612 SMSSFGGGGGGHTNVDAPDRXHSVVNQSDNNNSVVIVLV-----DNK------------PSSMIC 1659
            .:.|:|            |....:..:.:..:..|..|:     :||            |...|.
  Rat   654 GLVSYG------------DITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIP 706

  Fly  1660 KDSKGGNIDVLESQQQQQQQQQQQPNQGGHNIT 1692
            .|.| |.|:::.:.|:||||      .|.|.||
  Rat   707 SDGK-GMINIIAAVQKQQQQ------SGNHPIT 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020
		fn3	683..753	CDD:278470
		fn3	787..850	CDD:278470
		fn3	866..935	CDD:278470
		fn3	961..1043	CDD:278470
		PTPc	1272..1525	CDD:214550	108/262 (41%)
		PTPc	1298..1525	CDD:238006	100/236 (42%)
Ptpra	XP_006235068.1	PHA03255	<18..177	CDD:165513	34/158 (22%)
		R-PTPc-A-1	217..512	CDD:350469	116/299 (39%)
		R-PTPc-A-2	566..793	CDD:350471	34/192 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910